Hi Paul,
In a normal configuration apache keeps ~7 instances alive. When there are more concurrent users than this number, apache forks more processes. The number of concurrent users will be limited when apache fails to fork a new process i.e. no more memory is left. mod_wsgi and SymPy has nothing to do with it.
I would suggest you to use HAProxy and distribute your app over multiple instances or you can use a really high end server.
Regards
Sudhanshu Mishra
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