This looks like a mess. The profile name is the same between 8/21 and 9/16 - probably the same profile - but the cameras are different:
8/21: Camera = ZWO ASI662MC, gain = 44, full size = 1920 x 1080, (probably the correct camera)
9/16: Camera = Camera = ZWO ASI2600MM Pro, gain = 44, full size = 6248 x 4176 (probably not the right camera)
It looks very much like the OP hasn't used the new-profile-wizard to carefully create a new profile for his modified set-up. As a result, the calibration step-size is currently wrong by at least 2x which is why the Calibration Assistant barked about the result ("steps"). The guiding actually doesn't look very good either but I don't think this is worth pursuing until all these setup-related things are straightened out.
Bruce