Hi Davide,
Yes, you can set up a co-simulation between a Chrono system and a DEM-E granular system. DEM-E should also work with a single GPU.
Another alternative is to use the Chrono::GPU module in Chrono (which is the precursor to DEM-E). That is a (single) GPU-based DEM simulation tool, but has certain limitations compared to DEM-E (most notably is that it can only work with mono-disperse granular material).
For a CPU based solution, you can use the Chrono::Multicore module which is an OpenMP-parallelized solver for granular and multibody dynamics. While performance is lower than with a GPU code, Chrono::Multicore allows monolithic simulation of vehicles on granular terrain (no need to set up a co-simulation), allows you to use arbitrary particle shapes (but beware that more complex particle geometries will obviously affect performance), and supports both smooth and non-smooth contact formulations (while all GPU-based DEM solvers only support the smooth contact formulation).
For vehicle-terrain interaction problems, you may want to also look at the co-simulation framework in Chrono::Vehicle which allows you to co-simulate a Chrono vehicle model with any of the terrain systems (rigid or deformable) available in Chrono (currently, DEM-E is not supported but I may add that sometime in the future).
--Radu
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