I tried it last night with latest Mint (18.1), TW5 and node.js, per instructions at
tiddlywiki.com but it didn't work. It was late and I was tired so I just used timeshift to revert my system to the status quo ante (I'd also just spent some time trying to get a Synology community app working and failed -- then read that things were broken by the last OS upgrade -- so was in plug-pulling mood). Sometimes you want things to just work out of the box; TW always has so far I can remember.