No guideline, really.
There are very small real problems (a few dozen variables and constraints) for which the optimal has still not be proven.
One can build almost arbitrarily small problems that are arbitrarily hard.
That's the general case. Exponential in the worst case.
Then each subclass of problems behaves differently. But the algorithm is still exponential, and the underlying simplex has O(number of constraints * log(number of variables)) iterations, with each iteration being O(n^2) or O(n^3).
This gives you a lower bound on the complexity of MIP.
So, if you multiply time spent by 60, I'd expect no more than a possible 5x increase in size.
However, you may be able to discover dominating constraints, some clever preprocessing, and abandon the need for a proven optimal, and you may get better speed in the end.