Hi Barry -
You need to understand a core feature of Qubes - the use of Templates to
back individual qubes. There is a good explanation here:
www.qubes-os.org/doc/getting-started
So you can make a permanent change by altering the Template on which
your sys-net is based.
It's also possible to make individual changes by putting them in to
/rw/config/rc.local in the qube - Look here:
www.qubes-os.org/doc/config-files/
Remember to chmod +x rc.local if you want the changes to take effect on
boot.
There is another mechanism - the use of bind-dirs to have a persistent
config file in a Template-based qube. Again, that's covered inn the
docs.
cheers
unman