Hi Justin. You can definitely mix and match. You can use pretty much any Shimano trigger shifter with any Shimano rear derailleur as long as the number of shifter speeds corresponds to the number of cassette gears. There are a few exceptions, like vintage Shimano or too low or too high number of speeds. But for the stuff Rivendell sells, the various shifters are compatible with the various derailleurs. They do not have to be part of the same group. The derailleurs themselves don't care about which mechanism is actuating the cable travel. Just be sure the number of speeds on the shifters matches the number of cassette sprockets: 8-speed shifter with 8-speed cassette, 9-speed shifter with 9-speed cassette, etc. for proper indexing. And if you happen to run the trigger shifter with a Rapid Rise derailleur, the numbers on the shifter indicators will be reversed relative to non-Rapid Rise (1 will be 9, 2 will be 8, etc.), but otherwise the shifting will function the same.