I may go up on Saturday, but I haven't decided. I am expecting a lot of unmasked people but plenty of people with masks. These types of crowds are where it really makes sense.
I will be exhibiting at the Maryland show on the 19th and don't have any concerns about that one.
I'm not a huge fan of the Lancaster show. There are a lot of bigger exhibitors. A few demonstrations at the casting pond and some good fly tiers, but the smaller vendors/used gear is priced out of the hall. If you've never been to a big, fancy show, it's definitely worth the trip.
The Maryland fly fishing show has been moved from Towson to Aberdeen this year. While Aberdeen is a bit further, the venue is bigger and should be easier to get in and out of. It will have a lot more used and vintage equipment, and probably good deals on old fly boxes that are filled with flies (I know some people who stock up on flies by buying old fly boxes at these events)