A flow 'sees' a 3D shape. Perhaps we call that shape a wing.
The flow doesn't care how we define or perceive the shape. It only
cares about the final shape. The definition or perception of the
shape is an abstraction that is useful to humans -- the flow doesn't
care.
Lets start with OpenVSP's coordinate system. X generally runs nose to
tail. Y generally runs out the right wing. Z is up. You can rotate
your aircraft so this is not strictly true, but it is close enough.
Imagine a swept wing. Cut that wing with a cutting plane that is
parallel to the X-Z plane. The resulting shape is airfoil-like.
I speak in generalities here because these results are dependent on
the details of the wing -- taper, twist, spanwise airfoil variation,
etc.
Now, cut that wing with a cutting plane that is perpendicular to the
swept c/4 line. The resulting shape is airfoil-like.
These two airfoils are most likely not the same. One will have a
longer chord -- while the dimensional thickness will be very similar.
So, obviously the airfoils have different t/c. In simple cases, the
airfoils are related by stretching in one direction. If you have
strong taper or spanwise airfoil variation, then their relationship is
non-trivial.
Rob