Yes, I am running with tubes and the Dyad is at the lower end of RH's recommended rim width, but I've seen Jan state several times that rim width doesn't matter with supple tires, so I wasn't concerned about it. The narrower rim may require a higher pressure, like you and others have suggested.
Also, the Antelope Hill is RH's road tread, although the thought has passed thru my mind that maybe the knobby version wouldn't have this issue.
One thing that strikes me (and surprises me) is that the Antelope Hill is HUGE, even on a Dyad rim. I've looked at tons of photos of Antelope Hills and Snoqualmie Passes on bikes, to get an idea of their relative sizes, but I'm used to tires measuring below their stated widths, sometimes by quite a lot.
The RH tires do live up to their "low rolling resistance" reputation. Man, they feel fast. Also, my last tire was a 53 mm Nine Line knobby, which was surprisingly fast for a big knobby, but in a really slow speed, tight angle turn (which I do a lot of in my riding), I often felt like the front tire/wheel was in the way and the bike was about to "trip" over them, if that makes sense. The Antelope Hill, although it's bigger, doesn't feel that way and in fact, significantly reduced my tight turn radius. I don't know if that's an intertia thing due to lower overall weight, or something else. But I do like it.