HI Martin
Gain is a zwo setting between 0-100. I"m not sure how ZWO measures it and what that number actually represents. Gain is just signal amplification, including the noise, so it's not really changing the ratio. If you want to better understand camera gain in general there are a lot of videos and posts available on that.
For your SNR results, I would stick with what you are using. Those SNR numbers are good, and better SNR is not going to make much of any difference to your guiding.
Most folks aren't fiddling with gain settings in their guide cameras. As you've said, the most important is SNR, and it sounds like you are doing quite well in that department
The camera works in either 8 or 16 bit quite well, although with multi-star guiding, i personally don't think 16 bit really buys you much more