The Smokies, Jackson and Whitetop Laurel are good options, but here are a couple more:
- Rent a house near Shenandoah National Park and drive/hike to Brook Trout streams in the area (a bunch of places to search for house: Syria, Crozet, Charlottesville, Harrisonburg, etc.--reference books or online maps to find local streams)
- South Holston/Watauga Rivers near Bristol, TN: I'd hire a guide to float, it can be a lot more productive than wading (I've used Teo Whitlock and one of the guys from Southern Drifters Outfitters)
- Savage River/North Branch Potomac: Not in your desired area (Western Maryland) but good rivers to wade
- New River near Galax, VA: Good smallmouth fishing but may be early in the year to wade
Hope this helps.
Dalton