Hi,
I think the main advantage is, that you can easily build and test the latest version of TW on your local PC.
It lets you serve binary files eg: images or PDFs from a /files directory, so you don't need to include them in your wiki.
With the new SSE plugin mentioned in the other post it will allow a basic multi user setup on the local network.
It can be used to build different editions, that are shipped with TW eg: empty.html, or the German version which is interesting for me ;)
It can be used to run tw5.com-server to improve the TW documentation and create pull-requests to improve the docs at
tiddlywiki.com
So for me it's mainly a development environment and a playground for my own wikis.
-mario