No this isn't possible I'm afraid - the browser doesn't have access to the local filesystem for good security reasons, but also, when you 'browserify' or package up node JS modules to be run on the client, they must necessarily use just JavaScript, since that's all the browser can execute. It cannot execute arbitrary C code on the host platform!
There are all sorts of security reasons why this isn't possible.
However, what is it you are trying to do? What do you want from, or to do to, the file system?