By large do you mean the sampling resolution of the vdb volume, or its spatial extent?
More or less the sampling rate (or adaptivity, etc.) of the underlying source of volumetric data is irrelevant to pbrt’s volume scattering code. (For example, there is a Cloud medium in there based on perlin noise that is evaluated on the fly, at the exact lookup point.) You can think of the volume scattering code integrating over a continuous ray, looking up randomly-sampled points along it. If the bounding box of the volume is bigger, pbrt will take more samples, and if the medium is denser, pbrt will take more samples.