Mark,
When it comes to serving it via http the main questions you need to ask is do you need to simply publish it as read only on the internet or do you have contributors, is its visibility or edit available online?, or do you want it hidden for you or a small number of people?. The simplest method is to edit it locally and copy up as needed or use tiddlyspot etc... Other questions are do you need search engines to recognise it etc...
What hosting service do you have available etc...
Personally I am moving to using tw-receiver, single file wikis on a standard web hosting platform for wikis I can edit and everyone else can read. I am gradually developing methods to help turn this method into fully collaborative system but this will take time.
Jed I think has the most advanced experience with publishing node on the internet but I believe security concerns remain.
So unfortunately you will need to describe more deeply your hosting requirements to get more focused advice on hosting.
Regards
Tony