There are rumors that there are some good trout streams up that way, but no one will seem to let you know where they are. They are all called noseeum creek or fishless run when you talk to anyone from up there. Let us know if it works out for you. It's the right distance for a weekend trip.
Considering the distance from DC being similar I would look up toward central PA and Penns Creek or the Little Juniata. Just avoid going when Penn State has a home game. Lodging becomes a bit scarce up there.
Carl