thanks for reply Brian, much appreciated.
re your numbered points:
1 - I use NINA and neglected to auto restart guiding which probably explains the guide star loss. I have rectified that in NINA.
2- I have now enabled auto backlash compensation, thank you for that. I used NINA's three point polar alignment tool and it indicated PA was within 10 arcmin (for each of az & alt) which I hoped would be good enough (as on a different mount - mesu 200, i have PA error of 6 arcmin and PHD2 does a great job with that - uses oag on an sct)
3- does this indicate a manufacturing tolerance or more likely my guidescope is misaligned in some way? Can I do iterations of measure & adjust to make the orthogonality alignment better?
4 - the mount is a skywatcher star adventurer gti, max payload 5kg (my current payload is a canon 1000d with 200mm lens + guidescope - weight 2.5kg)
I note with the mount that the RA backlash seems minimal when unpowered and moved gently by hand, but when doing the same with the DEC axis, there's a noticeable movement I'd say probably one degree which seems large, but I have no experience of geared mounts, just the zero backlash mesu.
I'll do as you suggest re calibration assistant and guiding assistant and see how that goes.
thanks again,
Paul