I run 43mm Gravelkings on my 55 canti sam w/fenders and they fit fine. I think the 50mm would probably squeeze in (assuming they are a slick tire, and not knobby), but you'd be leaving very little room for any debris. That might be an issue if your wheel is ever slightly out of true or dish. And I probably wouldn't ride off road with them.
There hasn't been word about whether the new run of Sams will be identical to the last. The current trend seems to be more and more clearance in each model year, so you may be in luck.
Nathan in PDX