I've got an older 58cm Homer that takes a 650b wheel, and am currently riding the 42mm Rene Herse Pumpkin Ridge with endurance casings. For the mixed terrain (50/50 road and dirt) it sees I think they're a wonderful complement to the bike. On the Homer, I run the tires with tubes. However, on two other bikes, I use the regular casing Reneherese tires (tubeless) and haven't had any flating issues that were abnormal on any of them. What was the extent of the issues you had with your Rene Herse tires?
I find that tires are as much a personal preference as they are a poorly controlled case study performed by each of us as riders. Myself very much included. What one person likes, another has had terrible flatting issues with, and what one person finds a fast and comfortable ride with great cornering, another finds a harsh or sluggish ride. (Tire pressure?...) FWIW, other tires I've had good luck with have been the Ultra Dynamico and Terravail offerings, but not as much success with WTB or Continental over the years. But of course, your mileage may vary.
Collin