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Okechukwu Ogah
Jul 5, 2021, 10:20:28 AM7/5/21
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Dr O.S Ogah. MBBS, MSc, PhD, FWACP, FACP, FESC.
A. Senior Lecturer
Cardiology Unit, Department of Medicine,
Faculty of Clinical Sciences
College of Medicine,
University of Ibadan, NIGERIA
B. Honorary Consultant Physician/Cardiologist,
Cardiology Unit,
Department of Medicine
University College Hospital Ibadan, NIGERIA
PERSONAL POSTAL ADDRESS
P.O BOX 14343, UNIVERSITY OF IBADAN POST OFFICE
IBADAN, NIGERIA
C. Bernard Lown Visiting Scholar in Cardiovascular Health
Department of Global Health and Population
Harvard T.H. Chan School of Public Health
Email: oo...@hsph.harvard.edu
D. Adjunct Researcher,
Institute of Advanced Medical Research and Training (IAMRAT)
College of Medicine, University of Ibadan, NIGERIA
E. Affiliate Member,
The Hatter Institute for Cardiovascular Research in Africa (HICRA)
4th Floor Chris Barnard Building
Faculty of Health Sciences
University of Cape Town
Private Bag X3 7935
Observatory, SOUTH AFRICA
Faculty of Health Sciences
University of Cape Town
Private Bag X3 7935
Observatory, SOUTH AFRICA
F. National President,
Nigerian Cardiac Society
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"For with thee is the fountain of life: in thy light shall we see light." Psalm 36:9
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From: Google Scholar Alerts <scholarale...@google.com>
Date: Mon, Jul 5, 2021 at 11:04 AM
Subject: Recommended articles
To: <osoga...@gmail.com>
From: Google Scholar Alerts <scholarale...@google.com>
Date: Mon, Jul 5, 2021 at 11:04 AM
Subject: Recommended articles
To: <osoga...@gmail.com>
[HTML] Transition to adulthood and transfer to adult care of adolescents with congenital heart disease: a global consensus statement of the ESC Association of …
P Moons, EL Bratt, J De Backer, E Goossens… - European Heart Journal, 2021
The vast majority of children with congenital heart disease (CHD) in high-income
countries survive into adulthood. Further, paediatric cardiac services have expanded
in middle-income countries. Both evolutions have resulted in an increasing number …
countries survive into adulthood. Further, paediatric cardiac services have expanded
in middle-income countries. Both evolutions have resulted in an increasing number …
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Vericiguat in Patients with Atrial Fibrillation and Heart Failure with Reduced Ejection Fraction: Insights from the VICTORIA trial
P Ponikowski, W Alemayehu, A Oto, MC Bahit, E Noori… - European journal of heart failure
Aims We evaluated the relation between baseline and new‐onset atrial fibrillation
(AF) and outcomes, and assessed whether vericiguat modified the likelihood of new‐
onset AF in patients with worsening heart failure (HF) with reduced ejection fraction …
(AF) and outcomes, and assessed whether vericiguat modified the likelihood of new‐
onset AF in patients with worsening heart failure (HF) with reduced ejection fraction …
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Clinical and prognostic values of urinary alpha1-microglobulin as a tubular marker in acute heart failure
S Ishiwata, Y Matsue, Y Nakamura, T Dotare… - International Journal of …, 2021
Background Although urinary alpha-1-microglobulin has been used as a marker of
tubular dysfunction, its clinical and prognostic values in patients with acute heart
failure have not been validated. Methods: We analyzed 623 patients (74±13 years …
tubular dysfunction, its clinical and prognostic values in patients with acute heart
failure have not been validated. Methods: We analyzed 623 patients (74±13 years …
| | | |
[PDF] Ferric carboxymaltose for the treatment of iron deficiency in heart failure: a multinational cost‐effectiveness analysis utilising AFFIRM‐AHF
P McEwan, P Ponikowski, JA Davis, G Rosano… - European Journal of Heart …, 2021
Aims Iron deficiency is common in patients with heart failure (HF). In AFFIRM‐AHF,
ferric carboxymaltose (FCM) reduced the risk of hospitalisations for HF (HHF) and
improved quality of life vs. placebo in iron‐deficient patients with a recent episode of …
ferric carboxymaltose (FCM) reduced the risk of hospitalisations for HF (HHF) and
improved quality of life vs. placebo in iron‐deficient patients with a recent episode of …
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Clinical Outcome Predictions for the VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA) Trial
RJ Mentz, H Mulder, A Mosterd, NK Sweitzer, J Butler… - Journal of Cardiac Failure, 2021
Background The prediction of outcomes in patients with heart failure (HF) may inform
prognosis, clinical decisions regarding treatment selection, and new trial planning.
The VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection …
prognosis, clinical decisions regarding treatment selection, and new trial planning.
The VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection …
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[PDF] Comparative analysis of phasic left atrial strain and left ventricular posterolateral strain pattern to discriminate Fabry cardiomyopathy from other forms of left ventricular …
D Frumkin, I Mattig, M Al-Daas, NM Laule… - Authorea Preprints, 2021
Background 'Classical'echocardiographic signs of Fabry cardiomyopathy (FC), such
as left ventricular hypertrophy (LVH), posterolateral strain deficiency (PLSD) and
papillary muscle hypertrophy may have a limited diagnostic accuracy in clinical …
as left ventricular hypertrophy (LVH), posterolateral strain deficiency (PLSD) and
papillary muscle hypertrophy may have a limited diagnostic accuracy in clinical …
| | | |
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Okechukwu Ogah
Jul 11, 2021, 6:16:15 PM7/11/21
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[HTML] Characteristics of patients with acute heart failure in North Central Nigeria
JA Ogunmodede, PM Kolo, MO Bojuwoye, BF Dele-Ojo… - Research Journal of Health …, 2021
Objectives: Heart failure (HF) is an important cause of hospital admission in Nigeria.
HF is increasingly prevalent because the population is aging and HF epidemiology is
changing. We aimed at profiling the socio-demographic, clinical and …
HF is increasingly prevalent because the population is aging and HF epidemiology is
changing. We aimed at profiling the socio-demographic, clinical and …
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Rehabilitation Intervention in Older Patients With Acute Heart Failure With Preserved Versus Reduced Ejection Fraction
RJ Mentz, DJ Whellan, GR Reeves, AM Pastva… - JACC: Heart Failure, 2021
Objectives This study assessed for treatment interactions by ejection fraction (EF)
subgroup (≥ 45%[preserved EF (HFpEF); vs< 45%[reduced EF;(HFrEF)]).
Background The REHAB-HF trial showed that an early multidomain rehabilitation …
subgroup (≥ 45%[preserved EF (HFpEF); vs< 45%[reduced EF;(HFrEF)]).
Background The REHAB-HF trial showed that an early multidomain rehabilitation …
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Lung Ultrasound–Guided Emergency Department Management of Acute Heart Failure (BLUSHED-AHF): A Randomized Controlled Pilot Trial
PS Pang, FM Russell, R Ehrman, R Ferre, L Gargani… - JACC: Heart Failure, 2021
Objectives The goal of this study was to determine whether a 6-h lung ultrasound
(LUS)-guided strategy-of-care improves pulmonary congestion over usual
management in the emergency department (ED) setting. A secondary goal was to …
(LUS)-guided strategy-of-care improves pulmonary congestion over usual
management in the emergency department (ED) setting. A secondary goal was to …
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[HTML] Juggling While Dancing: The Complex Medical Management of Heart Failure With Reduced Ejection Fraction
NM Fine, MN Walsh - 2021
The management of patients with heart failure with reduced ejection fraction (HFrEF)
has evolved significantly over time, and these advancements are perhaps most
significant with respect to medical therapy. In addition to longstanding therapies …
has evolved significantly over time, and these advancements are perhaps most
significant with respect to medical therapy. In addition to longstanding therapies …
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The" Peptide for Life" Initiative: A Call for Action to Provide Equal Access for the Use of Natriuretic Peptides in the Diagnosis of Acute Heart Failure across Europe
A Bayes-Genis, JL Januzzi, AM Richards, H Arfsten… - European journal of heart …, 2021
The "Peptide for Life" Initiative: A Call for Action to Provide Equal Access for the Use
of Natriuretic Peptides in the Diagnosis of Acute Heart Failure across Europe. Eur J Heart
Fail. 2021 Jul 7. doi: 10.1002/ejhf.2293. Online ahead of print …
of Natriuretic Peptides in the Diagnosis of Acute Heart Failure across Europe. Eur J Heart
Fail. 2021 Jul 7. doi: 10.1002/ejhf.2293. Online ahead of print …
Okechukwu Ogah
Jul 13, 2021, 11:43:41 AM7/13/21
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fyi
[PDF] Prognostic Implications of Reductions in Heart Rates in Patients With Acute Heart Failure and Atrial Fibrillation
K Kida, T Kitai, N Suzuki, K Ashikaga, S Kou… - Circulation Journal, 2021
Background: Atrial fibrillation (AF) is a common arrhythmia in patients with acute
heart failure (AHF). Heart rate (HR) also changes significantly over time. However,
the association between changes in HR in AF patients and prognosis is uncertain …
heart failure (AHF). Heart rate (HR) also changes significantly over time. However,
the association between changes in HR in AF patients and prognosis is uncertain …
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Prevalence of Coronary Artery Disease and Coronary Microvascular Dysfunction in Patients With Heart Failure With Preserved Ejection Fraction
CJ Rush, C Berry, KG Oldroyd, JP Rocchiccioli… - JAMA Cardiology
Importance Coronary artery disease (CAD) and coronary microvascular dysfunction
(CMD) may contribute to the pathophysiologic characteristics of heart failure with
preserved ejection fraction (HFpEF). However, the prevalence of CAD and CMD …
(CMD) may contribute to the pathophysiologic characteristics of heart failure with
preserved ejection fraction (HFpEF). However, the prevalence of CAD and CMD …
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[PDF] Peripartum Cardiomyopathy.. A Mysterious Misfortune of Pregnancy!
S Dabbas, S Chiranjeevi, C Malozzi, B Omar
Discussion Peripartum cardiomyopathy (PPCM) is a rare form of DCM of uncertain
etiology which usually presents late in pregnancy or, more commonly, up to 5 months
postpartum [1]. PPCM is more common in females> 30 years of age, and in those …
etiology which usually presents late in pregnancy or, more commonly, up to 5 months
postpartum [1]. PPCM is more common in females> 30 years of age, and in those …
Okechukwu Ogah
Jul 18, 2021, 6:52:33 PM7/18/21
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Clinical and prognostic values of urinary alpha1-microglobulin as a tubular marker in acute heart failure
S Ishiwata, Y Matsue, Y Nakamura, T Dotare… - International Journal of …, 2021
Background Although urinary alpha-1-microglobulin has been used as a marker of
tubular dysfunction, its clinical and prognostic values in patients with acute heart
failure have not been validated. Methods: We analyzed 623 patients (74±13 years …
tubular dysfunction, its clinical and prognostic values in patients with acute heart
failure have not been validated. Methods: We analyzed 623 patients (74±13 years …
| | | |
[HTML] Delayed repolarization and ventricular tachycardia in patients with heart failure and preserved ejection fraction
JH Cho, D Leong, N Cuk, JE Ebinger, C Bresee… - PloS one, 2021
Sudden death is the most common mode of mortality in patients with heart failure and
preserved ejection fraction (HFpEF). Ventricular arrhythmias (VA) have been
suspected as the etiology but the supporting evidence in patients with HFpEF is …
preserved ejection fraction (HFpEF). Ventricular arrhythmias (VA) have been
suspected as the etiology but the supporting evidence in patients with HFpEF is …
nazeerabua
Jul 19, 2021, 1:31:35 AM7/19/21
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Received with thanks sir.
Kind regards
Dr Muhammad Nazir Shehu
Sent from my Galaxy
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Okechukwu Ogah
Jul 20, 2021, 9:40:49 AM7/20/21
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[PDF] Clinical Significance of the Fibrosis-4 Index in Patients with Acute Heart Failure Requiring Intensive Care
A Shirakabe, H Okazaki, M Matsushita, Y Shibata… - International Heart Journal, 2021
Summary The Fibrosis-4 (FIB4) index could indicate the liver fibrosis in patients with
chronic hepatic diseases. It was calculated using the following formula:(age×
aspartate aminotransferase [U/L])/(platelet count [103/μL]×√ alanine …
chronic hepatic diseases. It was calculated using the following formula:(age×
aspartate aminotransferase [U/L])/(platelet count [103/μL]×√ alanine …
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Right Heart Dysfunction and Readmission Risk across Left Ventricular Ejection Fraction Status in Patients with Acute Heart Failure
E Santas, G Miñana, P Palau, R de la Espriella… - Journal of Cardiac Failure, 2021
Background Right heart dysfunction (RHD) parameters are increasingly important in
heart failure (HF). This study aimed to evaluate the association of advanced RHD
with the risk of recurrent admissions across the spectrum of left ventricular ejection …
heart failure (HF). This study aimed to evaluate the association of advanced RHD
with the risk of recurrent admissions across the spectrum of left ventricular ejection …
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[PDF] Clinical utility of 12‐lead electrocardiogram in evaluating heart disease in patients with muscular dystrophy: Assessment of left ventricular hypertrophy, conduction …
A Nikhanj, H Yogasundaram, S Kimber, ZA Siddiqi… - Annals of Noninvasive …, 2021
Introduction Heart disease remains a leading cause of mortality in patients with
muscular dystrophy (MD), and cardiac assessment by standard imaging modalities is
challenging due to the prominence of physical limitations. Methods In this …
muscular dystrophy (MD), and cardiac assessment by standard imaging modalities is
challenging due to the prominence of physical limitations. Methods In this …
Okechukwu Ogah
Jul 22, 2021, 9:02:29 AM7/22/21
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fyi
Efficacy of dapagliflozin in heart failure with reduced ejection fraction according to body mass index
C Adamson, PS Jhund, KF Docherty, J Bělohlávek… - European Journal of Heart …, 2021
Background In heart failure with reduced ejection fraction (HFrEF), there is an
“obesity paradox”, where survival is better in patients with a higher body mass index
(BMI) and weight loss is associated with worse outcomes. We examined the effect of …
“obesity paradox”, where survival is better in patients with a higher body mass index
(BMI) and weight loss is associated with worse outcomes. We examined the effect of …
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Xin-Ji-Er-Kang Protects Myocardial and Renal Injury in Hypertensive Heart Failure in Mice
X Ling, H Chen, B Fu, C Ruan, MPK Zhou, Z Fang… - Phytomedicine, 2021
Abstract Background Xin-Ji-Er-Kang (XJEK) as a herbal formula of traditional
Chinese medicine (TCM) has shown the protective effects on myocardial function as
well as renal function in mouse models of myocardial infarction. Hypothesis/Purpose …
Chinese medicine (TCM) has shown the protective effects on myocardial function as
well as renal function in mouse models of myocardial infarction. Hypothesis/Purpose …
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Aortic and valvular heart diseases, cardiomyopathies and heart failure in pregnancy: Risk assessment and management
V Regitz-Zagrosek, J Krüger, K Sliwa - Herz, 2021
Women with known cardiovascular diseases (CVD) and a desire to have children
should receive a timely comprehensive counselling before becoming pregnant. This
is critical as the foundation for an informed decision-making process of the mother …
should receive a timely comprehensive counselling before becoming pregnant. This
is critical as the foundation for an informed decision-making process of the mother …
Okechukwu Ogah
Jul 27, 2021, 11:40:40 AM7/27/21
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[PDF] Association Between Albumin-Bilirubin Score at Admission and In-Hospital Mortality in Patients with Acute Heart Failure
T Kawata, A Ikeda, H Masuda, S Komatsu - International Heart Journal, 2021
Liver dysfunction is one of the most recognized complications in patients with acute
heart failure (HF) and therefore a liver function score may be useful for risk-
stratification in those patients. Recently, the albuminbilirubin (ALBI) score was …
heart failure (HF) and therefore a liver function score may be useful for risk-
stratification in those patients. Recently, the albuminbilirubin (ALBI) score was …
| | | |
[PDF] Severe peripartum cardiomyopathy complicated by COVID‐19 infection and small intestinal obstruction
E Abdulraheem, M Shaikhoun, D Kung - Clinical Case Reports, 2021
COVID‐19 infection can be a possible trigger for peripartum cardiomyopathy.
Multidisciplinary teamwork was crucial for the favorable outcome in our patient. Small
bowel strangulation is a rare complication post‐cesarean section.
Multidisciplinary teamwork was crucial for the favorable outcome in our patient. Small
bowel strangulation is a rare complication post‐cesarean section.
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[PDF] Effect of the Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin for Heart Failure With Preserved Ejection Fraction in Patients With Type 2 Diabetes
T Ueda, S Kasama, M Yamamoto, T Nakano… - Circulation Reports, 2021
Background: The efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors in
elderly patients with heart failure with preserved ejection fraction (HFpEF) remains
unclear. Methods and Results: In a multicenter, controlled trial, the CANONICAL …
elderly patients with heart failure with preserved ejection fraction (HFpEF) remains
unclear. Methods and Results: In a multicenter, controlled trial, the CANONICAL …
Jayne Ajuluchukwu
Jul 28, 2021, 12:06:36 PM7/28/21
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Always appreciated. Thank you so much, Presido
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Okechukwu Ogah
Jul 29, 2021, 11:00:19 AM7/29/21
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[HTML] Activity of the adrenomedullin system to personalise post-discharge diuretic treatment in acute heart failure
N Kozhuharov, L Ng, D Wussler, I Strebel, Z Sabti… - Clinical Research in …, 2021
Background Quantifying the activity of the adrenomedullin system might help to
monitor and guide treatment in acute heart failure (AHF) patients. The aims were to
(1) identify AHF patients with marked benefit or harm from specific treatments at …
monitor and guide treatment in acute heart failure (AHF) patients. The aims were to
(1) identify AHF patients with marked benefit or harm from specific treatments at …
| | | |
Xin-Ji-Er-Kang Protects Myocardial and Renal Injury in Hypertensive Heart Failure in Mice
X Ling, H Chen, B Fu, C Ruan, MPK Zhou, Z Fang… - Phytomedicine, 2021
Abstract Background Xin-Ji-Er-Kang (XJEK) as a herbal formula of traditional
Chinese medicine (TCM) has shown the protective effects on myocardial function as
well as renal function in mouse models of myocardial infarction. Hypothesis/Purpose …
Chinese medicine (TCM) has shown the protective effects on myocardial function as
well as renal function in mouse models of myocardial infarction. Hypothesis/Purpose …
| | | |
[HTML] The clinical and prognostic value of late Gadolinium enhancement imaging in heart failure with mid-range and preserved ejection fraction
G van Woerden, DJ van Veldhuisen, TM Gorter… - Heart and vessels, 2021
Heart failure (HF) with mid-range or preserved ejection fraction (HFmrEF; HFpEF) is
a heterogeneous disorder that could benefit from strategies to identify
subpopulations at increased risk. We tested the hypothesis that HFmrEF and HFpEF …
a heterogeneous disorder that could benefit from strategies to identify
subpopulations at increased risk. We tested the hypothesis that HFmrEF and HFpEF …
| | | |
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Okechukwu Ogah
Jul 31, 2021, 7:20:36 PM7/31/21
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Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced …
AD DeVore, BB Granger, GC Fonarow, HR Al-Khalidi… - JAMA, 2021
Importance Adoption of guideline-directed medical therapy for patients with heart
failure is variable. Interventions to improve guideline-directed medical therapy have
failed to consistently achieve target metrics, and limited data exist to inform efforts to …
failure is variable. Interventions to improve guideline-directed medical therapy have
failed to consistently achieve target metrics, and limited data exist to inform efforts to …
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Anesthetic management for the peripartum care of women with fontan physiology
M McCabe, N An, J Aboulhosn, J Schwarzenberger… - International Journal of …, 2021
Background As outcomes for surgical palliation have improved, women with single
ventricle congenital heart disease are surviving into their reproductive years and may
become pregnant. The cardiovascular changes of pregnancy may stress the Fontan …
ventricle congenital heart disease are surviving into their reproductive years and may
become pregnant. The cardiovascular changes of pregnancy may stress the Fontan …
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Peripartum echocardiographic changes in women with hypertensive disorders of pregnancy
V Giorgione, J O'Driscoll, CM Coutinho, C Di Fabrizio… - Ultrasound in Obstetrics & …
Objectives Women with hypertensive disorders of pregnancy (HDP) present with
evidence of significant myocardial dysfunction on echocardiographic assessment at
the time of diagnosis. Birth not only cures the syndrome of HDP, but is also …
evidence of significant myocardial dysfunction on echocardiographic assessment at
the time of diagnosis. Birth not only cures the syndrome of HDP, but is also …
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[HTML] Cost-effectiveness of Dapagliflozin for the Treatment of Heart Failure With Reduced Ejection Fraction
N Isaza, P Calvachi, I Raber, CL Liu, BK Bellows… - JAMA Network Open, 2021
Importance Heart failure with reduced ejection fraction produces substantial
morbidity, mortality, and health care costs. Dapagliflozin is the first sodium-glucose
cotransporter 2 inhibitor approved for the treatment of heart failure with reduced …
morbidity, mortality, and health care costs. Dapagliflozin is the first sodium-glucose
cotransporter 2 inhibitor approved for the treatment of heart failure with reduced …
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Cardiac contractility modulation in patients with ischemic versus non-ischemic cardiomyopathy: Results from the mainined observational study
C Fastner, G Yuecel, B Rudic, G Schmiel, M Toepel… - International Journal of …, 2021
Background Cardiac contractility modulation (CCM) is an FDA-approved device-
based therapy for patients with systolic heart failure and normal QRS complex who
are symptomatic despite optimal drug therapy. The purpose of this study was to …
based therapy for patients with systolic heart failure and normal QRS complex who
are symptomatic despite optimal drug therapy. The purpose of this study was to …
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[HTML] Is It Time for a New Standard Therapy for Heart Failure with Reduced Ejection Fraction?
ETO Correia, LMS Barbetta, ET Mesquita - Arquivos Brasileiros de Cardiologia, 2021
Heart failure (HF) with reduced ejection fraction (HFrEF) leads to mortality and
impairment in one's quality of life, and causes a major impact on the healthcare
system. Despite trials showing the benefits of angiotensin receptor–neprilysin …
impairment in one's quality of life, and causes a major impact on the healthcare
system. Despite trials showing the benefits of angiotensin receptor–neprilysin …
Okechukwu Ogah
Aug 7, 2021, 3:33:38 PM8/7/21
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[PDF] Rational and design of SATRACD study: detecting subclinical anthracycline therapy related cardiac dysfunction in low income country
W Zhang, F Azibani, E Okello, J Kayima, V Walusansa… - African Health Sciences, 2021
Background: Anthracycline therapy-related cardiac dysfunction (ATRCD) is the most
notorious adverse side-effect of chemotherapy. It has become a significant
cardiovascular health concern for long-term cancer survivors. With the emerging …
notorious adverse side-effect of chemotherapy. It has become a significant
cardiovascular health concern for long-term cancer survivors. With the emerging …
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[PDF] Association between intestinal oedema and oral loop diuretic resistance in hospitalized patients with acute heart failure
Y Ikeda, S Ishii, K Maemura, T Oki, M Yazaki, T Fujita… - ESC Heart Failure, 2021
Aims Intestinal oedema is one of the manifestations associated with right‐sided heart
failure (HF), which is known to be associated with poorer patient outcomes. We
attempted to reveal the association between intestinal oedema and diuretic …
failure (HF), which is known to be associated with poorer patient outcomes. We
attempted to reveal the association between intestinal oedema and diuretic …
| | | |
[PDF] Prognostic Value of Minimal Left Atrial Volume in Heart Failure With Preserved Ejection Fraction
SH Shin, B Claggett, RM Inciardi, ABS Santos, SJ Shah… - Journal of the American …, 2021
Background Maximal left atrial (LA) volume is reported by most echocardiography
laboratories and is associated with clinical outcomes in patients with heart failure
(HF). Recent studies suggest that minimal LA volume may better reflect left …
laboratories and is associated with clinical outcomes in patients with heart failure
(HF). Recent studies suggest that minimal LA volume may better reflect left …
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[PDF] Association Between Albumin-Bilirubin Score at Admission and In-Hospital Mortality in Patients with Acute Heart Failure
T Kawata, A Ikeda, H Masuda, S Komatsu - International Heart Journal, 2021
Liver dysfunction is one of the most recognized complications in patients with acute
heart failure (HF) and therefore a liver function score may be useful for risk-
stratification in those patients. Recently, the albuminbilirubin (ALBI) score was …
heart failure (HF) and therefore a liver function score may be useful for risk-
stratification in those patients. Recently, the albuminbilirubin (ALBI) score was …
| | | |
[PDF] Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy
E Sommariva, I Stadiotti, M Casella, V Catto, AD Russo… - EMBO Molecular Medicine
Arrhythmogenic cardiomyopathy (ACM) is hallmarked by ventricular fibro-adipogenic
alterations, contributing to cardiac dysfunctions and arrhythmias. Although
genetically determined (eg, PKP2 mutations), ACM phenotypes are highly variable …
alterations, contributing to cardiac dysfunctions and arrhythmias. Although
genetically determined (eg, PKP2 mutations), ACM phenotypes are highly variable …
Okechukwu Ogah
Aug 13, 2021, 1:47:43 PM8/13/21
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[PDF] Angiotensin II‐induced natriuresis is attenuated in knockout mice lacking the receptors for tumor necrosis factor‐α
DSA Majid, A Castillo - Physiological Reports, 2021
Intravenous infusion of relatively higher doses of angiotensin II (AngII) elicits
natriuresis as opposed to its usual anti‐natruretic response. As AngII can induce
tumor necrosis factor‐α (TNFα) production which elicits natriuresis via its action on …
natriuresis as opposed to its usual anti‐natruretic response. As AngII can induce
tumor necrosis factor‐α (TNFα) production which elicits natriuresis via its action on …
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Safety of Endomyocardial Biopsy in New-Onset Acute Heart Failure Requiring Veno-Arterial Extracorporeal Membrane Oxygenation
RMA van der Boon, WK den Dekker, CL Meuwese… - Circulation: Heart Failure, 2021
Background: Endomyocardial biopsy (EMB) has an important role in determining the
pathogenesis of new-onset acute heart failure (new-AHF) when noninvasive testing
is impossible. However, data on safety and histopathologic outcomes in patients …
pathogenesis of new-onset acute heart failure (new-AHF) when noninvasive testing
is impossible. However, data on safety and histopathologic outcomes in patients …
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The prognostic impact of uric acid in acute heart failure according to coexistence of diabetes mellitus
C Cidade-Rodrigues, FM Cunha, C Elias, D Oliveira… - Nutrition, Metabolism and …, 2021
ABSTRACT BACKGROUND AND AIMS Increased uric acid levels predict higher
mortality in heart failure (HF) patients. Patients with diabetes mellitus (DM) appear to
have increased xanthine oxidase activity. We aimed to study if the association …
mortality in heart failure (HF) patients. Patients with diabetes mellitus (DM) appear to
have increased xanthine oxidase activity. We aimed to study if the association …
| | | |
[HTML] Empagliflozin in Heart Failure With Predicted Preserved Versus Reduced Ejection Fraction: Data From the EMPA-REG OUTCOME Trial
G Savarese, A Uijl, LH Lund, SD Anker, F Asselbergs… - Journal of Cardiac Failure, 2021
ABSTRACT Background In the EMPA-REG OUTCOME trial, ejection fraction (EF)
data were not collected. In the subpopulation with heart failure (HF), we applied a
new predictive model for EF to determine the effects of empagliflozin in HF with …
data were not collected. In the subpopulation with heart failure (HF), we applied a
new predictive model for EF to determine the effects of empagliflozin in HF with …
| | | |
Okechukwu Ogah
Aug 17, 2021, 3:04:40 PM8/17/21
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fyi
Frequency of Peripartum Cardiomyopathy Among Women With Idiopathic Dilated Cardiomyopathy
WC Roberts, M Jeong - The American Journal of Cardiology, 2021
Among women with idiopathic dilated cardiomyopathy (IDC), the percent who
develop heart failure (HF) in the peripartum period (during pregnancy or within 6
months of parturition) compared with those women who develop HF outside the …
develop heart failure (HF) in the peripartum period (during pregnancy or within 6
months of parturition) compared with those women who develop HF outside the …
| | | |
Multi-Nephron Segment Diuretic Therapy to Overcome Diuretic Resistance in Acute Heart Failure: A Single-Center Experience
ZL Cox, BA Sarrell, MK Cella, B Tucker, JP Arroyo… - Journal of Cardiac Failure, 2021
Background The concept of multi-nephron segment diuretic therapy (MSDT) has
been recommended in severe diuretic resistance (DR) with only expert opinion and
case-level evidence. The purpose of this study was to investigate the safety and …
been recommended in severe diuretic resistance (DR) with only expert opinion and
case-level evidence. The purpose of this study was to investigate the safety and …
| | | |
[HTML] Iron therapy in iron-deficiency patients with heart failure with preserved ejection fraction: A protocol for meta-analysis
H Fukuta, H Hagiwara, T Kamiya - Medicine, 2021
Background: Nearly half of patients with heart failure (HF) have preserved ejection
fraction (EF) and the mortality and morbidity of patients with HF with preserved EF
(HFpEF) are high. However, there is no established therapy to improve survival in …
fraction (EF) and the mortality and morbidity of patients with HF with preserved EF
(HFpEF) are high. However, there is no established therapy to improve survival in …
| | | |
Towards an improved and personalized risk stratification of sudden cardiac death in dilated non-ischaemic cardiomyopathy: is the time for ejection fraction coming to …
A Berruezo, B Jáuregui, D Penela - European Heart Journal-Cardiovascular Imaging, 2021
Dilated non-ischaemic cardiomyopathy (NIDCM) is one of the most common
cardiomyopathies with an estimated prevalence in the range of 1–2 in 400
individuals. 1 Ventricular arrhythmias (VA) manifesting as sudden cardiac death …
cardiomyopathies with an estimated prevalence in the range of 1–2 in 400
individuals. 1 Ventricular arrhythmias (VA) manifesting as sudden cardiac death …
| | | |
[PDF] Acute pleiotropic effects of dapagliflozin in type 2 diabetic patients with heart failure with reduced ejection fraction: a crossover trial
F Ilyas, L Jones, SL Tee, M Horsfall, A Swan… - ESC Heart Failure, 2021
Aims This study aimed to explore the rapid effects of dapagliflozin in heart failure with
reduced ejection fraction (HFrEF). Methods and results We studied the functional,
echocardiographic, electrophysiological, lung ultrasound, ambulatory blood pressure …
reduced ejection fraction (HFrEF). Methods and results We studied the functional,
echocardiographic, electrophysiological, lung ultrasound, ambulatory blood pressure …
| | | |
Clinical Outcomes, Echocardiographic Findings, and Care Quality Metrics for People Living with HIV and Rheumatic Heart Disease in Uganda
AY Chang, J Rwebembera, E Bendavid, E Okello… - Clinical Infectious Diseases, 2021
Abstract Background Rheumatic Heart Disease (RHD) affects 41 million people
worldwide, mostly in low-and middle-income countries, where it is co-endemic with
HIV. HIV is also a chronic inflammatory disorder associated with cardiovascular …
worldwide, mostly in low-and middle-income countries, where it is co-endemic with
HIV. HIV is also a chronic inflammatory disorder associated with cardiovascular …
| | | |
B-PO04-170 SEX DIFFERENCES IN PATIENTS WITH ARRHYTHMOGENIC CARDIOMYOPATHY WITH RESPECT TO VENTRICULAR TACHYCARDIA …
M Laredo, B Belhassen, R Roudijk, G Peretto, G Zahavi… - Heart Rhythm, 2021
Background Arrhythmogenic cardiomyopathy (ACM) has an autosomal pattern of
inheritance. However, it is well known that the great majority of patients with ACM
and sustained VT with left bundle branch block (LBBB) morphology are males. ACM …
inheritance. However, it is well known that the great majority of patients with ACM
and sustained VT with left bundle branch block (LBBB) morphology are males. ACM …
Okechukwu Ogah
Aug 22, 2021, 4:08:01 AM8/22/21
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[HTML] Determinants of quality of life in acute heart failure patients with and without comorbidities: a prospective, observational study
JC van den Berge, LC van Vark, D Postmus… - European Journal of …, 2021
Aims The relation between non-cardiac comorbidities and health-related quality of
life (HRQoL) in patients with heart failure (HF) has been studied to a limited extent.
To investigate the HRQoL and their determinants among HF patients with and …
life (HRQoL) in patients with heart failure (HF) has been studied to a limited extent.
To investigate the HRQoL and their determinants among HF patients with and …
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[HTML] Sacubitril–valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction
AM Jackson, PS Jhund, IS Anand, HD Düngen… - European heart journal, 2021
Aims Patients with heart failure and preserved ejection fraction (HFpEF) frequently
have difficult-to-control hypertension. We examined the effect of neprilysin inhibition
on 'apparent resistant hypertension'in patients with HFpEF in the PARAGON-HF trial …
have difficult-to-control hypertension. We examined the effect of neprilysin inhibition
on 'apparent resistant hypertension'in patients with HFpEF in the PARAGON-HF trial …
Okechukwu Ogah
Aug 24, 2021, 9:33:52 AM8/24/21
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Moderate potassium lowering effect of exogenous atrial natriuretic peptide in patients with acute heart failure
M Konishi, E Akiyama, A Shibata, K Kida, S Ishii, Y Ikari… - Journal of Cardiology, 2021
Background Recent data suggest that the angiotensin receptor neprilysin inhibitor
modulates plasma levels of natriuretic peptides and attenuates the risk of
hyperkalemia in patients with heart failure (HF). However, the impact of natriuretic …
modulates plasma levels of natriuretic peptides and attenuates the risk of
hyperkalemia in patients with heart failure (HF). However, the impact of natriuretic …
| | | |
The prognostic impact of uric acid in acute heart failure according to coexistence of diabetes mellitus
C Cidade-Rodrigues, FM Cunha, C Elias, D Oliveira… - Nutrition, Metabolism and …, 2021
ABSTRACT BACKGROUND AND AIMS Increased uric acid levels predict higher
mortality in heart failure (HF) patients. Patients with diabetes mellitus (DM) appear to
have increased xanthine oxidase activity. We aimed to study if the association …
mortality in heart failure (HF) patients. Patients with diabetes mellitus (DM) appear to
have increased xanthine oxidase activity. We aimed to study if the association …
| | | |
[PDF] Blood pressure visit‐to‐visit variability and outcomes in patients with heart failure with preserved ejection fraction
Q Zhang, B Zhou, Y Ma, Y Hu, X Li, H Cong - ESC Heart Failure, 2021
Aims Previous studies report that blood pressure (BP) variability is associated with
increased risk of adverse outcomes in patients diagnosed with cardiovascular
disease. However, studies have not fully explored this association in patients with …
increased risk of adverse outcomes in patients diagnosed with cardiovascular
disease. However, studies have not fully explored this association in patients with …
| | | |
Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice
YN Lin, T Mesquita, L Sanchez, YH Chen, W Liu, C Li… - European Heart Journal, 2021
Aims Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of
cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs)
secreted by cardiosphere-derived cells, immortalized, and engineered to express …
cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs)
secreted by cardiosphere-derived cells, immortalized, and engineered to express …
| | | |
Survival Association of Angiotensin Inhibitors in Heart Failure with Reduced Ejection Fraction: Comparisons Using Self-Identified Race and Genomic Ancestry
JA Luzum, O Edokobi, MP Dorsch, E Peterson, B Liu… - Journal of Cardiac Failure, 2021
Background: It remains unclear whether there is a racial disparity in the response to
angiotensin inhibitors in patients with heart failure with reduced ejection fraction
(HFrEF), and the role of genomic ancestry. Therefore, we compared survival …
angiotensin inhibitors in patients with heart failure with reduced ejection fraction
(HFrEF), and the role of genomic ancestry. Therefore, we compared survival …
Okechukwu Ogah
Aug 31, 2021, 5:39:20 PM8/31/21
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Peripartum Cardiomyopathy
AS Farrell, JA Kuller, SA Goldstein, SK Dotters-Katz - Obstetrical & gynecological …, 2021
Results The etiology of peripartum cardiomyopathy remains poorly defined, but
theories include genetic predisposition, as well as myocardial inflammation and
angiogenic dysregulation. Risk factors for this condition include hypertensive …
theories include genetic predisposition, as well as myocardial inflammation and
angiogenic dysregulation. Risk factors for this condition include hypertensive …
| | | |
Prevalence of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction
OF AbouEzzeddine, DR Davies, CG Scott, AU Fayyaz… - JAMA cardiology, 2021
Importance Heart failure (HF) with preserved ejection fraction (HFpEF) is common, is
frequently associated with ventricular wall thickening, and has no effective therapy.
Transthyretin amyloid cardiomyopathy (ATTR-CM) can cause the HFpEF clinical …
frequently associated with ventricular wall thickening, and has no effective therapy.
Transthyretin amyloid cardiomyopathy (ATTR-CM) can cause the HFpEF clinical …
| | | |
[PDF] ANMCO POSITION PAPER: Use of sacubitril/valsartan in hospitalized patients with acute heart failure
G Di Tano, A Di Lenarda, M Iacoviello, F Oliva… - European Heart Journal …, 2021
Abstract Sacubitril/valsartan (S/V) has been shown to reduce the risk of
cardiovascular death or heart failure hospitalization and improve symptoms in
chronic heart failure with reduced ejection fraction compared with enalapril. After 7 …
cardiovascular death or heart failure hospitalization and improve symptoms in
chronic heart failure with reduced ejection fraction compared with enalapril. After 7 …
| | | |
Empagliflozin in Heart Failure with a Preserved Ejection Fraction
SD Anker, J Butler, G Filippatos, JP Ferreira, E Bocchi… - New England Journal of …, 2021
Background Sodium–glucose cotransporter 2 inhibitors reduce the risk of
hospitalization for heart failure in patients with heart failure and a reduced ejection
fraction, but their effects in patients with heart failure and a preserved ejection …
hospitalization for heart failure in patients with heart failure and a reduced ejection
fraction, but their effects in patients with heart failure and a preserved ejection …
| | | |
[PDF] Hemoglobin and Clinical Outcomes in the VerICiguaT Global Study in Patients With Heart Failure and Reduced Ejection Fraction (VICTORIA)
JA Ezekowitz, Y Zheng, A Cohen-Solal, V Melenovský… - Circulation, 2021
Background: In the VICTORIA trial, anemia occurred more often in patients treated
with vericiguat (7.6%) than placebo (5.7%). We explored the association between
vericiguat, randomization hemoglobin, development of anemia and whether the …
with vericiguat (7.6%) than placebo (5.7%). We explored the association between
vericiguat, randomization hemoglobin, development of anemia and whether the …
| | | |
Peripartum cardiomyopathy and acute heart failure associated with prolonged tocolytic therapy in pregnancy: A case report
PC Li, HR Chang, SP Kao - Medicine, 2021
Rationale Peripartum cardiomyopathy (PPCM) is a rare and sometimes fatal systolic
heart failure that affects women during late pregnancy or the early postpartum period.
Heart failure symptoms can mimic the physiological changes of normal pregnancy …
heart failure that affects women during late pregnancy or the early postpartum period.
Heart failure symptoms can mimic the physiological changes of normal pregnancy …
| | | |
Sodium–glucose co-transporter-2 inhibitors eligibility in patients with heart failure with reduced ejection fraction
L Monzo, I Ferrari, F Cicogna, C Tota, L Calò - International Journal of Cardiology, 2021
Background The sodium–glucose co-transporter-2 (SGLT2) inhibitors dapagliflozin
and empagliflozin have been demonstrated to reduce adverse cardiovascular
outcomes in patients with heart failure with reduced ejection fraction (HFrEF). Limited …
and empagliflozin have been demonstrated to reduce adverse cardiovascular
outcomes in patients with heart failure with reduced ejection fraction (HFrEF). Limited …
| | | |
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failureDeveloped by the Task Force for the diagnosis and treatment of acute and …
TA McDonagh, M Metra, M Adamo, RS Gardner… - European Heart Journal, 2021
The aim of this ESC Guideline is to help health professionals manage people with
heart failure (HF) according to the best available evidence. Fortunately, we now have
a wealth of clinical trials to help us select the best management to improve the …
heart failure (HF) according to the best available evidence. Fortunately, we now have
a wealth of clinical trials to help us select the best management to improve the …
| | | |
Peculiarity of Peripartum Cardiomyopathy (PPCM)
Z El Abasse, ZH Amine, Y Tagmouti, L Azzouzi… - International Journal of …, 2021
Background: PeriPartum CardioMyopathy (PPCM) is a rare, unrecognized and a life-
threatening pregnancy-associated disease. It is established as left ventricular
dysfunction occurring in the last month of pregnancy or the first 5 months postpartum …
threatening pregnancy-associated disease. It is established as left ventricular
dysfunction occurring in the last month of pregnancy or the first 5 months postpartum …
| | | |
[PDF] Anesthetic Management of Patient with Preeclampsia, Pulmonary Edema, and Peripartum Cardiomyopathy in Pregnancy Undergoing Caesarean Section: A Case …
D Tavianto, RW Sudjud, PC Barliana, I Wijaya - 2021
Preeclampsia is a disease that occurs in pregnancy after 20 weeks of gestation with
manifestations involving multi organ systems such as pulmonary edema and
ventricle dysfunction. Cardiomyopathy is a heart disorder characterized by …
manifestations involving multi organ systems such as pulmonary edema and
ventricle dysfunction. Cardiomyopathy is a heart disorder characterized by …
Okechukwu Ogah
Sep 5, 2021, 5:00:00 AM9/5/21
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Clinical significance of the N-terminal pro-brain natriuretic peptide and B-type natriuretic peptide ratio in the acute phase of acute heart failure
T Sawatani, A Shirakabe, H Okazaki, M Matsushita… - European Heart Journal …, 2021
Aims Serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and B-type
natriuretic peptide (BNP) levels are rarely evaluated simultaneously in the acute
phase of acute heart failure (AHF). Method and results A total of 1207 AHF patients …
natriuretic peptide (BNP) levels are rarely evaluated simultaneously in the acute
phase of acute heart failure (AHF). Method and results A total of 1207 AHF patients …
| | | |
[PDF] Heart Failure and a Preserved Ejection Fraction: A Side-by-Side Examination of the PARAGON-HF and EMPEROR-Preserved Trials
M Packer, F Zannad, SD Anker - Circulation, 2021
DESIGN AND MAJOR FINDINGS OF THE PARAGON-HF AND
EMPERORPRESERVED TRIALS ALIGNED FOR THE SAME END POINT The
PARAGON-HF and EMPEROR-Preserved trials were designed to recruit similar …
EMPERORPRESERVED TRIALS ALIGNED FOR THE SAME END POINT The
PARAGON-HF and EMPEROR-Preserved trials were designed to recruit similar …
| | | |
[PDF] Effect of empagliflozin on worsening heart failure events in patients with heart failure and a preserved ejection fraction: the EMPEROR-Preserved trial
M Packer, J Butler, F Zannad, G Filippatos, JP Ferreira… - Circulation, 2021
Background: Empagliflozin reduces the risk of cardiovascular death or
hospitalization for heart failure in patients with heart failure and a preserved ejection
fraction, but additional data are needed about its effect on inpatient and outpatient …
hospitalization for heart failure in patients with heart failure and a preserved ejection
fraction, but additional data are needed about its effect on inpatient and outpatient …
| | | |
Non-invasive body surface electrocardiographic imaging for diagnosis of atrial cardiomyopathy
M Eichenlaub, B Mueller-Edenborn, H Lehrmann… - EP Europace, 2021
Aims Atrial cardiomyopathy (ACM) is associated with new-onset atrial fibrillation,
arrhythmia recurrence after pulmonary vein isolation (PVI) and increased risk for
stroke. At present, diagnosis of ACM is feasible by endocardial contact mapping of …
arrhythmia recurrence after pulmonary vein isolation (PVI) and increased risk for
stroke. At present, diagnosis of ACM is feasible by endocardial contact mapping of …
| | | |
[PDF] Applying the ESC 2016, H2FPEF, and HFA‐PEFF diagnostic algorithms for heart failure with preserved ejection fraction to the general population
J Nikorowitsch, R Bei der Kellen, P Kirchhof… - ESC Heart Failure, 2021
Aims Heart failure with preserved ejection fraction (HFpEF) is common in patients
presenting with dyspnoea. Recently, clinical tools were developed to facilitate the
diagnosis of HFpEF. Here, we apply the European Society of Cardiology (ESC) 2016 …
presenting with dyspnoea. Recently, clinical tools were developed to facilitate the
diagnosis of HFpEF. Here, we apply the European Society of Cardiology (ESC) 2016 …
| | | |
Successful pregnancy with left ventricular assist device failure in the setting of peripartum cardiomyopathy
A Vargas, S Armin, E Yeomans - Baylor University Medical Center Proceedings, 2021
Pregnancy is contraindicated for women with left ventricular dysfunction due to high
maternal and fetal mortality. We present a case of a pregnant 31-year-old woman
with a history of heart failure due to peripartum cardiomyopathy from a previous …
maternal and fetal mortality. We present a case of a pregnant 31-year-old woman
with a history of heart failure due to peripartum cardiomyopathy from a previous …
Jayne Ajuluchukwu
Sep 5, 2021, 1:50:10 PM9/5/21
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Thanks. interesting articles
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Okechukwu Ogah
Sep 5, 2021, 2:52:32 PM9/5/21
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Okechukwu Ogah
Sep 7, 2021, 11:21:46 AM9/7/21
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Drug Treatment of Heart Failure with Reduced Ejection Fraction: Defining the Role of Vericiguat
AJS Coats, H Tolppanen - Drugs, 2021
Vericiguat, a novel stimulator of soluble guanylate cyclase (sGC), has shown
promising results in patients with heart failure and reduced ejection fraction (HFrEF)
in the recent VICTORIA trial. The nitric oxide (NO)-sGC-cyclic guanosine …
promising results in patients with heart failure and reduced ejection fraction (HFrEF)
in the recent VICTORIA trial. The nitric oxide (NO)-sGC-cyclic guanosine …
| | | |
Ventricular assist devices in paediatric cardiomyopathy and congenital heart disease: An analysis of the German National Register for Congenital Heart Defects
AE Lammers, KS Sprenger, GP Diller, O Miera… - International Journal of …, 2021
Background Ventricular assist devices (VAD) are increasingly used in patients with
end-stage heart failure due to acquired heart disease. Limited data exists on the use
and outcome of this technology in children. Methods All children (< 18 years of age) …
end-stage heart failure due to acquired heart disease. Limited data exists on the use
and outcome of this technology in children. Methods All children (< 18 years of age) …
| | | |
Phenotyping Heart Failure Patients for Iron Deficiency and Use of Intravenous Iron Therapy: Data from the Swedish Heart Failure Registry
PM Becher, B Schrage, L Benson, M Fudim… - European journal of heart failure
Aims Iron deficiency (ID) is associated with poor prognosis regardless of anemia.
Intravenous iron improves quality of life and outcomes in patients with ID and heart
failure (HF) with reduced ejection fraction (HFrEF). In the Swedish HF registry, we …
Intravenous iron improves quality of life and outcomes in patients with ID and heart
failure (HF) with reduced ejection fraction (HFrEF). In the Swedish HF registry, we …
| | | |
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Okechukwu Ogah
Sep 9, 2021, 12:40:08 PM9/9/21
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Clinical significance of the N-terminal pro-brain natriuretic peptide and B-type natriuretic peptide ratio in the acute phase of acute heart failure
T Sawatani, A Shirakabe, H Okazaki, M Matsushita… - European Heart Journal …, 2021
Aims Serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and B-type
natriuretic peptide (BNP) levels are rarely evaluated simultaneously in the acute
phase of acute heart failure (AHF). Method and results A total of 1207 AHF patients …
natriuretic peptide (BNP) levels are rarely evaluated simultaneously in the acute
phase of acute heart failure (AHF). Method and results A total of 1207 AHF patients …
Okechukwu Ogah
Sep 12, 2021, 1:19:29 PM9/12/21
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[HTML] Impact of insulin therapy on the mortality of acute heart failure patients with diabetes mellitus
SY Jang, J Jang, DH Yang, HJ Cho, S Lim, ES Jeon… - Cardiovascular Diabetology, 2021
Patients with diabetes mellitus (DM) have a higher prevalence of heart failure (HF)
than those without it. Approximately 40% of HF patients have DM and they tend to
have poorer outcomes than those without DM. This study evaluated the impact of …
than those without it. Approximately 40% of HF patients have DM and they tend to
have poorer outcomes than those without DM. This study evaluated the impact of …
| | | |
Prenatal diagnosis and planned peripartum care improve perinatal outcome of fetuses with transposition of the great arteries and intact ventricular septum in low …
F Kunde, S Thomas, A Sudhakar, R Kunjikutty… - Ultrasound in Obstetrics and …, 2021
Objective To report on the feasibility of establishing a regional prenatal referral
network for critical congenital heart defects (CHDs) and its impact on perinatal
outcome of fetuses with transposition of the great arteries and intact ventricular …
network for critical congenital heart defects (CHDs) and its impact on perinatal
outcome of fetuses with transposition of the great arteries and intact ventricular …
Okechukwu Ogah
Sep 14, 2021, 3:57:14 PM9/14/21
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A Global Perspective of Racial Differences and Outcomes in Patients Presenting with Acute Heart Failure
J Tromp, W Ouwerkerk, JGF Cleland, C Chandramouli… - American Heart Journal, 2021
Important racial differences in characteristics, treatment, and outcomes of patient with
acute heart failure (AHF) have been described. The objective of this analysis of the
International REgistry to assess medical Practice with lOngitudinal obseRvation for …
acute heart failure (AHF) have been described. The objective of this analysis of the
International REgistry to assess medical Practice with lOngitudinal obseRvation for …
| | | |
Physical Rehabilitation in Older Patients Hospitalized with Acute Heart Failure and Diabetes: Insights from REHAB-HF
EM Murray, DJ Whellan, H Chen, AG Bertoni… - The American Journal of …, 2021
Background Prior studies showed an attenuated response to exercise training
among patients with heart failure and type 2 diabetes mellitus. We explored the
interaction between diabetes status and a novel, transitional, tailored, progressive …
among patients with heart failure and type 2 diabetes mellitus. We explored the
interaction between diabetes status and a novel, transitional, tailored, progressive …
| | | |
Non-cardiology vs. cardiology care of patients with heart failure and reduced ejection fraction is associated with lower use of guideline-based care and higher mortality …
CJ Kapelios, M Canepa, L Benson, C Hage… - International Journal of …, 2021
Background Patients with heart failure (HF) are often cared for by non-cardiologists.
The implications are unknown. Methods In a nationwide HF cohort with reduced
ejection fraction (HFrEF), we compared demographics, clinical characteristics …
The implications are unknown. Methods In a nationwide HF cohort with reduced
ejection fraction (HFrEF), we compared demographics, clinical characteristics …
| | | |
Sacubitril/valsartan adherence and postdischarge outcomes among patients hospitalized for heart failure with reduced ejection fraction
AP Carnicelli, Z Li, MA Greiner, SJ Lippmann… - JACC: Heart Failure, 2021
Objectives The authors sought to investigate associations between
sacubitril/valsartan adherence and clinical outcomes after hospitalization for heart
failure with reduced ejection fraction (HFrEF). Background Sacubitril/valsartan …
sacubitril/valsartan adherence and clinical outcomes after hospitalization for heart
failure with reduced ejection fraction (HFrEF). Background Sacubitril/valsartan …
| | | |
[PDF] Myocardial ultrastructure can augment genetic testing for sporadic dilated cardiomyopathy with initial heart failure
T Saito, NS Sato, K Mozawa, A Adachi, Y Sasaki… - ESC Heart Failure, 2021
Aims The aim of the present study was to consider whether the ultrastructural
features of cardiomyocytes in dilated cardiomyopathy can be used to guide genetic
testing. Methods and results Endomyocardial biopsy and whole‐exome sequencing …
features of cardiomyocytes in dilated cardiomyopathy can be used to guide genetic
testing. Methods and results Endomyocardial biopsy and whole‐exome sequencing …
Okechukwu Ogah
Sep 19, 2021, 3:55:39 PM9/19/21
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Arrhythmogenic cardiomyopathy: the ongoing search for mechanism-driven therapies meets extracellular vesicles
C Basso, T Zaglia, K Pilichou - European Heart Journal, 2021
Arrhythmogenic cardiomyopathy (AC) is nowadays a well-recognized inherited heart
muscle disease, mostly due to mutations in genes encoding desmosomal proteins,
predisposing to stress-related life-threatening ventricular arrhythmias, particularly in …
muscle disease, mostly due to mutations in genes encoding desmosomal proteins,
predisposing to stress-related life-threatening ventricular arrhythmias, particularly in …
| | | |
Intravenous iron supplementation: novel anti-remodelling therapy for patients with heart failure?
EA Jankowska, P Ponikowski - European Heart Journal, 2021
Iron deficiency (ID) remains a unique and intriguing comorbidity, not only among
patients with heart failure (HF). It is quite astonishing why ID, being the most common
nutritional disorder worldwide, 1 has been somewhat neglected by haematologists …
patients with heart failure (HF). It is quite astonishing why ID, being the most common
nutritional disorder worldwide, 1 has been somewhat neglected by haematologists …
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[HTML] A combinatorial oligogenic basis for the phenotypic plasticity between late-onset dilated and arrhythmogenic cardiomyopathy in a single family
K Pourebrahim, JG Marian, Y Tan, JT Chang… - The Journal of …, 2021
Introduction: Primary dilated cardiomyopathy (DCM) and arrhythmogenic right
ventricular cardiomyopathy (ARVC) are the two common and distinct forms of
hereditary cardiomyopathies caused by defined pathogenic variants (PVs) typically …
ventricular cardiomyopathy (ARVC) are the two common and distinct forms of
hereditary cardiomyopathies caused by defined pathogenic variants (PVs) typically …
Okechukwu Ogah
Sep 29, 2021, 11:17:38 AM9/29/21
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Accomplice or bystander? The role of COVID-19 in a case of peripartum cardiomyopathy
M Mapelli, E Conte, A Lissoni, B Nusca, M Dessanai… - European Heart Journal …, 2021
Background: Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy with
systolic dysfunction that presents in late pregnancy. A number of coronavirus disease
19 (COVID-19)-related myocarditis cases have been reported. In a pandemic …
systolic dysfunction that presents in late pregnancy. A number of coronavirus disease
19 (COVID-19)-related myocarditis cases have been reported. In a pandemic …
Okechukwu Ogah
Oct 1, 2021, 6:54:15 PM10/1/21
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Development of heart failure with preserved ejection fraction in type 2 diabetic mice is ameliorated by preserving vascular function
M Otto, L Brabenec, M Müller, S Kintrup… - Life Sciences, 2021
Aims Heart failure with preserved ejection fraction (HFpEF) is associated with
endothelial dysfunction and is frequent in people with type 2 diabetes mellitus. In
diabetic patients, increased levels of the eicosanoid 12-hydroxyeicosatetraenoic acid …
endothelial dysfunction and is frequent in people with type 2 diabetes mellitus. In
diabetic patients, increased levels of the eicosanoid 12-hydroxyeicosatetraenoic acid …
| | | |
Early Diastolic Longitudinal Strain Rate at MRI and Outcomes in Heart Failure with Preserved Ejection Fraction
J He, W Yang, W Wu, S Li, G Yin, B Zhuang, J Xu… - Radiology, 2021
Background Assessment of subclinical myocardial dysfunction by using feature
tracking has shown promise in prognosis evaluation of heart failure with preserved
ejection fraction (HFpEF). Global early diastolic longitudinal strain rate (eGLSR) can …
tracking has shown promise in prognosis evaluation of heart failure with preserved
ejection fraction (HFpEF). Global early diastolic longitudinal strain rate (eGLSR) can …
| | | |
Noncontrast Cardiac Magnetic Resonance Imaging Predictors of Heart Failure Hospitalization in Heart Failure With Preserved Ejection Fraction
S Kucukseymen, A Arafati, T Al‐Otaibi, H El‐Rewaidy… - Journal of Magnetic …, 2021
Background Heart failure patients with preserved ejection fraction (HFpEF) are at
increased risk of future hospitalization. Contrast agents are often contra‐indicated in
HFpEF patients due to the high prevalence of concomitant kidney disease …
increased risk of future hospitalization. Contrast agents are often contra‐indicated in
HFpEF patients due to the high prevalence of concomitant kidney disease …
| | | |
Exercise training for prevention and treatment of older adults with heart failure with preserved ejection fraction
A Amjad, PH Brubaker, B Upadhya - Experimental Gerontology, 2021
Heart failure (HF) with preserved ejection fraction (HFpEF) is the most rapidly
increasing form of HF, occurs primarily in older women, and is associated with high
rates of morbidity, mortality, and health care expenditures. In the highest age decile …
increasing form of HF, occurs primarily in older women, and is associated with high
rates of morbidity, mortality, and health care expenditures. In the highest age decile …
| | | |
One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection …
M Hieda, S Sarma, CM Hearon Jr, JP MacNamara… - Circulation, 2021
Background: Individuals with left ventricular (LV) hypertrophy and elevated cardiac
biomarkers in middle age are at increased risk for the development of heart failure
with preserved ejection fraction. Prolonged exercise training reverses the LV …
biomarkers in middle age are at increased risk for the development of heart failure
with preserved ejection fraction. Prolonged exercise training reverses the LV …
| | | |
Improvement in Kansas City Cardiomyopathy Questionnaire Scores After a Self-Care Intervention in Patients With Acute Heart Failure Discharged From the …
WB Stubblefield, CA Jenkins, D Liu, AB Storrow… - … : Cardiovascular Quality and …, 2021
Background: We conducted a secondary analysis of changes in the Kansas City
Cardiomyopathy Questionnaire (KCCQ)-12 over 30 days in a randomized trial of self-
care coaching versus structured usual care in patients with acute heart failure who …
Cardiomyopathy Questionnaire (KCCQ)-12 over 30 days in a randomized trial of self-
care coaching versus structured usual care in patients with acute heart failure who …
| | | |
EM Murray, DJ Whellan, H Chen, AG Bertoni… - The American journal of …, 2021
Background Prior studies showed an attenuated response to exercise training
among patients with heart failure and type 2 diabetes mellitus. We explored the
interaction between diabetes status and a novel, transitional, tailored, progressive …
among patients with heart failure and type 2 diabetes mellitus. We explored the
interaction between diabetes status and a novel, transitional, tailored, progressive …
| | | |
[HTML] Evaluation of Adherence to Guideline for Heart Failure with Reduced Ejection Fraction in Heart Failure with Preserved Ejection Fraction and with or without Atrial …
MS Ahn, BS Yoo, JW Son, YJ Park, HY Lee, ES Jeon… - Journal of Korean Medical …, 2021
Background This study evaluated the relationship between guideline adherence for
heart failure (HF) with reduced ejection fraction (HFrEF) at discharge and relevant
clinical outcomes in patients with acute HF with preserved ejection fraction (HFpEF) …
heart failure (HF) with reduced ejection fraction (HFrEF) at discharge and relevant
clinical outcomes in patients with acute HF with preserved ejection fraction (HFpEF) …
| | | |
Prior Authorization, Copayments, and Utilization of Sacubitril/Valsartan in Medicare and Commercial Plans in Patients With Heart Failure With Reduced Ejection …
AF Ozaki, HM Krumholz, FV Mody, TT Tran, QT Le… - … : Cardiovascular Quality and …, 2021
Background: Slow uptake of sacubitril/valsartan in patients with heart failure with
reduced ejection fraction has been reported, which may negatively impact clinical
outcomes. We characterized prior authorization (PA) burden, prescription …
reduced ejection fraction has been reported, which may negatively impact clinical
outcomes. We characterized prior authorization (PA) burden, prescription …
| | | |
Prognostic significance of longitudinal strain in dilated cardiomyopathy with recovered ejection fraction
M Merlo, M Masè, A Perry, E La Franca, E Deych… - Heart, 2021
Objective Patients with non-ischaemic dilated cardiomyopathy (NICM) may
experience a normalisation in left ventricular ejection fraction (LVEF). Although this
correlates with improved prognosis, it does not correspond to a normalisation in the …
experience a normalisation in left ventricular ejection fraction (LVEF). Although this
correlates with improved prognosis, it does not correspond to a normalisation in the …
| | | |
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Okechukwu Ogah
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Pharmacologic Weight Loss for Heart Failure With Preserved Ejection Fraction: Getting to the Core of the Problem
DN Silverman, SE Litwin - Circulation: Heart Failure, 2021
Obesity has a strong and graded association with incident heart failure (HF). 1 The
association is much stronger for HF with preserved ejection fraction (HFpEF) than for
HF with reduced ejection fraction. 2 The rising proportion of HFpEF is likely fueled by …
association is much stronger for HF with preserved ejection fraction (HFpEF) than for
HF with reduced ejection fraction. 2 The rising proportion of HFpEF is likely fueled by …
| | | |
Heart Failure with Preserved Ejection Fraction after Left‐sided Valve Surgery: Prevalent and Relevant
AA Kammerlander, C Nitsche, C Donà, M Koschutnik… - European Journal of Heart …, 2021
Aims To investigate the epidemiological and prognostic relationship between heart
failure and preserved ejection fraction (HFpEF) and left‐sided valve surgery using all‐
cause mortality as a primary endpoint. Methods and Results We studied a total of …
failure and preserved ejection fraction (HFpEF) and left‐sided valve surgery using all‐
cause mortality as a primary endpoint. Methods and Results We studied a total of …
| | | |
[PDF] Right ventricular and cyclic guanosine monophosphate signalling abnormalities in stages B and C of heart failure with preserved ejection fraction
T Petit, G Claessen, M Claeys, A La Gerche, P Claus… - ESC Heart Failure, 2021
Aims Identifying early right ventricular (RV) dysfunction and impaired vasodilator
reserve is challenging in heart failure with preserved ejection fraction (HFpEF). We
hypothesized that cardiac magnetic resonance (CMR)‐based exercise imaging and …
reserve is challenging in heart failure with preserved ejection fraction (HFpEF). We
hypothesized that cardiac magnetic resonance (CMR)‐based exercise imaging and …
| | | |
[HTML] Real-world safety of sacubitril/valsartan in women and men with heart failure and reduced ejection fraction: A meta-analysis
K Nuechterlein, A AlTurki, J Ni, M Martínez-Sellés… - 2021
Structured Abstract Background Sacubitril/valsartan (SV) is a novel and effective
therapy for heart failure with reduced ejection fraction (HFrEF). Despite several sex-
specific particularities that may influence drug effects, there has been no prior study …
therapy for heart failure with reduced ejection fraction (HFrEF). Despite several sex-
specific particularities that may influence drug effects, there has been no prior study …
| | | |
[PDF] Pregnancy, a unique case of heterochronic parabiosis and peripartum cardiomyopathy
PJ Goldschmidt-Clermont, C Hubinont… - 2021
Introduction: parabiosis, placenta, amniotic small extracellular vesicles and
pregnancy 3. Key roles of amniotic extracellular vesicles in pregnancy 4. Mechanism
for amniotic extracellular vesicles fusion with target cells: Pierre-Simon Laplace 5 …
pregnancy 3. Key roles of amniotic extracellular vesicles in pregnancy 4. Mechanism
for amniotic extracellular vesicles fusion with target cells: Pierre-Simon Laplace 5 …
Okechukwu Ogah
Oct 5, 2021, 6:04:10 PM10/5/21
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Exercise training for prevention and treatment of older adults with heart failure with preserved ejection fraction
A Amjad, PH Brubaker, B Upadhya - Experimental Gerontology, 2021
Heart failure (HF) with preserved ejection fraction (HFpEF) is the most rapidly
increasing form of HF, occurs primarily in older women, and is associated with high
rates of morbidity, mortality, and health care expenditures. In the highest age decile …
increasing form of HF, occurs primarily in older women, and is associated with high
rates of morbidity, mortality, and health care expenditures. In the highest age decile …
| | | |
miR-181c level predicts response to exercise training in patients with heart failure and preserved ejection fraction: an analysis of the OptimEx-Clin trial
AB Gevaert, I Witvrouwen, AH Van Craenenbroeck… - European Journal of …, 2021
Aims In patients with heart failure with preserved ejection fraction (HFpEF), exercise
training improves the quality of life and aerobic capacity (peak V· O2). Up to 55% of
HF patients, however, show no increase in peak V· O2 despite adequate training. We …
training improves the quality of life and aerobic capacity (peak V· O2). Up to 55% of
HF patients, however, show no increase in peak V· O2 despite adequate training. We …
| | | |
Subclinical myocardial injury and the phenotype of clinical congestion in patients with heart failure and reduced left ventrcular ejection fraction
JT Thibodeau, DD Pham, SA Kelly, CR Ayers, S Garg… - Journal of Cardiac Failure, 2021
Background Clinical congestion is associated with adverse outcomes in patients with
heart failure. The pathophysiological mediators of this association remain uncertain.
Methods We prospectively enrolled a cohort of patients with heart failure and …
heart failure. The pathophysiological mediators of this association remain uncertain.
Methods We prospectively enrolled a cohort of patients with heart failure and …
| | | |
Clinical usefulness of left ventricular outflow tract velocity time integral for heart failure with reduced ejection fraction with rapid atrial fibrillation during landiolol …
N Iwahashi, J Kirigaya, T Abe, M Horii, H Takahashi… - Journal of Cardiology, 2021
Background Landiolol enables us to treat the patients with rapid atrial fibrillation (AF)
with acute decompensated heart failure (ADHF) efficiently. We sought to determine
the role of echocardiography in predicting the prognosis. Methods Among 314 …
with acute decompensated heart failure (ADHF) efficiently. We sought to determine
the role of echocardiography in predicting the prognosis. Methods Among 314 …
| | | |
[HTML] Generalisability of Randomised Controlled Trials in Heart Failure with Reduced Ejection Fraction
YMF Lim, M Molnar, I Vaartjes, G Savarese… - European Heart Journal …, 2021
Background Heart failure (HF) trials have stringent in-and ex-clusion criteria, but
limited data exists regarding generalisability of trials. We compared patient
characteristics and outcomes between patients with HF and reduced ejection fraction …
limited data exists regarding generalisability of trials. We compared patient
characteristics and outcomes between patients with HF and reduced ejection fraction …
| | | |
[PDF] Patterns of Use and Clinical Outcomes with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Acute Heart Failure and Changes in …
RO Mathew, KB Lo, P Tipparaju, E Phelps, MS Sidhu… - Cardiorenal Medicine
Objective: The aim of the study was to determine patterns and predictors of utilization
of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers
(ACEI/ARBs) in patients with acute heart failure (AHF) and changes in kidney …
of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers
(ACEI/ARBs) in patients with acute heart failure (AHF) and changes in kidney …
| | | |
[PDF] Heart failure treatment according to the 2021 European Society of Cardiology Guidelines—experiences with SGLT2 inhibitors have changed the treatment strategy
J Kubica - Medical Research Journal, 2021
Previously the treatment with b-blockers, angiotensin-converting enzyme inhibitors or
angiotensin receptor blockers and mineralocorticoid receptor antagonists, was
shown to provide benefits in terms of mortality and morbidity in heart failure (HF) …
angiotensin receptor blockers and mineralocorticoid receptor antagonists, was
shown to provide benefits in terms of mortality and morbidity in heart failure (HF) …
| | | |
Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype
S Fitzsimons, TJ Yeo, LH Ling, D Sim, KTG Leong… - ESC heart failure
Aims The importance of iron deficiency (ID) in heart failure with preserved ejection
fraction (HFpEF) is unknown. In HF with reduced ejection fraction (HFrEF), ID is
reported as an independent predictor of mortality in HF although not all published …
fraction (HFpEF) is unknown. In HF with reduced ejection fraction (HFrEF), ID is
reported as an independent predictor of mortality in HF although not all published …
| | | |
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Okechukwu Ogah
Oct 10, 2021, 1:33:50 PM10/10/21
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A randomized clinical trial on the short‐term effects of 12 weeks sacubitril/valsartan versus enalapril on peak oxygen consumption in patients with heart failure with …
M Halle, C Schöbel, EB Winzer, P Bernhardt, S Mueller… - European Journal of Heart …, 2021
Aims ACTIVITY‐HF was a randomized, double‐blind, active‐controlled study, which
assessed the short‐term effect of sacubitril/valsartan compared with the active‐
comparator enalapril on improving maximal exercise capacity in patients with heart …
assessed the short‐term effect of sacubitril/valsartan compared with the active‐
comparator enalapril on improving maximal exercise capacity in patients with heart …
| | | |
Association of Early Blood Pressure Decrease and Renal Function With Prognosis in Acute Heart Failure
Y Matsue, IE Sama, D Postmus, M Metra… - JACC: Heart Failure, 2021
Objectives The aim of this study was to investigate the association between systolic
blood pressure (SBP) drop, worsening renal function (WRF), and prognosis in
patients with acute heart failure (AHF). Background A large drop in SBP early after …
blood pressure (SBP) drop, worsening renal function (WRF), and prognosis in
patients with acute heart failure (AHF). Background A large drop in SBP early after …
| | | |
[HTML] Growth differentiation factor 15 predicts poor prognosis in patients with heart failure and reduced ejection fraction and anemia: results from RED-HF
T Ueland, L Gullestad, L Kou, JB Young, MA Pfeffer… - Clinical Research in …, 2021
Aims We aimed to assess the value of GDF-15, a stress-responsive cytokine, in
predicting clinical outcomes in patients with heart failure (HF) with reduced ejection
fraction (HFrEF) and anemia Methods and results Serum GDF-15 was assessed in …
predicting clinical outcomes in patients with heart failure (HF) with reduced ejection
fraction (HFrEF) and anemia Methods and results Serum GDF-15 was assessed in …
| | | |
[PDF] Bromocriptine as a Novel Therapeutic Agent for Peripartum Cardiomyopathy (PPCM): Pathophysiological Basis, Recent Progress and Future Prospect
ABM Nasibul Alam, NP Ballestas, T Blazin, D Prajapati… - J Comm Med and Pub …, 2021
In the late antepartum and the early postpartum period, peripartum cardiomyopathy
(PPCM) is an important etiology of heart failure. A disease of increasing severity,
PPCM has substantial heterogeneity in its regional and ethnic distribution. Besides …
(PPCM) is an important etiology of heart failure. A disease of increasing severity,
PPCM has substantial heterogeneity in its regional and ethnic distribution. Besides …
| | | |
[HTML] Peripartum Cardiomyopathy. Medical Support Strategy
SO Siromakha, IV Davydova, LO Nevmerzhytska… - Ukrainian Journal of …, 2021
Peripartum cardiomyopathy (PPCM) is an idiopathic myocardial insufficiency that
occurs in the absence of any diagnosed heart disease during the last month of
pregnancy or during the first 5 months after delivery. The aim. To improve immediate …
occurs in the absence of any diagnosed heart disease during the last month of
pregnancy or during the first 5 months after delivery. The aim. To improve immediate …
Okechukwu Ogah
Oct 12, 2021, 5:47:45 PM10/12/21
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[PDF] Prognostic Importance of Pulmonary Arterial Capacitance in Acute Decompensated Heart Failure With Preserved Ejection Fraction
A Nakagawa, Y Yasumura, C Yoshida, T Okumura… - Journal of the American …, 2021
Background Although the prognostic importance of pulmonary arterial capacitance
(PAC; stroke volume/pulmonary arterial pulse pressure) has been elucidated in heart
failure with reduced ejection fraction, whether its significance in patients suffering …
(PAC; stroke volume/pulmonary arterial pulse pressure) has been elucidated in heart
failure with reduced ejection fraction, whether its significance in patients suffering …
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[HTML] Cost Effectiveness of Vericiguat for the Treatment of Chronic Heart Failure with Reduced Ejection Fraction Following a Worsening Heart Failure Event from a US …
A Alsumali, LM Djatche, A Briggs, R Liu, I Diakite… - PharmacoEconomics, 2021
Objective Given the high economic burden of disease among adult patients with
chronic heart failure with reduced ejection fraction (HFrEF) following a worsening
heart failure event in the US, this study aimed to estimate the cost effectiveness of …
chronic heart failure with reduced ejection fraction (HFrEF) following a worsening
heart failure event in the US, this study aimed to estimate the cost effectiveness of …
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[HTML] Clinical outcomes of Sacubitril/Valsartan in patients with acute heart failure: A multi-institution study
DY Chen, CC Chen, CN Tseng, SW Chen, SH Chang… - EClinicalMedicine, 2021
Background The effectiveness and safety of initiating sacubitril/valsartan therapy
among patients who are hospitalized for acute heart failure (HF) is unclear. Methods
A cohort of 3736 patients with HF with reduced ejection fraction (HFrEF) hospitalized …
among patients who are hospitalized for acute heart failure (HF) is unclear. Methods
A cohort of 3736 patients with HF with reduced ejection fraction (HFrEF) hospitalized …
| | | |
Risk Adjustment Model for Preserved Health Status in Patients With Heart Failure and Reduced Ejection Fraction: The CHAMP-HF Registry
AT Tran, GC Fonarow, SV Arnold, PG Jones… - … : Cardiovascular Quality and …, 2021
Background: Health status outcomes are increasingly being promoted as measures
of health care quality, given their importance to patients. In heart failure (HF), an
American College of Cardiology/American Heart Association Task Force proposed …
of health care quality, given their importance to patients. In heart failure (HF), an
American College of Cardiology/American Heart Association Task Force proposed …
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[HTML] Beta-blockers are associated with reverse remodeling in patients with dilated cardiomyopathy and mid-range ejection fraction
N Enzan, S Matsushima, T Ide, T Tohyama… - American Heart Journal …, 2021
Background Beta-blockers have been shown to induce left ventricular reverse
remodeling (LVRR) in heart failure with reduced ejection fraction. This study aimed to
determine whether beta-blockers could induce LVRR in patients with heart failure …
remodeling (LVRR) in heart failure with reduced ejection fraction. This study aimed to
determine whether beta-blockers could induce LVRR in patients with heart failure …
| | | |
[PDF] 43 Sacubitril/Valsartan results in a significant reduction in the need for prophylactic impantable cardiac defibrillator in a heart failure with reduced ejection fraction …
A O'Brien, A Brennan, A Moore, C Halley, M Barrett… - 2021
Introduction Secubitril/Valsartan (SV) has become a standard front line therapy for
patients with heart failure with reduced ejection fraction (HFrEF) with a left ventricular
ejection fraction (LVEF) less than or equal to 35%. It has been shown to reduce heart …
patients with heart failure with reduced ejection fraction (HFrEF) with a left ventricular
ejection fraction (LVEF) less than or equal to 35%. It has been shown to reduce heart …
| | | |
The ESC Guidelines on heart failure, sacubitril–valsartan in resistant hypertension, and new therapeutic targets in myocardial hypertrophy
F Crea - 2021
This Focus Issue on heart failure and cardiomyopathies contains the '2021 ESC
Guidelines for the diagnosis and treatment of acute and chronic heart failure'. 1
These Guidelines are extremely innovative. They introduce new concepts compared …
Guidelines for the diagnosis and treatment of acute and chronic heart failure'. 1
These Guidelines are extremely innovative. They introduce new concepts compared …
| | | |
[PDF] Circulating miR‐19b‐3p as a Novel Prognostic Biomarker for Acute Heart Failure
Y Su, Y Sun, Y Tang, H Li, X Wang, X Pan, W Liu… - Journal of the American …, 2021
Background Circulating microRNAs are emerging biomarkers for heart failure (HF).
Our study aimed to assess the prognostic value of microRNA signature that is
differentially expressed in patients with acute HF. Methods and Results Our study …
Our study aimed to assess the prognostic value of microRNA signature that is
differentially expressed in patients with acute HF. Methods and Results Our study …
| | | |
Wild type transthyretin cardiac amiloidozis as a rare and overlooked underlying etiology in a patient with heart failure with preserved ejection fraction and left …
S Murat, Y Çavuşoğlu, İA Sivrikoz - Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji …, 2021
Cardiac amyloidosis (CA) is a rare, progressive, infiltrative and restrictive
cardiomyopathy characterized by extracellular deposition of insoluble amyloid fibrils
in the form of misfolded endogenous proteins in the heart. The most common types of …
cardiomyopathy characterized by extracellular deposition of insoluble amyloid fibrils
in the form of misfolded endogenous proteins in the heart. The most common types of …
| | | |
[PDF] Peripartum cardiomyopathy incidence and mortality in Sweden
G Mattsson, P Magnusson - Cardiology Journal, 2021
Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy with
reduced ejection fraction that affects women late in pregnancy or the months
following delivery [1]. It is a global disease with various geographical incidence and …
reduced ejection fraction that affects women late in pregnancy or the months
following delivery [1]. It is a global disease with various geographical incidence and …
Okechukwu Ogah
Oct 15, 2021, 1:45:58 PM10/15/21
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[PDF] Comprehensive Physiological Modeling Provides Novel Insights Into Heart Failure With Preserved Ejection Fraction Physiology
DM Kaye, E Wolsk, S Nanayakkara, J Mariani… - Journal of the American …, 2021
Background Although a rapid rise in left atrial pressure during exertion is considered
pathognomonic of heart failure with preserved ejection fraction (HFpEF), the
fundamental circulatory determinants of this response are not clear, impacting upon …
pathognomonic of heart failure with preserved ejection fraction (HFpEF), the
fundamental circulatory determinants of this response are not clear, impacting upon …
| | | |
Artificial Intelligence‐Enhanced ECG Identification of Low Ejection Fraction: A Pragmatic, Cluster‐Randomized Clinical Trial
X Yao, D Rushlow, J Inselman, R McCoy, T Thacher… - Health Services Research, 2021
Research Objective An artificial intelligence (AI) algorithm based on ECG was
integrated into clinical workflows to identify patients with a high likelihood of low
ejection (EF), a condition that is underdiagnosed but treatable. The trial aimed to …
integrated into clinical workflows to identify patients with a high likelihood of low
ejection (EF), a condition that is underdiagnosed but treatable. The trial aimed to …
| | | |
[HTML] Cost-Utility Analysis of Sacubitril-Valsartan Compared with Enalapril Treatment in Patients with Acute Decompensated Heart Failure in Thailand
R Krittayaphong, U Permsuwan - Clinical Drug Investigation, 2021
Background Sacubitril-valsartan is effective in reducing the N-terminal pro-B-type
natriuretic peptide level of hospitalized patients with acute decompensated heart
failure, with a high acquisition cost compared with enalapril treatment. Objective This …
natriuretic peptide level of hospitalized patients with acute decompensated heart
failure, with a high acquisition cost compared with enalapril treatment. Objective This …
| | | |
Early and short‐term intensive management after discharge for patients hospitalized with acute heart failure, a randomized study (ECAD‐HF)
D Logeart, E Berthelot, N Bihry, R Eschalier, M Salvat… - European Journal of Heart Failure
Aims Hospitalization for acute heart failure (HF) is followed by a vulnerable time with
increased risk of readmission or death, thus requiring particular attention after
discharge. In this study we examined the impact of intensive, early follow‐up among …
increased risk of readmission or death, thus requiring particular attention after
discharge. In this study we examined the impact of intensive, early follow‐up among …
| | | |
[PDF] Prognostic value of left atrial strain in patients with wild‐type transthyretin amyloid cardiomyopathy
F Oike, H Usuku, E Yamamoto, T Yamada, K Egashira… - ESC Heart Failure, 2021
Aims This study was performed to investigate whether left atrial (LA) strain by
echocardiography provides prognostic information in patients with wild‐type
transthyretin amyloid cardiomyopathy (ATTRwt‐CM). Methods and results Among …
echocardiography provides prognostic information in patients with wild‐type
transthyretin amyloid cardiomyopathy (ATTRwt‐CM). Methods and results Among …
| | | |
[PDF] Prevalence and prognostic implications of diabetes with cardiomyopathy in community-dwelling adults
MW Segar, MS Khan, KV Patel, J Butler, WHW Tang… - Journal of the American …, 2021
Background Diabetes is associated with abnormalities in cardiac remodeling and
high risk of heart failure (HF). Objectives The purpose of this study was to evaluate
the prevalence and prognostic implications of diabetes with cardiomyopathy (DbCM) …
high risk of heart failure (HF). Objectives The purpose of this study was to evaluate
the prevalence and prognostic implications of diabetes with cardiomyopathy (DbCM) …
| | | |
[HTML] Hypertensive Heart Failure in Asia
H Rismiati, HY Lee - Pulse
Hypertension (HT) is an important risk factor for heart failure (HF). The prevalence of
HT among the HF population is higher in Asia than in other regions around the world.
In Asia, HT is the most common cause of HF after ischemic heart disease …
HT among the HF population is higher in Asia than in other regions around the world.
In Asia, HT is the most common cause of HF after ischemic heart disease …
Okechukwu Ogah
Oct 21, 2021, 2:40:46 PM10/21/21
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Sodium-glucose co-transporter-2 inhibitors improve cardiovascular outcomes in heart failure with reduced ejection fraction regardless of ischemic etiology
D Patoulias, A Boulmpou, C Tsavousoglou… - European Heart Journal, 2021
Background Coronary artery disease remains the main underlying cause of heart
failure (HF), despite the progress in prevention, diagnosis and treatment. Sodium-
glucose co-transporter-2 inhibitors have been shown to improve surrogate …
failure (HF), despite the progress in prevention, diagnosis and treatment. Sodium-
glucose co-transporter-2 inhibitors have been shown to improve surrogate …
| | | |
[PDF] Sacubitril-valsartan in Heart Failure With Preserved Ejection Fraction Following Acute Coronary Syndrome
Z Han, C Wang, J Zhang, J Gu - 2021
Background It was indicated that sacubitril-valsartan could improve the clinical
prognosis in speci c phenotype of heart failure with preserved ejection fraction
(HFpEF) patients compared with valsartan. However, there is lack of evidence of the …
prognosis in speci c phenotype of heart failure with preserved ejection fraction
(HFpEF) patients compared with valsartan. However, there is lack of evidence of the …
| | | |
RO Mathew, KB Lo, P Tipparaju, E Phelps, MS Sidhu… - Cardiorenal Medicine, 2021
Objective: The aim of the study was to determine patterns and predictors of utilization
of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers
(ACEI/ARBs) in patients with acute heart failure (AHF) and changes in kidney …
of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers
(ACEI/ARBs) in patients with acute heart failure (AHF) and changes in kidney …
| | | |
[HTML] Sacubitril/valsartan is well tolerated in patients with longstanding heart failure and history of cancer and improves ventricular function: real-world data
MK Frey, H Arfsten, N Pavo, E Han, S Kastl… - Cardio-Oncology, 2021
Sacubitril/valsartan has been shown to significantly reduce cardiovascular mortality
and hospitalizations due to heart failure in patients with reduced ejection fraction
(HFrEF) when compared to enalapril. Data about sacubitril/valsartan in patients with …
and hospitalizations due to heart failure in patients with reduced ejection fraction
(HFrEF) when compared to enalapril. Data about sacubitril/valsartan in patients with …
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[HTML] Community-based prevalence of rheumatic heart disease in rural Ethiopia: Five-year follow-up
T Gemechu, EHO Parry, MH Yacoub, DIW Phillips… - PLOS Neglected Tropical …, 2021
Background As little is known about the prevalence and clinical progression of
subclinical (latent) rheumatic heart disease (RHD) in sub-Saharan Africa, we report
the results of a 5 year follow-up of a community based, echocardiographic study of …
subclinical (latent) rheumatic heart disease (RHD) in sub-Saharan Africa, we report
the results of a 5 year follow-up of a community based, echocardiographic study of …
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Relationship between peripartum maternal cardiac phenotype and maternal outcome in women with hypertensive disorders of pregnancy
V Giorgione, J O'Driscoll, C Di Fabrizio, A Frick… - European Heart Journal, 2021
Background Hypertensive disorders of pregnancy (HDP) are a leading cause of
maternal and neonatal morbidity worldwide. Purpose The aim of this study is to
assess maternal cardiac function in women affected by HDP in singleton pregnancy …
maternal and neonatal morbidity worldwide. Purpose The aim of this study is to
assess maternal cardiac function in women affected by HDP in singleton pregnancy …
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[PDF] Prognostic impact of systolic blood pressure in acute heart failure with preserved ejection fraction in older patients
S Putot, A Hacquin, P Manckoundia, A Putot - ESC Heart Failure, 2021
Aims Recent guidelines recommend a systolic blood pressure (SBP) target below
130 mmHg in heart failure patients with preserved ejection fraction (HFpEF),
whatever their age. We investigated whether this intensive SBP control was …
130 mmHg in heart failure patients with preserved ejection fraction (HFpEF),
whatever their age. We investigated whether this intensive SBP control was …
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[HTML] Arginine metabolism and nitric oxide turnover in the ZSF1 animal model for heart failure with preserved ejection fraction
P Büttner, S Werner, S Baskal, D Tsikas, V Adams… - Scientific Reports, 2021
Endothelial dysfunction and altered nitric oxide (NO) metabolism are considered
causal factors in heart failure with preserved ejection fraction (HFpEF). NO synthase
activity depends on the availability of arginine and its derivatives. Thus, we analyzed …
causal factors in heart failure with preserved ejection fraction (HFpEF). NO synthase
activity depends on the availability of arginine and its derivatives. Thus, we analyzed …
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Stroke volume but not ejection fraction predicts prognosis in acute heart failure
M Barki, M Losito, MM Caracciolo, F Bandera… - European Heart Journal, 2021
Background Heart failure (HF) patients are categorized according to left ventricular
ejection fraction (LVEF), being such index both easily feasible and prognostic.
However, the risk stratification of patients hospitalized for acute decompensated …
ejection fraction (LVEF), being such index both easily feasible and prognostic.
However, the risk stratification of patients hospitalized for acute decompensated …
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Timing of ejection fraction reassessment after sacubitril-valsartan initiation for indication to defibrillator implantation. A single center experience
V Carinci, E Leci, G Bugani, C Greco, C D'Angelo… - European Heart Journal, 2021
Abstract Background Sacubitril/Valsartan (SV) has recently been validated in the
therapy of heart failure (HF) with reduced ejection fraction (EF). SV is effective on
symptoms and heart remodeling. At the moment the best timing to EF assessment …
therapy of heart failure (HF) with reduced ejection fraction (EF). SV is effective on
symptoms and heart remodeling. At the moment the best timing to EF assessment …
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Efficacy of intravenous ferric carboxymaltose in patients with acute heart failure and iron deficiency with and without anaemia: a subgroup analysis of AFFIRM-AHF
G Filippatos, P Ponikowski, D Farmakis, M Metra… - European Heart Journal, 2021
Background Iron deficiency is associated with increased morbidity and mortality in
patients with acute heart failure (HF), even in the absence of anaemia. Purpose This
prespecified subanalysis of the AFFIRM-AHF trial investigated the effects of ferric …
patients with acute heart failure (HF), even in the absence of anaemia. Purpose This
prespecified subanalysis of the AFFIRM-AHF trial investigated the effects of ferric …
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Sleep-disordered breathing patterns in hospitalized patients with acute heart failure across the entire spectrum of ejection fraction
S Maltês, GJL Cunha, BML Rocha, R Guerreiro… - Sleep and Breathing, 2021
Background Sleep-disordered breathing (SDB) is prevalent in heart failure (HF). Yet,
scarce data exist on sleep-patterns in acute HF and differences in specific
subgroups. Our goal was to assess SDB prevalence in hospitalized patients with …
scarce data exist on sleep-patterns in acute HF and differences in specific
subgroups. Our goal was to assess SDB prevalence in hospitalized patients with …
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Predictors of one year all-cause death in acute heart failure patients enrolled in the nationwide BLITZ-HF study
F Orso, A Di Lenarda, F Oliva, N Aspromonte… - European Heart Journal, 2021
Background Outcomes of patients admitted for acute heart failure (AHF) are
generally poor, then it is important to recognize outcome predictors in order to better
identify and manage patients at higher risk. Aims To identify independent predictors …
generally poor, then it is important to recognize outcome predictors in order to better
identify and manage patients at higher risk. Aims To identify independent predictors …
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Clinical characteristics, management and outcomes in patients with new onset or worsening acute heart failure enrolled in the nationwide BLITZ-HF study
F Orso, A Di Lenarda, F Oliva, M Anselmi… - European Heart Journal, 2021
Background Real world observational clinical data is important to better characterize
heterogeneous groups of patients, such those with acute heart failure (AHF), in order
to phenotype patients with different prognosis and to generate hypotheses regarding …
heterogeneous groups of patients, such those with acute heart failure (AHF), in order
to phenotype patients with different prognosis and to generate hypotheses regarding …
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Prognostic significance of different congestion evaluation modalities in acute heart failure patients classified according to left ventricular ejection fraction
A Palazzuoli, G Ruocco, L Gargani, S Coiro… - European Heart Journal, 2021
Background Congestion is the main reason for hospital admission in patients with
acute heart failure (AHF). Lung ultrasound (LUS) examination has been proposed as
a simple, accurate, and available tool to assess pulmonary congestion, adding …
acute heart failure (AHF). Lung ultrasound (LUS) examination has been proposed as
a simple, accurate, and available tool to assess pulmonary congestion, adding …
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Starting Neurohormonal Antagonists in Patients with Acute Heart Failure with Mid-Range and Preserved Ejection Fraction
Y Seko, T Kato, T Morimoto, H Yaku, Y Inuzuka… - European Heart Journal, 2021
Background The clinical benefits of neurohormonal antagonist in patients with heart
failure (HF) with mid-range and preserved ejection fraction (HFmrEF and HFpEF)
were uncertain. This study aimed to evaluate the prognostic effect of starting …
failure (HF) with mid-range and preserved ejection fraction (HFmrEF and HFpEF)
were uncertain. This study aimed to evaluate the prognostic effect of starting …
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