Also:
1) Is it a composite USB device (multiple services on a single endpoint, not a hub).
2) Is one or more service based on the HID interface and possibly blocked as it is seen as a keyboard?
Similar issues occur with yubikeys, I believe there are documents that may help on the qubes-os.org site related to making yubikeys work.
Brendan
OTP won't , if the key does more than U2F you may need to get a
configuration application for the key and make sure it's U2F only
slot 1 , 2 etc