I have a 2014-ish sidepull Sam Hillborne that I picked up off this list in spring 2018. The bike came to me with Paul Racers and I rode tires as big as 700x44. After seeing Ultraromance's 650b conversion on his Sam H, I thought I'd give that configuration a go (because there's just something about fat knobby tires on a road bike that get's me goin').
In early 2019 I had a local framebuilder add canti posts at 650b placement for about $150. Nervous about committing to 650b on this bike because of the reasons Bill and others mention (bb drop, pedal strike, etc), I purchased Paul Motolites so I could swap between 700c and 650b if/when needed. I managed to squeeze in 27.5x2.1" Schwalbe Thunderburts with very little clearance, but went on a few bikepacking trips with this setup. I've since added a Crust Evasion to my lineup (which also has two wheelsets, *facepalm*) and have made my Sam H a dedicated 700c bike... for now.
I remember Blahgs from 1-2 years back where Roman @ Riv did the same thing with his Sam H. One Blahg showed him dimpling his chainstays so he could more easily squeeze a 2.1" tire in there. To this day I'm still waiting for a feature of that bike on a Blahg or a newsletter, but it looks like that day may never come.
Regarding pedal strike- yeah, there was some, but I have a pretty high tolerance for it so didn't really notice a huge difference. The trails around here are pretty rocky and rooty so if I'm riding my SamH on trails, there's going to be pedal strike no matter what I do. The other thing people often ask is about mechanical advantage with the Motolites. I mean, sure, there's probably better stopping power with 650b wheels/pad placement, but my bike stops just fine with the pads adjusted for 700c.
Overall the 650b conversion was a fun project and adds to my ability to tinker with that bike- BUT, not night & day to the point where I'd wholeheartedly recommend.
Erik, Philly