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Okechukwu Ogah
Jun 10, 2024, 2:23:33 AM6/10/24
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Date: Sun, 9 Jun 2024, 23:06
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[HTML] Effects of sacubitril-valsartan on remodelling, fibrosis and mitochondria in a murine model of isoproterenol-induced left ventricular dysfunction
G Vergaro, A Del Franco, A Carecci, YFF Chen, A Aimo… - International Journal of …, 2024
Background Sacubitril/valsartan has been demonstrated to promote left ventricular
(LV) reverse remodelling and improve outcomes in patients with heart failure (HF)
with reduced ejection fraction (EF). Its molecular and tissue effects have not been …
(LV) reverse remodelling and improve outcomes in patients with heart failure (HF)
with reduced ejection fraction (EF). Its molecular and tissue effects have not been …
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Okechukwu Ogah
Jun 14, 2024, 1:42:28 PM6/14/24
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Dr O.S Ogah. MBBS, MSc, PhD, MD, FWACP, FACP, FESC, FNCS
A. Senior Lecturer
Cardiology Unit, Department of Medicine,
Faculty of Clinical Sciences
College of Medicine,
University of Ibadan, NIGERIA
B. Honorary Consultant Physician/Cardiologist,
Cardiology Unit,
Department of Medicine
University College Hospital Ibadan, NIGERIA
PERSONAL POSTAL ADDRESS
P.O BOX 14343, UNIVERSITY OF IBADAN POST OFFICE
IBADAN, NIGERIA
C. Bernard Lown Visiting Scholar in Cardiovascular Health
Department of Global Health and Population
Harvard T.H. Chan School of Public Health
Email: oo...@hsph.harvard.edu
D. Adjunct Researcher,
Institute of Advanced Medical Research and Training (IAMRAT)
College of Medicine, University of Ibadan, NIGERIA
E. Affiliate Member,
The Hatter Institute for Cardiovascular Research in Africa (HICRA)
4th Floor Chris Barnard Building
Faculty of Health Sciences
University of Cape Town
Private Bag X3 7935
Observatory, SOUTH AFRICA
Faculty of Health Sciences
University of Cape Town
Private Bag X3 7935
Observatory, SOUTH AFRICA
F. Past President,
Nigerian Cardiac Society
--------------------------------------------------------------------------------------------------------------------------------------------------
"For with thee is the fountain of life: in thy light shall we see light." Psalm 36:9
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[HTML] Estimated pulse wave velocity predicts mortality in patients with heart failure with preserved ejection fraction
R Xue, J Zhang, Z Zhen, W Liang, Y Li, L Zhang… - Hellenic Journal of …, 2024
AIM Estimated pulse wave velocity (ePWV), a newly established arterial stiffness
(AS) parameter, predicts development of cardiovascular disease (CVD) and death in
general population or patients with CVD risk factors. However, whether ePWV is …
(AS) parameter, predicts development of cardiovascular disease (CVD) and death in
general population or patients with CVD risk factors. However, whether ePWV is …
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Comparison of Blood Volume Profiles in Heart Failure With Preserved and Reduced Ejection Fractions: Sex Makes a Difference
WL Miller, DE Grill, BP Mullan - Circulation: Heart Failure, 2024
BACKGROUND: Blood volume (BV) profiles vary markedly in patients with heart
failure (HF), but how HF phenotypes and patient sex impact volume profiles remain
to be explored. The aim of the study was to differentiate BV, plasma volume, and red …
failure (HF), but how HF phenotypes and patient sex impact volume profiles remain
to be explored. The aim of the study was to differentiate BV, plasma volume, and red …
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Circulating beta‐hydroxybutyrate levels in advanced heart failure with reduced ejection fraction: Determinants and prognostic impact
L Monzo, J Kovar, BA Borlaug, J Benes, M Kotrc… - European Journal of Heart …, 2024
Aims Patients with heart failure (HF) display metabolic alterations, including
heightened ketogenesis, resulting in increased beta‐hydroxybutyrate (β‐OHB)
formation. We aimed to investigate the determinants and prognostic impact of …
heightened ketogenesis, resulting in increased beta‐hydroxybutyrate (β‐OHB)
formation. We aimed to investigate the determinants and prognostic impact of …
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[HTML] Comparing CHA2DS2-VA and CHA2DS2-VASc scores for stroke risk stratification in patients with atrial fibrillation: a temporal trends analysis from the retrospective …
K Teppo, GYH Lip, KEJ Airaksinen, O Halminen… - The Lancet Regional Health …, 2024
Background Contemporary data have shown a decrease in the ischaemic stroke risk
associated with female sex in patients with atrial fibrillation (AF). We evaluated
temporal trends in the predictive value of a non-sex CHA 2 DS 2-VASc risk score (ie …
associated with female sex in patients with atrial fibrillation (AF). We evaluated
temporal trends in the predictive value of a non-sex CHA 2 DS 2-VASc risk score (ie …
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Employing Real-World Evidence for the Economic Evaluation of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation in Thailand
R Krittayaphong, U Permsuwan - Applied Health Economics and Health Policy, 2024
Background This study aimed to assess the cost-effectiveness of non-vitamin K
antagonist oral anticoagulants (NOACs) in comparison with warfarin using data from
real practice based on the perspective of the health care system in Thailand …
antagonist oral anticoagulants (NOACs) in comparison with warfarin using data from
real practice based on the perspective of the health care system in Thailand …
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[HTML] Pleiotropic Effects of Direct Oral Anticoagulants in Chronic Heart Failure and Atrial Fibrillation: Machine Learning Analysis
M Mele, A Mele, P Imbrici, F Samarelli, R Purgatorio… - Molecules, 2024
Oral anticoagulant therapy (OAT) for managing atrial fibrillation (AF) encompasses
vitamin K antagonists (VKAs, such as warfarin), which was the mainstay of
anticoagulation therapy before 2010, and direct-acting oral anticoagulants (DOACs …
vitamin K antagonists (VKAs, such as warfarin), which was the mainstay of
anticoagulation therapy before 2010, and direct-acting oral anticoagulants (DOACs …
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[HTML] Assessment of a systematic approach for implementing novel medications in clinical practice: an observational study with dapagliflozin
H Norberg, T Andersson, E Håkansson, KH Ängerud… - European Journal of Clinical …, 2024
Objective To assess a systematic implementation approach for introducing
dapagliflozin to individuals with heart failure and reduced ejection fraction in an
outpatient clinical setting. Methods Retrospective medical record data were …
dapagliflozin to individuals with heart failure and reduced ejection fraction in an
outpatient clinical setting. Methods Retrospective medical record data were …
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[HTML] Sodium-Glucose Cotransporter 2 Inhibitor Improves Neurological Outcomes in Diabetic Patients With Acute Ischemic Stroke
W Yang, JM Kim, M Chung, J Ha, DW Kang, EJ Lee… - Journal of Stroke, 2024
Sodium-Glucose Cotransporter 2 Inhibitor Improves Neurological Outcomes in Diabetic
Patients With Acute Ischemic Stroke - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …
Patients With Acute Ischemic Stroke - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …
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[PDF] Effect of Sacubitril/Valsartan on Cognitive Function in Patients With Heart Failure With Preserved Ejection Fraction: A Prespecified Analysis of PARAGON-HF
P Dewan, L Shen, J Pedro Ferreira, PS Jhund… - Circulation, 2024
BACKGROUND: A hypothetical concern has been raised that sacubitril/valsartan
might cause cognitive impairment because neprilysin is one of several enzymes
degrading amyloid-β peptides in the brain, some of which are neurotoxic and linked …
might cause cognitive impairment because neprilysin is one of several enzymes
degrading amyloid-β peptides in the brain, some of which are neurotoxic and linked …
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Peripartum Management of a Patient with Vascular Ehlers-Danlos and Loeys-Dietz Syndromes Complicated by Aortic and Carotid Dissections
MD Jacob Nieb, J Banayan
Peripartum Management of a Patient with Vascular Ehlers-Danlos and Loeys-Dietz
Syndromes Complicated by Aortic and Carotid Disse Page 1 SOAP 2024 ANNUAL
MEETING Peripartum Management of a Patient with Vascular Ehlers-Danlos and …
Syndromes Complicated by Aortic and Carotid Disse Page 1 SOAP 2024 ANNUAL
MEETING Peripartum Management of a Patient with Vascular Ehlers-Danlos and …
Okechukwu Ogah
Jun 22, 2024, 4:18:06 AM6/22/24
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Treatment with sacubitril/valsartan effectively manages hypertension and ameliorates left ventricular hypertrophy in hemodialysis patients
N Hu, N Lv, Y Chen - Blood Purification, 2024
Methods Hemodialysis patients with stable blood pressure control were enrolled in
the study. Sacubitril/valsartan was prescribed to replace previously used ACEI/ARB
or other antihypertensive drugs. During a 6-month follow-up period, pre-dialysis …
the study. Sacubitril/valsartan was prescribed to replace previously used ACEI/ARB
or other antihypertensive drugs. During a 6-month follow-up period, pre-dialysis …
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Patient Focus: Should you take sacubitril/valsartan if you have heart failure with an ejection fraction> 40% and get low blood pressure? An explanation of" Association …
NS Hendren, JT Thibodeau - Journal of cardiac failure, 2024
Patient Focus: Should you take sacubitril/valsartan if you have heart failure with an
ejection fraction >40% and get low blood pressure? An explanation of "Association of
Sacubitril/Valsartan versus Valsartan with Blood Pressure Changes, and Symptomatic …
ejection fraction >40% and get low blood pressure? An explanation of "Association of
Sacubitril/Valsartan versus Valsartan with Blood Pressure Changes, and Symptomatic …
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[PDF] Balcinrenone plus dapagliflozin in patients with heart failure and chronic kidney disease: Results from the phase 2b MIRACLE trial
CSP Lam, L Køber, K Kuwahara, LH Lund, PB Mark… - European Journal of Heart …, 2024
Aims Many patients with heart failure (HF) have chronic kidney disease (CKD) and
may not tolerate mineralocorticoid receptor antagonists. We investigated the efficacy
and safety of the novel mineralocorticoid receptor modulator balcinrenone in …
may not tolerate mineralocorticoid receptor antagonists. We investigated the efficacy
and safety of the novel mineralocorticoid receptor modulator balcinrenone in …
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[PDF] The acute effects of furosemide in acute heart failure assessed by remote dielectric sensing. A protocol
NO El Caidi, JD Lukoschewitz, OW Nielsen, J Hove…
ABSTRACT INTRODUCTION. INTRODUCTION. Intravenous loop diuretics have
been a key component in treating pulmonary oedema since the 1960s and have a
Class 1 recommendation in the 2021 guidelines for acute heart failure (AHF). While …
been a key component in treating pulmonary oedema since the 1960s and have a
Class 1 recommendation in the 2021 guidelines for acute heart failure (AHF). While …
Okechukwu Ogah
Jun 22, 2024, 5:02:48 AM6/22/24
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Effects of Dapagliflozin on Body Composition and Its Relation to Hemodynamics in Heart Failure With Preserved Ejection Fraction
JA Naser, A Tada, T Harada, YNV Reddy, RE Carter… - Circulation, 2024
Excess adiposity, particularly increases in visceral fat, play a pivotal role in the
pathophysiology of heart failure with preserved ejection fraction (HFpEF). 1
Medicines targeting excess body fat are emerging as effective treatments, including …
pathophysiology of heart failure with preserved ejection fraction (HFpEF). 1
Medicines targeting excess body fat are emerging as effective treatments, including …
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[HTML] Real-life effectiveness of sacubitril/valsartan in older Belgians with heart failure, reduced ejection fraction and most severe symptoms
E Maury, A Belmans, K Bogaerts, S Vancayzeele… - Scientific Reports, 2024
We assessed the real-world effectiveness of sacubitril/valsartan in patients with
chronic heart failure (HF) and reduced ejection fraction (HFrEF) with an emphasis on
those with older age (≥ 75 years) or with New York Heart Association (NYHA) class …
chronic heart failure (HF) and reduced ejection fraction (HFrEF) with an emphasis on
those with older age (≥ 75 years) or with New York Heart Association (NYHA) class …
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Change in left atrial function and volume predicts incident heart failure with preserved and reduced ejection fraction: Multi-Ethnic Study of Atherosclerosis
DJ Lim, V Varadarajan, T Quinaglia, T Pezel, C Wu… - European Heart Journal …, 2024
Aims The role of change in left atrial (LA) parameters prior to the onset of heart failure
(HF) remains unclear. We used cardiac magnetic resonance (CMR) imaging to
investigate the relationship between longitudinal change in LA function and incident …
(HF) remains unclear. We used cardiac magnetic resonance (CMR) imaging to
investigate the relationship between longitudinal change in LA function and incident …
| | | |
[HTML] Safety and Efficacy of Dapagliflozin in Patients with Heart Failure with Reduced Ejection Fraction: Multicentre Retrospective Study on Echocardiographic Parameters …
I Battistoni, G Pongetti, E Falchetti, I Giannini, R Olivieri… - Journal of Clinical Medicine, 2024
Objectives: Dapagliflozin has shown efficacy in clinical trials in patients with heart
failure and reduced ejection fraction (HFrEF). However, real-world data on its use
and outcomes in routine clinical practice are limited. We aimed to evaluate the …
failure and reduced ejection fraction (HFrEF). However, real-world data on its use
and outcomes in routine clinical practice are limited. We aimed to evaluate the …
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[HTML] Liraglutide ameliorates TAC-induced cardiac hypertrophy and heart failure by upregulating expression level of ANP expression
R Li, K Zhang, Z Xu, Y Yu, D Wang, K Li, W Liu, J Pan - Heliyon, 2024
Recent studies have underscored the cardioprotective properties of liraglutide. This
research explores its impact on cardiac hypertrophy and heart failure following
transverse aortic constriction (TAC). We found that liraglutide administration …
research explores its impact on cardiac hypertrophy and heart failure following
transverse aortic constriction (TAC). We found that liraglutide administration …
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[HTML] A machine learning-derived score to effectively identify heart failure with preserved ejection fraction
KC Bermea, JP Lovell, AG Hays, E Goerlich… - JACC: Advances, 2024
Background The diagnosis of heart failure with preserved ejection fraction (HFpEF)
in the clinical setting remains challenging, especially in obese patients. Objectives
This study aimed to identify novel predictors of HFpEF well suited for obese patients …
in the clinical setting remains challenging, especially in obese patients. Objectives
This study aimed to identify novel predictors of HFpEF well suited for obese patients …
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[PDF] Epidemiology of Acute Heart Failure in Myocardial Infarction
BM Nazhmidinovna - International Journal of Integrative and Modern …, 2024
Early detection of predictors of acute heart failure (ACF), the fact of myocardial
necrosis, high diagnostic accuracy in the first hours of the disease in patients with
acute coronary syndrome is the most important task of emergency cardiology …
necrosis, high diagnostic accuracy in the first hours of the disease in patients with
acute coronary syndrome is the most important task of emergency cardiology …
Okechukwu Ogah
Jun 22, 2024, 5:14:15 AM6/22/24
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Serum bile acid profiles are associated with heart failure with preserved ejection fraction in patients with metabolic dysfunction‐associated fatty liver disease: An …
XD Zhou, CF Xu, QF Chen, MD Shapiro, GYH Lip… - Diabetes, Obesity and Metabolism
Aim To analyse the association between serum bile acid (BA) profile and heart
failure (HF) with preserved ejection fraction (HFpEF) in patients with metabolic
dysfunction‐associated fatty liver disease (MAFLD). Methods We enrolled 163 …
failure (HF) with preserved ejection fraction (HFpEF) in patients with metabolic
dysfunction‐associated fatty liver disease (MAFLD). Methods We enrolled 163 …
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Outcomes of on-label reduced-dose edoxaban in octogenarian patients with atrial fibrillation
HJ Lee, SH Lee, JW Kim, JY Kim, SJ Park, KM Park… - Europace, 2024
Background Non-vitamin K antagonist oral anticoagulants (NOACs) are effective in
preventing thromboembolisms and reduce the risk of bleeding compared with
warfarin. There are few reports on the outcomes of on-label reduced-dose NOACs …
preventing thromboembolisms and reduce the risk of bleeding compared with
warfarin. There are few reports on the outcomes of on-label reduced-dose NOACs …
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PCR233 Adherence and Persistence of Oral Anticoagulants for Treatment of Atrial Fibrillation across Stroke and Bleeding Risk Strata
G Ko, E Brouwer, V Dayer, A Katta, S Ramsey, M Lopes… - Value in Health, 2024
Objectives Suboptimal adherence to oral anticoagulants (OACs) to treat atrial
fibrillation (AF) can lead to poor treatment outcomes. This study aimed to evaluate
variations in adherence and persistence to OACs among AF patients across stroke …
fibrillation (AF) can lead to poor treatment outcomes. This study aimed to evaluate
variations in adherence and persistence to OACs among AF patients across stroke …
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The Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Atrial Electromechanical Conduction Time.
E Çelik, M Kerkütlüoğlu, M Şahin, E Aksu, AS Balcıoğlu - Archives of the Turkish …, 2024
Objective: This study aims to explore the impact of sodium-glucose cotransporter-2
(SGLT-2) inhibitors, a newer class of oral antidiabetic drugs, on atrial
electromechanical delay (EMD) in patients with type 2 diabetes mellitus (DM). This is …
(SGLT-2) inhibitors, a newer class of oral antidiabetic drugs, on atrial
electromechanical delay (EMD) in patients with type 2 diabetes mellitus (DM). This is …
Okechukwu Ogah
Jun 30, 2024, 11:58:02 AM6/30/24
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Change in left atrial function and volume predicts incident heart failure with preserved and reduced ejection fraction: Multi-Ethnic Study of Atherosclerosis
DJ Lim, V Varadarajan, T Quinaglia, T Pezel, C Wu… - European Heart Journal …, 2024
Aims The role of change in left atrial (LA) parameters prior to the onset of heart failure
(HF) remains unclear. We used cardiac magnetic resonance (CMR) imaging to
investigate the relationship between longitudinal change in LA function and incident …
(HF) remains unclear. We used cardiac magnetic resonance (CMR) imaging to
investigate the relationship between longitudinal change in LA function and incident …
| | | |
[HTML] Phenotypic Characteristics of Acute Decompensated Heart Failure With Preserved Ejection Fraction in Japanese Population
Y Sotomi, T Nagai, S Hikoso, T Yoshikawa, Y Saito… - JACC: Asia, 2024
This figure summarizes the differences in the features of the phenotyping model
across the acute HFpEF phenogroups in both registries. Features are arranged
clockwise in descending order of discriminative power. The radar chart illustrates the …
across the acute HFpEF phenogroups in both registries. Features are arranged
clockwise in descending order of discriminative power. The radar chart illustrates the …
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[HTML] Accurate Modeling of Ejection Fraction and Stroke Volume With Mobile Phone Auscultation: Prospective Case-Control Study
M Huecker, C Schutzman, J French, K El-Kersh… - JMIR cardio, 2024
Background: Heart failure (HF) contributes greatly to morbidity, mortality, and health
care costs worldwide. Hospital readmission rates are tracked closely and determine
federal reimbursement dollars. No current modality or technology allows for accurate …
care costs worldwide. Hospital readmission rates are tracked closely and determine
federal reimbursement dollars. No current modality or technology allows for accurate …
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[PDF] Atrial fibrillation, venous thromboembolism, and risk of pulmonary hypertension: A Swedish Nationwide Register Study
C Hjalmarsson, M Lindgren, N Bergh, BCR Hornestam… - medRxiv, 2024
Background: Atrial fibrillation (AF) is a recognized risk factor for systemic arterial-and
venous thromboembolism (VTE), including pulmonary embolism (PE), and may
thereby contribute to the development of chronic thrombo-embolic pulmonary …
venous thromboembolism (VTE), including pulmonary embolism (PE), and may
thereby contribute to the development of chronic thrombo-embolic pulmonary …
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Cardiovascular‐kidney‐metabolic overlap in heart failure with preserved ejection fraction: Cardiac structure and function, clinical outcomes, and response to sacubitril …
MCH Lassen, JW Ostrominski, BL Claggett, M Packer… - European Journal of Heart …, 2024
Aims Cardiovascular‐kidney‐metabolic (CKM) multimorbidity is prevalent among
individuals with heart failure (HF), but whether cardiac structure and function, clinical
outcomes, and treatment response to sacubitril/valsartan vary in relation to CKM …
individuals with heart failure (HF), but whether cardiac structure and function, clinical
outcomes, and treatment response to sacubitril/valsartan vary in relation to CKM …
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[PDF] The National Health Insurance Scheme (NHIS) in Nigeria: current issues and implementation challenges
OI Eze, A Iseolorunkanmi, D Adeloye - Journal of Global Health Economics and Policy, 2024
The National Health Insurance Scheme (NHIS) in Nigeria, despite its critical role in
aiming for Universal Health Coverage, faces significant challenges. Initiated in 2005
with the goal of universal healthcare access by 2015, the scheme has struggled with …
aiming for Universal Health Coverage, faces significant challenges. Initiated in 2005
with the goal of universal healthcare access by 2015, the scheme has struggled with …
Okechukwu Ogah
Jun 30, 2024, 12:02:45 PM6/30/24
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[HTML] Direct oral anticoagulants for oral anticoagulants-naïve Asian patients with atrial fibrillation and end-stage renal disease undergoing dialysis
JH Roh, YG Kim, D Kim, S Park, KS Park, M Kim… - Scientific Reports, 2024
In Asian patients with atrial fibrillation (AF) and end-stage renal disease (ESRD)
undergoing dialysis, the use of direct oral anticoagulants (DOACs) remains
debatable. From the national health insurance claims data in South Korea, we …
undergoing dialysis, the use of direct oral anticoagulants (DOACs) remains
debatable. From the national health insurance claims data in South Korea, we …
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[HTML] The prescription of beta-blockers in older patients with heart failure with reduced ejection fraction: an observational study in Vietnam
T Van Nguyen, HTK Nguyen, WJ Wong, F Ahmad… - Scientific Reports, 2024
This study in older hospitalized patients with heart failure with reduced ejection
fraction (HFrEF) aimed to examine the prevalence of beta-blocker prescription and its
associated factors. A total of 190 participants were recruited from July 2019 to July …
fraction (HFrEF) aimed to examine the prevalence of beta-blocker prescription and its
associated factors. A total of 190 participants were recruited from July 2019 to July …
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Integrating platelet reactivity in the age, creatinine and ejection fraction score to predict clinical outcomes following percutaneous coronary intervention in patients with …
L Paolucci, F Mangiacapra, MM Viscusi, S Sergio… - Heart and Vessels, 2024
To evaluate if integrating platelet reactivity (PR) evaluation in the original age,
creatinine and ejection fraction (ACEF) score could improve the diagnostic accuracy
of the model in patients with stable coronary artery disease (CAD). We enrolled …
creatinine and ejection fraction (ACEF) score could improve the diagnostic accuracy
of the model in patients with stable coronary artery disease (CAD). We enrolled …
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Recurrent Ischemic Stroke in Patients With Atrial Fibrillation While Receiving Oral Anticoagulants
MF Hindsholm, LAG Rodríguez, A Brandes, J Hallas… - JAMA neurology, 2024
Importance Patients with atrial fibrillation (AF) can have an ischemic stroke (IS)
despite oral anticoagulant (OAC) treatment. Knowledge regarding the association
between OAC discontinuation and the subsequent risk of recurrent IS in patients with …
despite oral anticoagulant (OAC) treatment. Knowledge regarding the association
between OAC discontinuation and the subsequent risk of recurrent IS in patients with …
| | | |
NO El Caidi, JD Lukoschewitz, OW Nielsen, J Hove… - Danish Medical Journal, 2024
ABSTRACT INTRODUCTION. INTRODUCTION. Intravenous loop diuretics have
been a key component in treating pulmonary oedema since the 1960s and have a
Class 1 recommendation in the 2021 guidelines for acute heart failure (AHF). While …
been a key component in treating pulmonary oedema since the 1960s and have a
Class 1 recommendation in the 2021 guidelines for acute heart failure (AHF). While …
| | | |
[PDF] Epidemiology of Acute Heart Failure in Myocardial Infarction
BM Nazhmidinovna - International Journal of Integrative and Modern …, 2024
Early detection of predictors of acute heart failure (ACF), the fact of myocardial
necrosis, high diagnostic accuracy in the first hours of the disease in patients with
acute coronary syndrome is the most important task of emergency cardiology …
necrosis, high diagnostic accuracy in the first hours of the disease in patients with
acute coronary syndrome is the most important task of emergency cardiology …
Okechukwu Ogah
Jul 8, 2024, 9:05:53 AM7/8/24
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[PDF] The serum metabolomic profiles of atrial fibrillation patients treated with direct oral anticoagulants or vitamin K antagonists
A Vignoli, AM Gori, M Berteotti, F Cesari, B Giusti… - Life Sciences, 2024
Aims Long-term oral anticoagulation is the primary therapy for preventing ischemic
stroke in patients with atrial fibrillation (AF). Different types of oral anticoagulant
drugs can have specific effects on the metabolism of patients. Here we characterize …
stroke in patients with atrial fibrillation (AF). Different types of oral anticoagulant
drugs can have specific effects on the metabolism of patients. Here we characterize …
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[PDF] Prevalence And Determinants Of Pulmonary Hypertension In Rheumatic Heart Disease Patients At University Of Gondar Comprehensive Specialized Hospital: A …
FA Molla, DG Ayalew, HA Astatk, AW Teshager… - 2024
Methods An institution-based retrospective study was conducted by reviewing
medical records of patients at adult echocardiographic unit from September, 2018 to
September, 2023. Systolic PAP> 35mmHg using 2D echocardiography was used to …
medical records of patients at adult echocardiographic unit from September, 2018 to
September, 2023. Systolic PAP> 35mmHg using 2D echocardiography was used to …
Okechukwu Ogah
Jul 11, 2024, 1:33:06 AM7/11/24
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Increased Spironolactone Dosing in Acute Heart Failure Alters Potassium Homeostasis but Does Not Enhance Decongestion
PS Natov, JB Ivey-Miranda, ZL Cox, VS Rao, J Butler… - Journal of Cardiac Failure, 2024
Abstract Background The ATHENA-HF clinical trial found no improvements in
natriuretic peptide levels or clinical congestion when spironolactone 100 mg/day for
96 hours was used in addition to usual treatment for acute heart failure. Methods We …
natriuretic peptide levels or clinical congestion when spironolactone 100 mg/day for
96 hours was used in addition to usual treatment for acute heart failure. Methods We …
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[PDF] Impaired longitudinal systolic–diastolic coupling and cardiac response to exercise in patients with hypertrophic cardiomyopathy
JP MacNamara, WM Turlington, KA Dias… - Echocardiography, 2024
Background In patients with hypertrophic cardiomyopathy (HCM), impaired
augmentation of stroke volume and diastolic dysfunction contribute to exercise
intolerance. Systolic–diastolic (S‐D) coupling characterizes how systolic contraction …
augmentation of stroke volume and diastolic dysfunction contribute to exercise
intolerance. Systolic–diastolic (S‐D) coupling characterizes how systolic contraction …
Okechukwu Ogah
Jul 14, 2024, 1:50:53 PM7/14/24
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DJ Lim, V Varadarajan, T Quinaglia, T Pezel, C Wu… - European Heart Journal …, 2024
Aims The role of change in left atrial (LA) parameters prior to the onset of heart failure
(HF) remains unclear. We used cardiac magnetic resonance (CMR) imaging to
investigate the relationship between longitudinal change in LA function and incident …
(HF) remains unclear. We used cardiac magnetic resonance (CMR) imaging to
investigate the relationship between longitudinal change in LA function and incident …
Okechukwu Ogah
Jul 14, 2024, 1:51:19 PM7/14/24
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[HTML] Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection …
JE Doiron, H Xia, X Yu, AR Nevins, KB LaPenna… - British Journal of …, 2024
Abstract Background and Purpose Sodium glucose cotransporter 2 inhibitors
(SGLT2i) have emerged as a potent therapy for heart failure with preserved ejection
fraction (HFpEF). Hydrogen sulphide (H2S), a well‐studied cardioprotective agent …
(SGLT2i) have emerged as a potent therapy for heart failure with preserved ejection
fraction (HFpEF). Hydrogen sulphide (H2S), a well‐studied cardioprotective agent …
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Efficacy and safety of direct oral anticoagulants versus warfarin in the treatment of cerebral venous sinus thrombosis
E Sadeghi Hokmabadi, A Daei Sorkhabi, A Sarkesh… - Acta Neurologica Belgica, 2024
Background Given the evolving application and promising outcomes of direct oral
anticoagulants (DOACs) in various thromboembolic conditions, we aimed to
compare the efficacy and safety of DOACs with warfarin in the post-acute treatment of …
anticoagulants (DOACs) in various thromboembolic conditions, we aimed to
compare the efficacy and safety of DOACs with warfarin in the post-acute treatment of …
| | | |
Coronary Artery Disease Characterization And Plaque Analysis In Patients With Hypertrophic Cardiomyopathy-A Comparative Study
T Grinberg, A Shiyovich, D Vronsky, T Lerman… - Journal of Cardiovascular …, 2024
Methods: Consecutive patients with HCM referred to CTA for stable chest pain
evaluation were included. Patients with known obstructive CAD or previous coronary
intervention were excluded. Total coronary plaque volume was calculated using a …
evaluation were included. Patients with known obstructive CAD or previous coronary
intervention were excluded. Total coronary plaque volume was calculated using a …
Okechukwu Ogah
Jul 17, 2024, 3:04:44 AM7/17/24
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Time to Benefit and Harm of Direct Oral Anticoagulants in Device-Detected Atrial Fibrillation: A Pooled Analysis of the NOAH-AFNET 6 and ARTESiA Trials
C Huang, L Li, W Liu, Y Fang, S Jiang, Y Li… - Heart Rhythm, 2024
Abstract Background Direct oral anticoagulants (DOACs) reduce stroke risk in
patients with device-detected atrial fibrillation (DD-AFib) but increase major bleeding
risk. The time to benefit (TTB) and time to harm (TTH) are not well quantified …
patients with device-detected atrial fibrillation (DD-AFib) but increase major bleeding
risk. The time to benefit (TTB) and time to harm (TTH) are not well quantified …
| | | |
[PDF] Warfarin Therapy and Percutaneous Left Atrial Appendage Closure for a Patient with Atrial Fibrillation and Antithrombin-III Deficiency
S Shimohama, M Katsumata, S Azami, S Kitagawa… - The Keio Journal of …, 2024
Some patients develop ischemic stroke despite taking direct oral anticoagulants
because of the presence of other risk factors such as coagulopathies. A 65-year-old
male patient with non-valvular atrial fibrillation (NVAF) taking rivaroxaban was …
because of the presence of other risk factors such as coagulopathies. A 65-year-old
male patient with non-valvular atrial fibrillation (NVAF) taking rivaroxaban was …
| | | |
Prognostic association of circulating relaxin-2 in acute heart failure
M Pintalhao, F Vasques-Nóvoa, AS Barros, P Lourenço… - International Journal of …, 2024
Background Despite the increasing interest in the study of the endogenous relaxin
system in heart failure (HF), its role as a prognostic marker in acute HF remains
unclear. We aimed to evaluate the association of relaxin-2 circulating levels with 6 …
system in heart failure (HF), its role as a prognostic marker in acute HF remains
unclear. We aimed to evaluate the association of relaxin-2 circulating levels with 6 …
| | | |
[PDF] The Role of NT-proBNP in the Diagnosis of Peripartum Cardiomyopathy with Multiple Left Ventricular Thrombus: A Case Report
YOG Setyanda, R Yaswir - Bioscientia Medicina: Journal of Biomedicine and …, 2024
Background: Peripartum cardiomyopathy (PPCM) is a rare but serious condition
characterized by left ventricular dysfunction in late pregnancy or early postpartum.
Early diagnosis is essential to prevent complications such as thromboembolism. N …
characterized by left ventricular dysfunction in late pregnancy or early postpartum.
Early diagnosis is essential to prevent complications such as thromboembolism. N …
Okechukwu Ogah
Jul 19, 2024, 1:14:41 AM7/19/24
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[HTML] Association between serum osmolality and 28-day all-cause mortality in patients with heart failure and reduced ejection fraction: a retrospective cohort study from the …
Q Zou, J Li, P Lin, J Ma, Z Wei, T Tao, G Han, S Sun - Frontiers in Endocrinology, 2024
Background Previous studies have not thoroughly explored the impact of serum
osmolality levels on early mortality in heart failure and reduced ejection fraction
(HFrEF) patients. The purpose of this study was to investigate the relationship …
osmolality levels on early mortality in heart failure and reduced ejection fraction
(HFrEF) patients. The purpose of this study was to investigate the relationship …
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Effect of Sacubitril/Valsartan Combination on Abnormal ECG Findings in Patients with Heart Failure with Reduced Ejection Fraction
A Aly, H Shehata, L Allam, H Eldamanhoury - QJM: An International Journal of …, 2024
Background The mortality rate of patients suffering from choronic heart failure is still
high despite advantages in diagnosis and treatment. A new therapeutic class of
agents acting on the renin angiotensin aldosterone system (RAAS) and neutral …
high despite advantages in diagnosis and treatment. A new therapeutic class of
agents acting on the renin angiotensin aldosterone system (RAAS) and neutral …
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[HTML] Ventricular remodeling and hemodynamic changes in heart failure patients with non-ischemic dilated cardiomyopathy following dapagliflozin initiation
A Hassan, K Samaan, A Asfour, Y Baghdady… - The Egyptian Heart Journal, 2024
Background In heart failure with reduced ejection fraction (HFrEF), sodium–glucose
co-transporter inhibitors (SGLT-2i) have persistently shown cardiovascular benefits
through different trials. However, their impact on ventricular remodeling and cardiac …
co-transporter inhibitors (SGLT-2i) have persistently shown cardiovascular benefits
through different trials. However, their impact on ventricular remodeling and cardiac …
| | | |
[PDF] Prevalence of Hypertension Among Pregnant Women When Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines …
MJ Fassett, K Reynolds
IMPORTANCE Hypertensive disorders of pregnancy are a leading cause of maternal
morbidity and mortality. The impact of applying recent guideline definitions for
nonpregnant adults to pregnant women is unclear. OBJECTIVE To determine …
morbidity and mortality. The impact of applying recent guideline definitions for
nonpregnant adults to pregnant women is unclear. OBJECTIVE To determine …
Okechukwu Ogah
Jul 19, 2024, 3:17:40 AM7/19/24
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[PDF] Treatment pathways in patients with heart failure with preserved ejection fraction and obesity: perspectives from cardiology specialists and patients
J Butler, SJ Shah, M Magwire, C Campos, MS Usman… - Global Cardiology, 2024
Background: Obesity, highly prevalent in patients with heart failure with preserved
ejection fraction (HFpEF), may make HFpEF more difficult to diagnose by masking its
signs. The aim of this study was to identify challenges patients and healthcare …
ejection fraction (HFpEF), may make HFpEF more difficult to diagnose by masking its
signs. The aim of this study was to identify challenges patients and healthcare …
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[HTML] Left ventricular geometry characteristics and clinical outcomes in hemodialysis patients with heart failure with preserved ejection fraction
Y Zhang, X Guo, S Chen, Y Wang, J Li, X Sun, X Huang - BMC Cardiovascular …, 2024
Background The relationships among left heart remodeling, cardiac function, and
cardiovascular events (CEs) in patients with heart failure (HF) with preserved
ejection fraction (HFpEF) undergoing maintenance hemodialysis (MHD) remain …
cardiovascular events (CEs) in patients with heart failure (HF) with preserved
ejection fraction (HFpEF) undergoing maintenance hemodialysis (MHD) remain …
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[PDF] Direct Oral Anticoagulants versus Vitamin K Antagonists for Left Ventricular Thrombus: A Meta-Analysis with Trial Sequential Analysis
E Pasqualotto, DM Gewehr, ROM Ferreira, MP Chavez… - Arq. Bras. Cardiol., 2024
Background Vitamin K antagonists (VKAs) are the recommended first-line treatment
for left ventricular thrombus (LVT); however, direct oral anticoagulants (DOACs) have
been considered an alternative therapy. Objectives To evaluate the efficacy and …
for left ventricular thrombus (LVT); however, direct oral anticoagulants (DOACs) have
been considered an alternative therapy. Objectives To evaluate the efficacy and …
Okechukwu Ogah
Jul 19, 2024, 3:21:25 AM7/19/24
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An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score
YNV Reddy, RE Carter, V Sundaram, DM Kaye… - Nature Medicine, 2024
Heart failure with preserved ejection fraction (HFpEF) is under-recognized in clinical
practice. Although a previously developed risk score, termed H 2 FPEF, can be used
to estimate HFpEF probability, this score requires imaging data, which is often …
practice. Although a previously developed risk score, termed H 2 FPEF, can be used
to estimate HFpEF probability, this score requires imaging data, which is often …
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[PDF] European Society of Cardiology quality indicators update for the care and outcomes of adults with heart failure. The Heart Failure Association of the ESC
A Abdin, C Wilkinson, S Aktaa, M Böhm, M Polovina… - European Journal of Heart …, 2024
ABSTRACT Aims To update the European Society of Cardiology (ESC) quality
indicators (QIs) for the evaluation of the care and outcomes of adults with heart
failure. Methods and results The Working Group comprised experts in heart failure …
indicators (QIs) for the evaluation of the care and outcomes of adults with heart
failure. Methods and results The Working Group comprised experts in heart failure …
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[HTML] Assessing the relationship between lipoprotein (a) levels and blood pressure among hypertensive patients beyond conventional measures. An observational study
N Vazquez-Agra, A Cruces-Sande, S Barbosa-Gouveia… - Scientific Reports, 2024
Abstract High lipoprotein (a)(Lp (a)) levels are associated with an increased risk of
arterial hypertension (AHT) and atherosclerotic cardiovascular disease. However,
little is known about the detailed profile of AHT based on Lp (a) levels. This …
arterial hypertension (AHT) and atherosclerotic cardiovascular disease. However,
little is known about the detailed profile of AHT based on Lp (a) levels. This …
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Short-term effect of Dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, on patients with rheumatic mitral regurgitation and preserved left ventricular systolic …
HM Farrag, RI Fahim, M Abdelkader Abdelwahab - Minia Journal of Medical …, 2024
Background: SGLT2 inhibitors have been demonstrated to lower cardiovascular
mortality risk and HF worsening in patients of HF with reduced, mildly reduced and
preserved ejection fraction regardless of diabetes status (1) However, its effect on …
mortality risk and HF worsening in patients of HF with reduced, mildly reduced and
preserved ejection fraction regardless of diabetes status (1) However, its effect on …
Okechukwu Ogah
Jul 20, 2024, 3:31:16 AM7/20/24
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Distinguishing pathophysiological features of heart failure with reduced and preserved ejection fraction: A comparative analysis of two mouse models
A Méndez‐Fernández, Á Fernández‐Mora… - The Journal of Physiology, 2024
Heart failure (HF) is a heterogeneous condition that can be categorized according to
the left ventricular ejection fraction (EF) into HF with reduced (HFrEF) or preserved
(HFpEF) EF. Although HFrEF and HFpEF share some common clinical …
the left ventricular ejection fraction (EF) into HF with reduced (HFrEF) or preserved
(HFpEF) EF. Although HFrEF and HFpEF share some common clinical …
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[HTML] Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy
AA Derda, M Abelmann, K Sonnenschein, JT Sieweke… - Frontiers in Cardiovascular …, 2024
Background Hypertrophic cardiomyopathy (HCM), the most common genetic heart
disease, is classified into hypertrophic non-obstructive and hypertrophic obstructive
cardiomyopathy (HOCM). Patients with HOCM and coexisting heart failure or arterial …
disease, is classified into hypertrophic non-obstructive and hypertrophic obstructive
cardiomyopathy (HOCM). Patients with HOCM and coexisting heart failure or arterial …
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[HTML] Effects of dapagliflozin on myoglobin efflux from cardiomyocyte during myocardial ischemia/reperfusion in anesthetized rats
T Hayashida, Y Kuroko, S Shimizu, T Akiyama… - Scientific Reports, 2024
It has been suggested that sodium-glucose cotransporter 2 (SGLT2) inhibitors have
cardioprotective effects during myocardial ischemia/reperfusion (I/R) independent of
glucose-lowering action. However, the effects of SGLT2 inhibitors on structural …
cardioprotective effects during myocardial ischemia/reperfusion (I/R) independent of
glucose-lowering action. However, the effects of SGLT2 inhibitors on structural …
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[PDF] Prevalence and prognosis of aortic valve diseases in patients hospitalized with heart failure with mildly reduced ejection fraction
T Schupp, N Abel, M Schmidberger, MK Höpfner… - European Journal of Heart …, 2024
Aims Data regarding the characterization and outcomes of patients with heart failure
(HF) with mildly reduced ejection fraction (HFmrEF) is scarce. This study investigates
the characteristics and prognostic impact of native aortic valve diseases (AVD) in …
(HF) with mildly reduced ejection fraction (HFmrEF) is scarce. This study investigates
the characteristics and prognostic impact of native aortic valve diseases (AVD) in …
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[PDF] The prevalence of monotherapy and combination therapy in hypertension in China from 2019 to 2021: A nationwide population‐based cross‐sectional study
X Luo, W Liu, N Sun, P Bo, Y Chen, Q Han, N Li, X Lu… - The Journal of Clinical …, 2024
There are no nationwide surveys on antihypertensive drugs in China. In order to
assess the current status of antihypertensive drug therapy in patients with
hypertension and analyzed factors that may affect combination therapy, using …
assess the current status of antihypertensive drug therapy in patients with
hypertension and analyzed factors that may affect combination therapy, using …
Okechukwu Ogah
Jul 22, 2024, 1:04:30 AM7/22/24
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[PDF] Clinical Significance of Exercise Pulmonary Hypertension With a Negative Diastolic Stress Test for Suspected Heart Failure With Preserved Ejection Fraction
J Verwerft, J Stassen, M Falter, Y Bekhuis… - Journal of the American …, 2024
Background Half of patients with heart failure with preserved ejection fraction
(HFpEF) remain undiagnosed by resting evaluation alone. Therefore, exercise
testing is proposed. The diastolic stress test (DST), however, has limited sensitivity …
(HFpEF) remain undiagnosed by resting evaluation alone. Therefore, exercise
testing is proposed. The diastolic stress test (DST), however, has limited sensitivity …
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Prognostic of dapagliflozin in patients with ejection fraction preserving heart failure combined with paroxysmal atrial fibrillation
LI Ji, SHI Binhao, HAO Yancheng, W Jianfei - J Clin Cardiol, 2024
Prognostic of dapagliflozin in patients with ejection fraction preserving heart failure
combined with paroxysmal atrial fibrillation Homepage Journals 1.{{journal.titleEn}} {{journal.titleEn}}
{{journal.titleEn}} {{journal.titleEn}} {{subColumn.name}} 2.{{journal.titleEn}} {{journal.titleEn}} …
combined with paroxysmal atrial fibrillation Homepage Journals 1.{{journal.titleEn}} {{journal.titleEn}}
{{journal.titleEn}} {{journal.titleEn}} {{subColumn.name}} 2.{{journal.titleEn}} {{journal.titleEn}} …
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[PDF] Heart Failure with Mildly Reduced Ejection Fraction (HFmrEF) Leading to Concurrent Cerebral and Cerebellar Ischemia in a Young Adult: A Case Report.
AU Wasim, M Ahmed, M Imtiaz, H Malik, J Abbas - Heart Failure, 2024
Background Heart Failure with Mid-Range Ejection Fraction (HFmrEF) is a newly
recognized category of heart failure, sharing features of both reduced and preserved
ejection fraction heart failure. This overlap presents diagnostic challenges …
recognized category of heart failure, sharing features of both reduced and preserved
ejection fraction heart failure. This overlap presents diagnostic challenges …
| | | |
Inpatient mortality and outcomes of COVID-19 among patients with non-ischemic cardiomyopathy: A propensity matched analysis
MFA Baig, K Chaliki - Heart & Lung: The Journal of Cardiopulmonary and …, 2024
Background Patients with chronic medical conditions, particularly cardiovascular
diseases, are at a greater risk of adverse outcomes due to COVID-19. The effect of
COVID-19 on patients with non-ischemic cardiomyopathy (NICM) is not known well …
diseases, are at a greater risk of adverse outcomes due to COVID-19. The effect of
COVID-19 on patients with non-ischemic cardiomyopathy (NICM) is not known well …
Okechukwu Ogah
Jul 24, 2024, 10:39:08 AM7/24/24
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Sacubitril/valsartan alleviates sepsis-induced myocardial injury in rats via dual angiotensin receptor-neprilysin inhibition and modulation of inflammasome/caspase 1 …
MMM Refaie, M El-Hussieny, AMA Bayoumi… - European Journal of …, 2024
Sepsis is a life-threatening situation that ultimately affects cardiac function, leading to
cardiomyopathy and myocardial injury as a result of uncontrolled response to
infection. Till now, there is limited effective treatment to rescue those cases. Thus …
cardiomyopathy and myocardial injury as a result of uncontrolled response to
infection. Till now, there is limited effective treatment to rescue those cases. Thus …
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Increased risk of end-stage kidney disease in patients with chronic kidney disease and heart failure with reduced ejection fraction
S Al-Chalabi, M Poulose, S Rengarajan, PR Kalra… - CardioRenal Medicine, 2024
Introduction: The prevalence of heart failure (HF) is more common in people with
advanced non-dialysis chronic kidney disease (ND-CKD) compared to the general
population. It is well known that HF with reduced ejection fraction (HFrEF) is …
advanced non-dialysis chronic kidney disease (ND-CKD) compared to the general
population. It is well known that HF with reduced ejection fraction (HFrEF) is …
Okechukwu Ogah
Jul 25, 2024, 1:55:29 AM7/25/24
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[HTML] Heart Failure With Preserved Ejection Fraction and Atrial Fibrillation: Are Beta-Blockers Still Relevant?
J Hyun - International Journal of Heart Failure, 2024
While the efficacy of beta-blockers (BBs) in patients with heart failure (HF) with
reduced ejection fraction is well-established, 1, 2, 3) the evidence supporting their
use in patients with heart failure with preserved ejection fraction (HFpEF) is limited …
reduced ejection fraction is well-established, 1, 2, 3) the evidence supporting their
use in patients with heart failure with preserved ejection fraction (HFpEF) is limited …
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[HTML] Sex differences in clinical profile, left ventricular remodeling and cardiovascular outcomes among diabetic patients with heart failure and reduced ejection fraction: a …
K Shi, G Zhang, H Fu, XM Li, L Jiang, Y Gao, WL Qian… - Cardiovascular Diabetology, 2024
Heart failure with reduced ejection fraction (HFrEF) is associated with a high rate of
mortality and morbidity. Evidence has shown that sex differences may be an
important contributor to phenotypic heterogeneity in patients with HFrEF. Although …
mortality and morbidity. Evidence has shown that sex differences may be an
important contributor to phenotypic heterogeneity in patients with HFrEF. Although …
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The efficacy of sacubitril/valsartan in patients receiving peritoneal dialysis with diabetes and heart failure with preserved ejection fraction
X Bian, J Ma, Q Su, Q Yu, J Huang, S Bao, J Ying - Clinical nephrology
Objective To investigate the efficacy of sacubitril/valsartan in the treatment of
peritoneal dialysis (PD) in patients with diabetes and heart failure with preserved
ejection fraction (HFpEF). Materials and methods Patients with diabetes who …
peritoneal dialysis (PD) in patients with diabetes and heart failure with preserved
ejection fraction (HFpEF). Materials and methods Patients with diabetes who …
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[PDF] Clinical Benefit of Sacubitril/Valsartan for Hypertensive Patients in Daily Practice and Predictors of Its Antihypertensive Effect
T Horio, Y Iwashima, M Yoshiyama, D Fukuda… - Circulation Reports, 2024
Background: The blood pressure (BP)-lowering effect of sacubitril/valsartan (Sac/Val)
is greater than that of angiotensin II receptor blockers (ARBs) but in in real-world
clinical practice, Sac/Val is used in a variety of patterns other than switching from …
is greater than that of angiotensin II receptor blockers (ARBs) but in in real-world
clinical practice, Sac/Val is used in a variety of patterns other than switching from …
| | | |
[PDF] Ten‐Year Trend of Oral Anticoagulation Use in Postoperative and Nonpostoperative Atrial Fibrillation in Routine Clinical Practice
X Yao, HK Van Houten, KC Siontis, PA Friedman… - Journal of the American …, 2024
Background The study aimed to describe the patterns and trends of initiation,
discontinuation, and adherence of oral anticoagulation (OAC) in patients with new‐
onset postoperative atrial fibrillation (POAF), and compare with patients newly …
discontinuation, and adherence of oral anticoagulation (OAC) in patients with new‐
onset postoperative atrial fibrillation (POAF), and compare with patients newly …
Okechukwu Ogah
Jul 26, 2024, 4:12:39 AM7/26/24
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Increased risk of end-stage kidney disease in patients with chronic kidney disease and heart failure with reduced ejection fraction
S Al-Chalabi, M Poulose, S Rengarajan, PR Kalra… - CardioRenal Medicine, 2024
Introduction: The prevalence of heart failure (HF) is more common in people with
advanced non-dialysis chronic kidney disease (ND-CKD) compared to the general
advanced non-dialysis chronic kidney disease (ND-CKD) compared to the general
population. It is well known that HF with reduced ejection fraction (HFrEF) is …
| | | |
[HTML] Empagliflozin and dapagliflozin decreased atrial monoamine oxidase expression and alleviated oxidative stress in overweight non-diabetic cardiac patients
LN Ionică, DG Buriman, AV Lința, R Șoșdean… - Molecular and Cellular …, 2024
The sodium-glucose-cotransporter 2 inhibitors (SGLT2i) are the blockbuster
antidiabetic drugs that exert cardiovascular protection via pleiotropic effects. We
have previously demonstrated that empagliflozin decreased monoamine oxidase …
antidiabetic drugs that exert cardiovascular protection via pleiotropic effects. We
have previously demonstrated that empagliflozin decreased monoamine oxidase …
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[HTML] Causes of death in patients with atrial fibrillation anticoagulated with rivaroxaban: a pooled analysis of XANTUS
P Kirchhof, S Haas, P Amarenco, AGG Turpie, M Bach… - EP Europace, 2024
Aims Anticoagulation can prevent stroke and prolong lives in patients with atrial
fibrillation (AF). However, anticoagulated patients with AF remain at risk of death. The
aim of this study was to investigate the causes of death and factors associated with …
fibrillation (AF). However, anticoagulated patients with AF remain at risk of death. The
aim of this study was to investigate the causes of death and factors associated with …
Okechukwu Ogah
Jul 28, 2024, 5:36:12 AM7/28/24
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Dapagliflozin and Right Ventricular–Pulmonary Vascular Interaction in Heart Failure With Preserved Ejection Fraction: A Secondary Analysis of a Randomized Clinical …
YNV Reddy, RE Carter, H Sorimachi, M Omar… - JAMA Cardiology
Importance Increases in pulmonary capillary wedge pressure (PCWP) during
exercise reduce pulmonary artery (PA) compliance, increase pulsatile right
ventricular (RV) afterload, and impair RV-PA coupling in patients with heart failure …
exercise reduce pulmonary artery (PA) compliance, increase pulsatile right
ventricular (RV) afterload, and impair RV-PA coupling in patients with heart failure …
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[HTML] Impact of prior oral anticoagulation on admission stroke severity in patients with atrial fibrillation
D Franc, D Sanak, M Kral, M Hutyra, M Taborsky… - Biomedical Papers, 2024
Methods: We analyzed consecutive ischemic stroke patients who had been enrolled
in the HISTORY (Heart and Ischemic STrOke Relationship studY) study registered on
ClinicalTrials. gov (identifier NCT01541163) in the year 2012 and carried out a …
in the HISTORY (Heart and Ischemic STrOke Relationship studY) study registered on
ClinicalTrials. gov (identifier NCT01541163) in the year 2012 and carried out a …
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[HTML] Left Ventricular and Atrial Deformation in Patients with Acute Decompensated Heart Failure: A Pilot Study
J Jurica, MJ Péč, M Cingel, T Bolek… - Diagnostics, 2024
Aims: The aims of this study were to compare global longitudinal strain of the left
ventricle (LV-GLS) and reservoir strain of the left atrium (R-LAS) values between
patients with acute decompensation of chronic heart failure (HF) and a control group …
ventricle (LV-GLS) and reservoir strain of the left atrium (R-LAS) values between
patients with acute decompensation of chronic heart failure (HF) and a control group …
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[HTML] Performance of HAS-BLED and DOAC scores to predict major bleeding events in atrial fibrillation patients treated with direct oral anticoagulants: A report from a …
DA Mei, JF Imberti, N Bonini, GF Romiti, B Corica… - European Journal of Internal …, 2024
Background The DOAC score has been recently proposed for bleeding risk
stratification of patients with atrial fibrillation treated with direct oral anticoagulants
(DOAC). Objective To compare the performance of HAS-BLED and DOAC score in …
stratification of patients with atrial fibrillation treated with direct oral anticoagulants
(DOAC). Objective To compare the performance of HAS-BLED and DOAC score in …
Okechukwu Ogah
Aug 6, 2024, 2:52:56 AM8/6/24
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Left atrial appendage thrombus is associated with a higher fractal dimension in patients with atrial fibrillation
M Jing, H Xi, J Li, Q Liu, H Zhu, Q Sun, Y Zhang, X Liu… - Clinical Imaging, 2024
Purpose To assess the anatomical complexity of the left atrial appendage (LAA)
using fractal dimension (FD) based on cardiac computed tomography angiography
(CTA) and the association between LAA FD and LAA thrombosis. Materials and …
using fractal dimension (FD) based on cardiac computed tomography angiography
(CTA) and the association between LAA FD and LAA thrombosis. Materials and …
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[HTML] Rivaroxaban versus vitamin K antagonist treatment on the progression of coronary calcification: the IRIVASC-trial
R Stöhr, S Reinartz, T Dirrichs, K Witte, A Schuh… - Scientific Reports, 2024
Vitamin K antagonists (VKA) remain the only option of anticoagulation for people with
mechanical valve replacement and due to their wider availability and lower
acquisition costs, VKA's remain widely used in low-and middle-income countries. It …
mechanical valve replacement and due to their wider availability and lower
acquisition costs, VKA's remain widely used in low-and middle-income countries. It …
| | | |
Impact of natriuresis on worsening renal function during episodes of acute heart failure
PC Pérez, I Fernández-Herrero, JJ Broseta… - Revista Española de …, 2024
Introduction and objectives: Worsening renal function (WRF) is a frequent
complication in acute heart failure (AHF) with a controversial prognostic value. We
aimed to study the usefulness of natriuresis to evaluate WRF. Methods: We …
complication in acute heart failure (AHF) with a controversial prognostic value. We
aimed to study the usefulness of natriuresis to evaluate WRF. Methods: We …
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[HTML] Exploring the Association Between Heart Rate Control and Rehospitalization: A Real-World Analysis of Patients Hospitalized with Heart Failure with Reduced Ejection …
FV Mody, RK Goyal, M Ajmera, KL Davis, AN Amin - Drugs-Real World Outcomes, 2024
Background In patients with heart failure with reduced ejection fraction (HFrEF),
lower discharge heart rate (HR) is known to be associated with better outcomes.
However, the effect of HR control on patient outcomes, and the demographic and …
lower discharge heart rate (HR) is known to be associated with better outcomes.
However, the effect of HR control on patient outcomes, and the demographic and …
Okechukwu Ogah
Aug 8, 2024, 3:18:51 AM8/8/24
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[PDF] Prognostic impact of beta‐blocker use by N‐terminal pro‐brain natriuretic peptide level in acute heart failure patients
SJ Kim, SH Ann, GM Park, YG Kim, S Park, SG Lee - ESC Heart Failure, 2024
Aims Both patients with heart failure (HF) with reduced ejection fraction (HFrEF) and
those with HF with preserved ejection fraction (HFpEF) present with elevated N‐
terminal pro‐brain natriuretic peptide (NT‐proBNP) and have multiple comorbidities; …
those with HF with preserved ejection fraction (HFpEF) present with elevated N‐
terminal pro‐brain natriuretic peptide (NT‐proBNP) and have multiple comorbidities; …
| | | |
[PDF] Evaluation of a nomogram model for predicting in-hospital mortality risk in patients with acute ST-elevation myocardial infarction and acute heart failure post-PCI
F Yu, Y Xu, J Peng - Scandinavian Cardiovascular Journal, 2024
Objectives This study aims to identify the risk factors contributing to in-hospital
mortality in patients with acute ST-elevation myocardial infarction (STEMI) who
develop acute heart failure (AHF) post-percutaneous coronary intervention (PCI) …
mortality in patients with acute ST-elevation myocardial infarction (STEMI) who
develop acute heart failure (AHF) post-percutaneous coronary intervention (PCI) …
| | | |
Role of sacubitril-valsartan in arrhythmic events and risk of sudden cardiac death in heart failure patients
EZ Golukhova, OI Gromova
Sacubitril-valsartan has been proven to reduce the risks of death and hospitalization
in patients with heart failure. The pathophysiological mechanisms of heart failure
progression and development of atrial and ventricular arrhythmias are largely similar …
in patients with heart failure. The pathophysiological mechanisms of heart failure
progression and development of atrial and ventricular arrhythmias are largely similar …
Okechukwu Ogah
Aug 10, 2024, 2:14:29 PM8/10/24
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[HTML] Empagliflozin combined with sacubitril/valsartan in hypertensive patients with heart failure: a retrospective study of efficacy and effect on blood pressure variability and …
Y Ma, W Li, Y Liu, L Li - American Journal of Translational Research, 2024
Objective: To evaluate the efficacy of empagliflozin combined with
sacubitril/valsartan in treating hypertensive patients with heart failure (HF), focusing
on its effects on blood pressure variability (BPV) and cardiac function. Methods: This …
sacubitril/valsartan in treating hypertensive patients with heart failure (HF), focusing
on its effects on blood pressure variability (BPV) and cardiac function. Methods: This …
| | | |
Determinants of invasive left atrial pressure in patients with atrial fibrillation
B Andrea, D Anna, C Angelica, S Enrico Guido… - European Heart Journal …, 2024
Aims Estimation of left ventricular (LV) filling pressures in patients with atrial
fibrillation (AF) is challenging due to lack of reliable parameters. This study
investigates the association between cardiac structure and function and invasive …
fibrillation (AF) is challenging due to lack of reliable parameters. This study
investigates the association between cardiac structure and function and invasive …
| | | |
[HTML] The effect of non-insulin-based insulin resistance indices on the prediction of recurrence in patients with atrial fibrillation undergoing radiofrequency catheter ablation
Y Luo, D Luo, G Yang, W Huang, Y Tang, B Xu, G He… - Cardiovascular Diabetology, 2024
Atrial fibrillation (AF) is acknowledged as a disease continuum. Despite catheter
ablation being recommended as a primary therapy for AF, the high recurrence rates
have tempered the initial enthusiasm. Insulin resistance (IR) has been established as …
ablation being recommended as a primary therapy for AF, the high recurrence rates
have tempered the initial enthusiasm. Insulin resistance (IR) has been established as …
| | | |
[PDF] The D‐HCM score, a new diagnostic tool for distinguishing hypertrophic cardiomyopathy from hypertensive cardiopathy
G Domain, M Biscond, N Dognin, C Strube, P Mondoly… - ESC Heart Failure, 2024
Aim The diagnosis of hypertrophic cardiomyopathy (HCM) with moderate
hypertrophy is challenging. Hypertensive heart disease (HHD) is the most common
differential diagnosis that mimics the LVH of HCM. The aim of this study was to …
hypertrophy is challenging. Hypertensive heart disease (HHD) is the most common
differential diagnosis that mimics the LVH of HCM. The aim of this study was to …
| | | |
[PDF] Patients with heart failure and reduced ejection fraction: The sub-analysis from the 3-year Coordinated Myocardial Infarction Care Program (KOS-MI) registry
M Mazur, A Kolarczyk-Haczyk, Ł Konarski, M Grajek… - Polish Heart Journal …, 2024
ABSTRACT Background: Coordinated Care Program after Myocardial Infarction
(KOS-MI) implemented in Poland has shown significant improvement of patient
prognosis, nationwide success, and international attention. A similar program and …
(KOS-MI) implemented in Poland has shown significant improvement of patient
prognosis, nationwide success, and international attention. A similar program and …
| | | |
[HTML] Septic cardioembolic stroke secondary to infective endocarditis in a young patient with rheumatic heart disease: a case report
HA Buque, E Namburete, DC Vaz, FJ Sebasteão… - Oxford Medical Case …, 2024
The risk of stroke due to infective endocarditis is particularly high during the first
week. Moreover, in low-resource settings where imaging access is limited, and
diagnostic pathways are inaccurate the risk further increases. In addition to antibiotic …
week. Moreover, in low-resource settings where imaging access is limited, and
diagnostic pathways are inaccurate the risk further increases. In addition to antibiotic …
Okechukwu Ogah
Aug 17, 2024, 8:04:07 AM8/17/24
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[HTML] Effects of SGLT2-Inhibitors on Comprehensive Geriatric Assessment, Biomarkers of Oxidative Stress, and Platelet Activation in Elderly Diabetic Patients with Heart …
M Magurno, V Cassano, F Maruca, CA Pastura… - International Journal of …, 2024
Background: Heart failure (HF) with preserved ejection fraction (HFpEF) represents a
major comorbidity in the elderly and is associated with cognitive impairment (CoI)
and type 2 diabetes mellitus (T2DM). In this context, there is an increase in oxidative …
major comorbidity in the elderly and is associated with cognitive impairment (CoI)
and type 2 diabetes mellitus (T2DM). In this context, there is an increase in oxidative …
| | | |
Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection Fraction: The AMETHYST Randomized Clinical Trial
DW Kitzman, AA Voors, RJ Mentz, GD Lewis, S Perl… - JAMA cardiology
Importance Elevated serum uric acid (SUA) level may contribute to endothelial
dysfunction; therefore, SUA is an attractive target for heart failure with preserved
ejection fraction (HFpEF). However, to the authors' knowledge, no prior randomized …
dysfunction; therefore, SUA is an attractive target for heart failure with preserved
ejection fraction (HFpEF). However, to the authors' knowledge, no prior randomized …
| | | |
The association of haemoglobin A1c variability with adverse outcomes in patients with atrial fibrillation prescribed anticoagulants
JY Huang, AP Cai, CTW Tsang, MZ Wu, WL Gu, R Guo… - European Journal of …, 2024
Aims The association of haemoglobin A1c (HbA1c) variability with the risk of adverse
outcomes in patients with atrial fibrillation (AF) prescribed anticoagulants remains
unclear. This study aimed to evaluate the association of HbA1c variability with the …
outcomes in patients with atrial fibrillation (AF) prescribed anticoagulants remains
unclear. This study aimed to evaluate the association of HbA1c variability with the …
| | | |
[HTML] Use and Benefit of Sacubitril/Valsartan in Elderly Patients with Heart Failure with Reduced Ejection Fraction
LN Roca, MC García, JB Germán, AJB Becerra… - Journal of Clinical Medicine, 2024
Background: Heart failure (HF) is a highly prevalent syndrome in elderly subjects.
Currently, multiple drugs have shown clinical benefits in patients with HF and
reduced ejection fraction (HFrEF). However, evidence is scarce in elderly patients …
Currently, multiple drugs have shown clinical benefits in patients with HF and
reduced ejection fraction (HFrEF). However, evidence is scarce in elderly patients …
| | | |
[PDF] Randomized Trials of Renal Denervation for Uncontrolled Hypertension: An Updated Meta‐Analysis
SH Mufarrih, NQ Qureshi, MS Khan, M Kazimuddin… - Journal of the American …, 2024
Background Despite optimal medical therapy, a significant proportion of patients'
blood pressure remains uncontrolled. Catheter‐based renal denervation (RDN) has
been proposed as a potential intervention for uncontrolled hypertension. We …
blood pressure remains uncontrolled. Catheter‐based renal denervation (RDN) has
been proposed as a potential intervention for uncontrolled hypertension. We …
Okechukwu Ogah
Aug 25, 2024, 12:05:42 PM8/25/24
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[HTML] A comprehensive insight from molecular docking and dynamics with clinical investigation on the impact of direct oral anticoagulants on atheroprotective protein in …
M Sudhan, V Janakiraman, SF Ahmad, SM Attia… - BMC Pharmacology and …, 2024
Direct oral anticoagulants (DOACs) have high potency against their therapeutic
target and are widely used in the treatment of atrial fibrillation (AF). Most DOACs are
often claimed to have adverse effects due to off-target inhibition of essential proteins …
target and are widely used in the treatment of atrial fibrillation (AF). Most DOACs are
often claimed to have adverse effects due to off-target inhibition of essential proteins …
| | | |
Adverse events associated with early initiation of Eplerenone in patients hospitalized for acute heart failure
M Kobayashi, A Yamashina, K Satomi, A Tezuka, S Ito… - International Journal of …, 2024
Background The guidelines recommend the initiation or up-titration of heart failure
(HF) treatments following an HF hospitalization; however, concerns about adverse
events may limit the use of mineralocorticoid receptor antagonists (MRAs). Patient …
(HF) treatments following an HF hospitalization; however, concerns about adverse
events may limit the use of mineralocorticoid receptor antagonists (MRAs). Patient …
eslam munshe
Aug 25, 2024, 10:34:36 PM8/25/24
to NIGERIAN CARDIAC SOCIETY
Dear ………. Warm
We are Abu Farha Medical Company,located in Jordan which
specializes in establishing cardiology and radiology centers.
1. Cath lab (catheterization laboratory) equipment
2. Cardiac surgery
3. Magnetic Resonance Imaging (MRI)
4. Computed Tomography (CT) imaging
5. Lithotripsy (breaking up stones)
6. X-rays
7. Ultrasound imaging
8. And other radiology equipment
We provide training and education for doctors, technicians,
nurses, and engineers, along with installation, warranty, and
development services.
We can send a team of doctors and bring permanent staff if
needed...
* Additionally, for an agreed amount, we offer specialized
technical support throughout the device's lifespan, including
ongoing training for medical staff to ensure optimal use of
new technology.
We have over 20 years of experience in equipping Cath Lab
departments, open-heart surgery rooms, and various imaging
devices such as MRI and CT scans, among others.
We operate in several countries, including: Jordan, Egypt,
Syria, Iraq, Yemen, Libya, Somalia, Uzbekistan, Bangladesh,
and Turkey
We also prepared a study to
establish a heart center
Please read it
Link to our channel for medical
devices
We are ready to answer your questions
You can request an online meeting to discuss the details of
the devices
Or a medical discussion with the company owner
Cardiologist Dr. Walid Abu Farha
https://whatsapp.com/channel/0029VajQGF665yDI3T07pn05
For any inquiries, contact me
Yazan Abu Farha
Director
AbuFarha Medical Supplies
* 📠 Telfax: +962 6 553 8426
* 📱 💬 Mobile/WhatsApp: +962 79 974 1318
🌐 Email:Ya...@abufarhamedical.com
* 🌐 Email: sa...@abufarhamedical.com
https://abufarhamedical.com
eslam munshe
Aug 25, 2024, 10:37:12 PM8/25/24
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Okechukwu Ogah
Aug 29, 2024, 8:34:27 AM8/29/24
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[PDF] Differences in heart failure with preserved ejection fraction management between care providers: an international survey
F Guidetti, CIS Giraldo, A Shchendrygina, K Kida… - European Journal of Heart …, 2024
Aims Heart failure (HF) with preserved ejection fraction (HFpEF) is characterized by
growing incidence and poor outcomes. A large majority of HFpEF patients are cared
by non‐cardiologists. The availability of sodium–glucose cotransporter 2 inhibitors …
growing incidence and poor outcomes. A large majority of HFpEF patients are cared
by non‐cardiologists. The availability of sodium–glucose cotransporter 2 inhibitors …
| | | |
[HTML] Left ventricular reverse remodeling after combined ARNI and SGLT2 therapy in heart failure patients with reduced or mildly reduced ejection fraction
M Correale, D D'Alessandro, L Tricarico, V Ceci… - IJC Heart & Vasculature, 2024
Background Cardiac remodeling is an adverse phenomenon linked to heart failure
(HF) progression. Cardiac remodeling could represent the real therapeutic goal in
the treatment of patients with HF and reduced ejection fraction (HFrEF), being …
(HF) progression. Cardiac remodeling could represent the real therapeutic goal in
the treatment of patients with HF and reduced ejection fraction (HFrEF), being …
| | | |
[HTML] Anti-atrial Fibrillatory and Cardiorenal Protective Effects of the Combination of Valsartan and Cilnidipine in Dahl Salt-Sensitive Rats
E Harada, K Sugino, A Takahara - Biological and Pharmaceutical Bulletin, 2024
The current study aimed to investigate the anti-atrial fibrillatory (AF) effects of a
combination of valsartan and a calcium channel blocker (cilnidipine or amlodipine) in
Dahl salt-sensitive (Dahl S) rats. Seven-week-old male Dahl S rats were fed an 8 …
combination of valsartan and a calcium channel blocker (cilnidipine or amlodipine) in
Dahl salt-sensitive (Dahl S) rats. Seven-week-old male Dahl S rats were fed an 8 …
| | | |
Inflammatory Biomarkers in Patients With Type 2 Diabetes Mellitus and Heart Failure With Preserved Ejection Faction
TS Sveklina, SB Shustov, SN Kolyubaeva, AN Kuchmin… - Kardiologiia, 2024
Aim To verify the relationship between gene polymorphisms of tumor necrosis factor
alpha (TNF-α) and interleukin-6 (IL-6) with inflammation markers and codependent
metabolic variables in patients with type 2 diabetes mellitus and chronic heart failure …
alpha (TNF-α) and interleukin-6 (IL-6) with inflammation markers and codependent
metabolic variables in patients with type 2 diabetes mellitus and chronic heart failure …
| | | |
Impact of natriuresis on worsening renal function during episodes of acute heart failure
PC Pérez, I Fernández-Herrero, JJ Broseta… - Revista Española de …, 2024
Introduction and objectives: Worsening renal function (WRF) is a frequent
complication in acute heart failure (AHF) with a controversial prognostic value. We
aimed to study the usefulness of natriuresis to evaluate WRF. Methods: We …
complication in acute heart failure (AHF) with a controversial prognostic value. We
aimed to study the usefulness of natriuresis to evaluate WRF. Methods: We …
| | | |
[PDF] Evaluation of a nomogram model for predicting in-hospital mortality risk in patients with acute ST-elevation myocardial infarction and acute heart failure post-PCI
F Yu, Y Xu, J Peng - Scandinavian Cardiovascular Journal, 2024
Objectives This study aims to identify the risk factors contributing to in-hospital
mortality in patients with acute ST-elevation myocardial infarction (STEMI) who
develop acute heart failure (AHF) post-percutaneous coronary intervention (PCI) …
mortality in patients with acute ST-elevation myocardial infarction (STEMI) who
develop acute heart failure (AHF) post-percutaneous coronary intervention (PCI) …
| | | |
[PDF] Patients with heart failure and reduced ejection fraction: The sub-analysis from the 3-year Coordinated Myocardial Infarction Care Program (KOS-MI) registry
M Mazur, A Kolarczyk-Haczyk, Ł Konarski, M Grajek… - Polish Heart Journal …, 2024
ABSTRACT Background: Coordinated Care Program after Myocardial Infarction
(KOS-MI) implemented in Poland has shown significant improvement of patient
prognosis, nationwide success, and international attention. A similar program and …
(KOS-MI) implemented in Poland has shown significant improvement of patient
prognosis, nationwide success, and international attention. A similar program and …
| | | |
[HTML] Exploring the Association Between Heart Rate Control and Rehospitalization: A Real-World Analysis of Patients Hospitalized with Heart Failure with Reduced Ejection …
FV Mody, RK Goyal, M Ajmera, KL Davis, AN Amin - Drugs-Real World Outcomes, 2024
Background In patients with heart failure with reduced ejection fraction (HFrEF),
lower discharge heart rate (HR) is known to be associated with better outcomes.
However, the effect of HR control on patient outcomes, and the demographic and …
lower discharge heart rate (HR) is known to be associated with better outcomes.
However, the effect of HR control on patient outcomes, and the demographic and …
| | | |
Protocol for a randomized controlled trial of intensive blood pressure control on cardiovascular risk reduction in patients with atrial fibrillation: rationale and design of …
C Jiang, Z Wang, X Du, Y Wang, M Gao, Z Jia, Z Chai… - American heart journal
Background Co-morbid hypertension is strong predictor of adverse cardiovascular
(CV) outcomes in patients with atrial fibrillation (AF) but the optimal target for blood
pressure (BP) control in this patient population has not been clearly defined. Method …
(CV) outcomes in patients with atrial fibrillation (AF) but the optimal target for blood
pressure (BP) control in this patient population has not been clearly defined. Method …
Okechukwu Ogah
Sep 2, 2024, 5:43:08 PM9/2/24
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[PDF] Predictive value of NT pro BNP for new-onset atrial fibrillation in heart failure and preserved ejection fraction
X Liu, S Chen, H Pan, Z Zhang, Y Wang, Y Jiang, M Wu… - ESC Heart Failure
Aims The prognostic significance of N-terminal pro B-type natriuretic peptide (NT-
proBNP) in heart failure with preserved ejection fraction (HFpEF) has been well
established. HFpEF and atrial fibrillation (AF) commonly coexist, and each …
proBNP) in heart failure with preserved ejection fraction (HFpEF) has been well
established. HFpEF and atrial fibrillation (AF) commonly coexist, and each …
| | | |
[PDF] The effects of SGLT-2 inhibitors on echocardiographic indices and antioxidative properties in patients with heart failure with reduced ejection fraction and diabetes …
MD SAVCILIOGLU, IV Duzen, SY Tuluce… - European Review for …, 2024
OBJECTIVE: Sodium-glucose co-transporter-2 inhibitors (SGLT-2i) are a new class
of drugs that lower blood glucose and reduce mortality in heart failure patients with
reduced ejection fraction (HFrEF). They also have antioxidant effects. The exact …
of drugs that lower blood glucose and reduce mortality in heart failure patients with
reduced ejection fraction (HFrEF). They also have antioxidant effects. The exact …
| | | |
[HTML] In-hospital initiation of angiotensin receptor–neprilysin inhibition in acute heart failure: the PREMIER trial
A Tanaka, K Kida, Y Matsue, T Imai, S Suwa, I Taguchi… - European Heart Journal, 2024
Abstract Background and Aims The efficacy and safety of early sacubitril/valsartan
(Sac/Val) initiation after acute heart failure (AHF) has not been demonstrated outside
North America. The present study aimed to evaluate the effect of in-hospital Sac/Val …
(Sac/Val) initiation after acute heart failure (AHF) has not been demonstrated outside
North America. The present study aimed to evaluate the effect of in-hospital Sac/Val …
| | | |
Natriuretic peptides, kidney function and clinical outcomes in heart failure with preserved ejection fraction
BL Neuen, M Vaduganathan, BL Claggett, I Beldhuis… - JACC: Heart Failure, 2024
Background N-terminal pro-B-type natriuretic peptides (NT-proBNP) are guideline-
recommended biomarkers for risk stratification in patients with heart failure. However,
NT-proBNP levels are often elevated in chronic kidney disease, introducing …
recommended biomarkers for risk stratification in patients with heart failure. However,
NT-proBNP levels are often elevated in chronic kidney disease, introducing …
| | | |
Double-chambered left ventricle in a patient with Wolff–Parkinson–White syndrome: A case report
M Busco, FA Gabrielli, G Bencardino, P Notarstefano… - Progress in Pediatric …, 2024
Congenital heart diseases like non-compaction cardiomyopathy, congenital left
ventricular diverticulum and aneurysm are potentially triggers of arrhythmias. Any
condition affecting the correct embryological development of the atrioventricular …
ventricular diverticulum and aneurysm are potentially triggers of arrhythmias. Any
condition affecting the correct embryological development of the atrioventricular …
| | | |
Inhibition of myeloperoxidase to treat left ventricular dysfunction in non-ischaemic cardiomyopathy
S Geissen, S Braumann, J Adler, FS Nettersheim… - European journal of heart failure
Aims Non-ischaemic cardiomyopathy (NICMP), an incurable disease terminating in
systolic heart failure (heart failure with reduced ejection fraction [HFrEF]), causes
immune activation, however anti-inflammatory treatment strategies so far have failed …
systolic heart failure (heart failure with reduced ejection fraction [HFrEF]), causes
immune activation, however anti-inflammatory treatment strategies so far have failed …
Okechukwu Ogah
Sep 5, 2024, 1:53:24 AM9/5/24
to nigerian-car...@googlegroups.com
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To: <osoga...@gmail.com>
From: Google Scholar Alerts <scholarale...@google.com>
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Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease
MS Cho, DY Kang, JM Ahn, SC Yun, YS Oh, CH Lee… - New England Journal of …, 2024
Background Despite consistent recommendations from clinical guidelines, data from
randomized trials on a long-term antithrombotic treatment strategy for patients with
atrial fibrillation and stable coronary artery disease are still lacking. Methods We …
randomized trials on a long-term antithrombotic treatment strategy for patients with
atrial fibrillation and stable coronary artery disease are still lacking. Methods We …
| | | |
[PDF] Burst steroid therapy for acute heart failure: The CORTAHF randomized, open‐label, pilot trial
G Cotter, BA Davison, Y Freund, AA Voors, C Edwards… - European Journal of Heart Failure
Aims Burst steroid therapy, effective in acute respiratory diseases, may benefit
patients with acute heart failure (AHF) in whom inflammatory activation is associated
with adverse outcomes. Methods and results CORTAHF assessed whether burst …
patients with acute heart failure (AHF) in whom inflammatory activation is associated
with adverse outcomes. Methods and results CORTAHF assessed whether burst …
| | | |
[HTML] Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis
PS Jhund, A Talebi, AD Henderson, BL Claggett… - The Lancet, 2024
Summary Background Mineralocorticoid receptor antagonists (MRAs) reduce
hospitalisations and death in patients with heart failure and reduced ejection fraction
(HFrEF), but the benefit in patients with heart failure and mildly reduced ejection …
hospitalisations and death in patients with heart failure and reduced ejection fraction
(HFrEF), but the benefit in patients with heart failure and mildly reduced ejection …
| | | |
Beta‐blocker use and outcomes in patients with heart failure and mildly reduced and preserved ejection fraction
S Matsumoto, AD Henderson, L Shen, T Kondo… - European Journal of Heart Failure
Aims In the absence of randomized trial evidence, we performed a large
observational analysis of the association between beta‐blocker (BB) use and clinical
outcomes in patients with heart failure (HF) and mildly reduced (HFmrEF) and …
observational analysis of the association between beta‐blocker (BB) use and clinical
outcomes in patients with heart failure (HF) and mildly reduced (HFmrEF) and …
| | | |
Sacubitril/valsartan reduces incident anaemia and iron therapy utilization in heart failure: The PARAGON‐HF trial
H Lu, BL Claggett, M Packer, MA Pfeffer, CSP Lam… - European Journal of Heart …, 2024
Aims Renin–angiotensin system inhibitors (RASi) have been shown to lower
haemoglobin levels, potentially related to reductions in erythropoietin levels and
haematopoiesis. We examined whether sacubitril/valsartan might attenuate this …
haemoglobin levels, potentially related to reductions in erythropoietin levels and
haematopoiesis. We examined whether sacubitril/valsartan might attenuate this …
Okechukwu Ogah
Sep 5, 2024, 11:58:32 PM9/5/24
to nigerian-car...@googlegroups.com
[HTML] Clinical characteristics and prognostic impact of atrial fibrillation among older patients with heart failure with preserved ejection fraction hospitalized for acute heart …
G De Matteis, ML Burzo, A Serra, DA Della Polla… - Internal and Emergency …, 2024
Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are
often coexisting conditions, but their interrelationship has not yet been clarified. This
study investigated the clinical characteristics and prognostic impact of AF among …
often coexisting conditions, but their interrelationship has not yet been clarified. This
study investigated the clinical characteristics and prognostic impact of AF among …
| | | |
[PDF] Bromocriptine treatment and outcomes in peripartum cardiomyopathy: the EORP PPCM registry
P van der Meer, B van Essen, C Viljoen, M Böhm… - European Heart Journal, 2024
Abstract Background and Aims Peripartum cardiomyopathy (PPCM) remains a
serious threat to maternal health around the world. While bromocriptine, in addition
to standard treatment for heart failure, presents a promising pathophysiology-based …
serious threat to maternal health around the world. While bromocriptine, in addition
to standard treatment for heart failure, presents a promising pathophysiology-based …
| | | |
[PDF] Apixaban, edoxaban and rivaroxaban but not dabigatran are associated with higher mortality compared to vitamin‐K antagonists: A retrospective German claims data …
C Engelbertz, U Marschall, J Feld, L Makowski… - Journal of Internal Medicine, 2024
Abstract Background Vitamin‐K antagonists (VKAs) have widely been replaced by
non‐VKA oral anticoagulants (NOACs). This includes Austria, Germany and
Switzerland, where as VKA, instead of warfarin, the much longer‐acting …
non‐VKA oral anticoagulants (NOACs). This includes Austria, Germany and
Switzerland, where as VKA, instead of warfarin, the much longer‐acting …
| | | |
[HTML] Effectiveness and safety of non-vitamin K antagonist oral anticoagulants in low-weight patients with atrial fibrillation
KH Chen, YY Hsu, CY Chou, CC Hsu, SL Chang… - Journal of Thrombosis and …, 2024
It remains unclear whether non-vitamin K antagonist oral anticoagulants (NOACs)
are more effective and safer than warfarin in low-weight patients with atrial fibrillation
(AF). Here, we retrospectively compared the effectiveness and safety of NOACs with …
are more effective and safer than warfarin in low-weight patients with atrial fibrillation
(AF). Here, we retrospectively compared the effectiveness and safety of NOACs with …
| | | |
[PDF] Anxiety, depression and their correlates among patients with acute heart failure in South Western, Nigeria
O Adebayo, A Aje, O Oladele, OS Ogah, A Adebiyi… - Ibom Medical Journal, 2024
Introduction: Psychological distress in heart failure has been relatively neglected by
researchers and practitioners, and early detection and treatment may improve the
prognosis and patient's quality of life. This study sought to assess psychological …
researchers and practitioners, and early detection and treatment may improve the
prognosis and patient's quality of life. This study sought to assess psychological …
| | | |
[HTML] Lipid control and stroke risk in atrial fibrillation patients treated with direct oral anticoagulants and statins
B Ip, T Yip, T Hung, TF Yam, C Yeung, H Ko, G Wong… - European stroke journal, 2024
Introduction: The risk of ischemic stroke and intracerebral hemorrhage (ICH) with
intensive lipid control by statins among patients with atrial fibrillation (AF) who
require direct oral anticoagulants (DOAC) is unclear. We aimed to determine the …
intensive lipid control by statins among patients with atrial fibrillation (AF) who
require direct oral anticoagulants (DOAC) is unclear. We aimed to determine the …
| | | |
Finerenone in Heart Failure and Chronic Kidney Disease with Type 2 Diabetes: the FINE-HEART pooled analysis of cardiovascular, kidney, and mortality outcomes
M Vaduganathan, G Filippatos, BL Claggett, AS Desai… - Nature Medicine, 2024
Cardiovascular-kidney-metabolic syndrome is an emerging entity that connects
cardiovascular diseases, chronic kidney disease, and diabetes. The non-steroidal
mineralocorticoid receptor antagonist, finerenone, has been studied in three …
cardiovascular diseases, chronic kidney disease, and diabetes. The non-steroidal
mineralocorticoid receptor antagonist, finerenone, has been studied in three …
| | | |
Why Has it Been Challenging to Modify Kidney Disease Progression in Patients With Heart Failure?
M Vaduganathan, BL Neuen, F McCausland, PS Jhund… - Journal of the American …, 2024
Chronic kidney disease (CKD) has emerged as a common comorbid condition in
heart failure (HF) 1 that increases in prevalence with duration and severity of HF and
has a substantial impact on the prognosis and clinical management of HF. Kidney …
heart failure (HF) 1 that increases in prevalence with duration and severity of HF and
has a substantial impact on the prognosis and clinical management of HF. Kidney …
| | | |
[HTML] Prospective Pakistan Registry of Echocardiographic Screening in Asymptomatic Pregnant Women
S Bhatti, S Naz, S Gurmani, H Yasmin, U Atif, M Karim… - JACC: Advances, 2024
Background Cardiovascular diseases are the primary cause of nonobstetric
morbidity and mortality in pregnant women worldwide. Pakistan's high maternal and
neonatal mortality rates underscore the need for effective screening protocols to …
morbidity and mortality in pregnant women worldwide. Pakistan's high maternal and
neonatal mortality rates underscore the need for effective screening protocols to …
Okechukwu Ogah
Sep 7, 2024, 12:02:31 AM9/7/24
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[PDF] Association of Systemic Inflammation Level on Admission with Total and Cardiovascular‑Specific Death in Heart Failure with Preserved Ejection Fraction: A Large …
W Lai, X Zhao, Z Gao, H Huang, D Huang, Y Zhou… - Journal of Inflammation …, 2024
Purpose Heart failure with preserved ejection fraction (HFpEF) is inherently a
complex inflammatory syndrome, and heightened inflammation is strongly
associated with an increased risk of death. However, the association of systemic …
complex inflammatory syndrome, and heightened inflammation is strongly
associated with an increased risk of death. However, the association of systemic …
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Factors Associated With Sacubitril/Valsartan Continuation and the Methods of Combining Heart Failure Medications in Patients With Heart Failure
E Iwasaki, N Kohyama, M Inamoto, M Nagao, T Sunaga… - Annals of Pharmacotherapy, 2024
Background: Sacubitril/valsartan (SV) is recommended for patients with heart failure
(HF). In addition, a combination of 4 HF medications, including SV, is recommended
in patients with HF with reduced ejection fraction (HFrEF). However, evidence on the …
(HF). In addition, a combination of 4 HF medications, including SV, is recommended
in patients with HF with reduced ejection fraction (HFrEF). However, evidence on the …
| | | |
Letter by Weir Regarding Article,“Effects of Semaglutide on Symptoms, Function, and Quality of Life in Patients With Heart Failure With Preserved Ejection Fraction and …
RAP Weir - Circulation, 2024
Kosiborod MN, Verma S, Borlaug BA, Butler J, Davies MJ, Jon Jensen T, Rasmussen
S, Erlang Marstrand P, Petrie MC, Shah SJ, et al; STEP-HFpEF Trial Committees and
Investigators. Effects of semaglutide on symptoms, function, and quality of life in …
S, Erlang Marstrand P, Petrie MC, Shah SJ, et al; STEP-HFpEF Trial Committees and
Investigators. Effects of semaglutide on symptoms, function, and quality of life in …
| | | |
Nurse‐led diuretic titration via a point‐of‐care urinary sodium sensor in patients with acute decompensated heart failure (EASY‐HF): A single‐centre, randomized …
E Meekers, P Martens, J Dauw, H Gruwez, S Dhont… - European Journal of Heart …, 2024
Aims Early evaluation of the natriuretic response is recommended to guide diuretic
therapy in acute decompensated heart failure (ADHF). However, its implementation
in daily practice is hampered by implementation barriers and increased time …
therapy in acute decompensated heart failure (ADHF). However, its implementation
in daily practice is hampered by implementation barriers and increased time …
| | | |
Response by Kosiborod et al to Letter Regarding Article,“Effects of Semaglutide on Symptoms, Function, and Quality of Life in Patients With Heart Failure With …
MN Kosiborod, MC Petrie, BA Borlaug - Circulation, 2024
Kosiborod MN, Verma S, Borlaug BA, Butler J, Davies MJ, Jensen TJ, Rasmussen S,
Marstrand PE, Petrie MC, Shah SJ, et al; STEP-HFpEF Trial Committees and
Investigators. Effects of semaglutide on symptoms, function, and quality of life in …
Marstrand PE, Petrie MC, Shah SJ, et al; STEP-HFpEF Trial Committees and
Investigators. Effects of semaglutide on symptoms, function, and quality of life in …
Okechukwu Ogah
Sep 10, 2024, 4:45:43 AM9/10/24
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[PDF] The Role of Epicardial Adipose Tissue-Derived Proteins in Heart Failure with Preserved Ejection Fraction and Atrial Fibrillation: A Bioinformatics Analysis
K Huang, J Lu, Q Li, C Wang, S Ding, X Xu, L Han - Journal of Inflammation Research, 2024
Background The accumulation of epicardial adipose tissue (EAT) is associated with
cardiometabolic risks and adverse outcomes in heart failure with preserved ejection
fraction (HFpEF) and atrial fibrillation (AF). This study aims to identify genes secreted …
cardiometabolic risks and adverse outcomes in heart failure with preserved ejection
fraction (HFpEF) and atrial fibrillation (AF). This study aims to identify genes secreted …
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[HTML] Vericiguat in heart failure with reduced ejection fraction patients on guideline-directed medical therapy: Insights from a 6-month real-world study
J Tian, M Dong, X Sun, X Jia, G Zhang, Y Zhang, Z Lin… - International Journal of …, 2024
Background Vericiguat has demonstrated efficacy in improving the prognosis of
patients with heart failure with reduced ejection fraction (HFrEF) following recent
clinical deterioration. However, its real-world impact on reducing N-terminal B-type …
patients with heart failure with reduced ejection fraction (HFrEF) following recent
clinical deterioration. However, its real-world impact on reducing N-terminal B-type …
| | | |
Serum Chloride and the Response to Acetazolamide in Patients With Acute Heart Failure and Volume Overload: A Post Hoc Analysis From the ADVOR Trial
J Van den Eynde, P Martens, J Dauw, P Nijst… - Circulation: Heart Failure, 2024
BACKGROUND: Chloride plays a crucial role in renal salt sensing. This study
investigates whether serum chloride is associated with clinical outcomes and
decongestive response to acetazolamide in patients with acute decompensated …
investigates whether serum chloride is associated with clinical outcomes and
decongestive response to acetazolamide in patients with acute decompensated …
| | | |
[HTML] HFpEF: Gender difference in sacubitril/valsartan response remains mystery
B Jancin
The explanation for the impressive clinical benefits of sacubitril/valsartan in women
with heart failure with preserved ejection fraction in the PARAGON-HF trial–but not in
the men–remains elusive, Jonathan W. Cunningham, MD, said at the joint scientific …
with heart failure with preserved ejection fraction in the PARAGON-HF trial–but not in
the men–remains elusive, Jonathan W. Cunningham, MD, said at the joint scientific …
| | | |
Peripartum Hypertensive Disease
PJ McGuire - Peripartum Care of the Pregnant Patient: A Question …
2. A 23-year-old G2P1 at 34 weeks presents to Labor and Delivery Triage
complaining of foamy urine. Her blood pressure is 152/95, and she is diagnosed with
preeclampsia. Which of the following is the MOST common cause of morbidity in …
complaining of foamy urine. Her blood pressure is 152/95, and she is diagnosed with
preeclampsia. Which of the following is the MOST common cause of morbidity in …
Okechukwu Ogah
Sep 13, 2024, 4:27:38 AM9/13/24
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fyi
[HTML] Abdominal obesity is associated with increased worsening renal function risk in patients with heart failure with preserved ejection fraction
Q Zhang, S Tai, S Zhou - BMC Cardiovascular Disorders, 2024
Background Worsening renal function (WRF) is a frequent comorbidity of heart failure
with preserved ejection fraction (HFpEF). However, its relationship with abdominal
obesity in terms of HFpEF remains unclear. This study aimed to evaluate the value of …
with preserved ejection fraction (HFpEF). However, its relationship with abdominal
obesity in terms of HFpEF remains unclear. This study aimed to evaluate the value of …
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Heart Failure With Preserved Ejection Fraction: From a Vascular Perspective
G Goudot, MD Gerhard-Herman - Circulation: Heart Failure, 2024
The findings of Baasen et al indicate that the benefit of a revascularization procedure
would apply to patients with symptomatic proximal PAD, following current guidelines,
rather than the presence of diffuse atherosclerosis with no hemodynamic impact on …
would apply to patients with symptomatic proximal PAD, following current guidelines,
rather than the presence of diffuse atherosclerosis with no hemodynamic impact on …
| | | |
[HTML] Prevalence of Cardiomyopathy in Patients with Type 1 Diabetes Mellitus
OD Fabila-de la Cruz, ES Luna-Avila… - Journal of Clinical Medicine, 2024
Background: Diabetic cardiac muscle disease or diabetic cardiomyopathy (DbCM)
comprises a set of myocardial lesions that are not associated with coronary
atherosclerosis or high blood pressure. It is characterized by fibrosis and …
comprises a set of myocardial lesions that are not associated with coronary
atherosclerosis or high blood pressure. It is characterized by fibrosis and …
Okechukwu Ogah
Sep 17, 2024, 2:04:01 PM9/17/24
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Incidence and risk factors of hypotension-related adverse events among Japanese patients with heart failure receiving sacubitril/valsartan or enalapril: Results from …
H Tsutsui, S Momomura, Y Saito, H Ito, K Yamamoto… - Journal of Cardiology, 2024
Abstract Background The PARALLEL-HF trial showed that treatment with
sacubitril/valsartan resulted in more symptomatic hypotension versus enalapril in
Japanese patients with heart failure (HF) and reduced ejection fraction, similar to …
sacubitril/valsartan resulted in more symptomatic hypotension versus enalapril in
Japanese patients with heart failure (HF) and reduced ejection fraction, similar to …
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[PDF] Comparison of mouse models of heart failure with reduced ejection fraction
NV Sayour, TG Gergely, B Váradi, VÉ Tóth, B Ágg… - ESC Heart Failure, 2024
Aims Heart failure with reduced ejection fraction (HFrEF) is a leading cause of death
worldwide; thus, therapeutic improvements are needed. In vivo preclinical models
are essential to identify molecular drug targets for future therapies. Transverse aortic …
worldwide; thus, therapeutic improvements are needed. In vivo preclinical models
are essential to identify molecular drug targets for future therapies. Transverse aortic …
| | | |
[HTML] Vericiguat in heart failure with reduced ejection fraction patients on guideline-directed medical therapy: Insights from a 6-month real-world study
J Tian, M Dong, X Sun, X Jia, G Zhang, Y Zhang, Z Lin… - International Journal of …, 2024
Background Vericiguat has demonstrated efficacy in improving the prognosis of
patients with heart failure with reduced ejection fraction (HFrEF) following recent
clinical deterioration. However, its real-world impact on reducing N-terminal B-type …
patients with heart failure with reduced ejection fraction (HFrEF) following recent
clinical deterioration. However, its real-world impact on reducing N-terminal B-type …
| | | |
Asundexian versus apixaban in patients with atrial fibrillation
JP Piccini, MR Patel, J Steffel, K Ferdinand… - New England Journal of …, 2024
Background Stroke prevention with direct-acting oral anticoagulant agents in patients
with atrial fibrillation confers a risk of bleeding and limits their use. Asundexian, an
activated factor XI (XIa) inhibitor, is an oral anticoagulant that may prevent strokes …
with atrial fibrillation confers a risk of bleeding and limits their use. Asundexian, an
activated factor XI (XIa) inhibitor, is an oral anticoagulant that may prevent strokes …
Okechukwu Ogah
Sep 23, 2024, 2:05:53 AM9/23/24
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[PDF] Timing of sodium–glucose cotransporter 2 inhibitor initiation and post‐discharge outcomes in acute heart failure with diabetes: A population‐based cohort study
CY Wu, BR Shah, A Sharma, Y Sheng, PP Liu, A Kopp… - European Journal of Heart …, 2024
Aims Results from randomized trials suggest benefit of sodium–glucose
cotransporter 2 (SGLT2) inhibitor initiation in clinically stable acute heart failure. We
aim to examine the real‐world effectiveness of early versus delayed post‐discharge …
cotransporter 2 (SGLT2) inhibitor initiation in clinically stable acute heart failure. We
aim to examine the real‐world effectiveness of early versus delayed post‐discharge …
Okechukwu Ogah
Sep 24, 2024, 1:37:31 AM9/24/24
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[PDF] Risk of Embolic Events in Patients with Chagasic Cardiomyopathy and Atrial Fibrillation Despite Antithrombotic Therapy: Is Anticoagulation Enough?
LE Echeverría, R Sánchez, AF Mantilla, MP Pizarro… - ARGENTINE JOURNAL OF
Background: Chagasic cardiomyopathy (CC) differs from other heart failure causes in
multiple aspects, highlighting the risk of systemic embolisms. However, few studies
have evaluated the risk of embolic events in anticoagulated patients with CC …
multiple aspects, highlighting the risk of systemic embolisms. However, few studies
have evaluated the risk of embolic events in anticoagulated patients with CC …
Okechukwu Ogah
Sep 29, 2024, 12:36:25 PM9/29/24
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Association of Aortic Stiffness with Heart Failure with Preserved Ejection Fraction: New Insights into the Ventriculoarterial Connection
J Bremerich, M Pradella - Radiology: Cardiothoracic Imaging, 2024
Maurice Pradella, MD, is an associate professor of radiology and deputy head of
cardiothoracic imaging at University Hospital Basel, Switzerland. He completed two
clinical fellowships (cardiothoracic and body imaging) and a research fellowship at …
cardiothoracic imaging at University Hospital Basel, Switzerland. He completed two
clinical fellowships (cardiothoracic and body imaging) and a research fellowship at …
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Is a Low-Dose Triple-Drug Combination Pill Protocol the Answer for Hypertension Control in Sub-Saharan Africa?
GA Mensah - JAMA, 2024
Hypertension, defined as a blood pressure of 140/90 mm Hg or higher, is the leading
preventable risk factor for cardiovascular death and all-cause mortality worldwide. 1,
2 The World Health Organization (WHO) estimates that nearly 1.3 billion adults aged …
preventable risk factor for cardiovascular death and all-cause mortality worldwide. 1,
2 The World Health Organization (WHO) estimates that nearly 1.3 billion adults aged …
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[PDF] Plasma renin activity as a marker for predicting the antihypertensive effect of switching to sacubitril/valsartan in treated hypertensive patients: Usefulness in daily …
T Horio, Y Iwashima, M Yoshiyama, D Fukuda, T Rai… - The Journal of Clinical …
The authors investigated the antihypertensive effect of sacubitril/valsartan (Sac/Val)
when switching from other drugs and assessed whether brain natriuretic peptide
(BNP) or plasma renin activity (PRA) before drug switching was a predictor of blood …
when switching from other drugs and assessed whether brain natriuretic peptide
(BNP) or plasma renin activity (PRA) before drug switching was a predictor of blood …
| | | |
[HTML] Lack of Anticoagulant Use in Patients with Atrial Fibrillation and Increased Risk of Thromboembolic Events According to Sex: Insights from a Multicentric Brazilian …
E Medei, R Moll-Bernardes, MVT Pinheiro, AS Sousa… - Arquivos Brasileiros de …, 2024
Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and its
presentation differs according to age and sex. Recent studies have revealed
differences in AF among various demographic groups, including the Latin American …
presentation differs according to age and sex. Recent studies have revealed
differences in AF among various demographic groups, including the Latin American …
| | | |
[PDF] Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the RELAX‐AHF‐2 trial
RM Inciardi, L Staal, B Davison, CM Lombardi… - European Journal of Heart …, 2024
Aims Acute heart failure (AHF) is a major cause of hospitalizations and death in the
elderly. However, elderly patients are often underrepresented in randomized clinical
trials. We analysed the impact of age on clinical outcomes and response to treatment …
elderly. However, elderly patients are often underrepresented in randomized clinical
trials. We analysed the impact of age on clinical outcomes and response to treatment …
Okechukwu Ogah
Oct 3, 2024, 3:57:18 PM10/3/24
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Date: Thu, 3 Oct 2024, 05:17
Subject: Recommended articles
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From: Google Scholar Alerts <scholarale...@google.com>
Date: Thu, 3 Oct 2024, 05:17
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[PDF] Real‐world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED–HEART study
U Kocabas, I Ergin, V Yavuz, C Altın, M Kaplan… - ESC Heart Failure, 2024
Aims We aimed to determine the use of sodium–glucose cotransporter 2 inhibitors
(SGLT2is) and to identify clinical factors associated with their use in patients with
heart failure (HF) in a real‐life setting. Methods Real‐world data on Empagliflozin …
(SGLT2is) and to identify clinical factors associated with their use in patients with
heart failure (HF) in a real‐life setting. Methods Real‐world data on Empagliflozin …
Okechukwu Ogah
Oct 4, 2024, 5:32:38 AM10/4/24
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Subject: Recommended articles
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From: Google Scholar Alerts <scholarale...@google.com>
Date: Fri, 4 Oct 2024, 08:44
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Cardiac Myosin Inhibition in Heart Failure With Normal and Supranormal Ejection Fraction: Primary Results of the EMBARK-HFpEF Trial
SJ Shah, M Rigolli, A Javidialsaadi, RB Patel, S Khadra… - JAMA cardiology, 2024
Importance Patients with heart failure with preserved ejection fraction (HFpEF) who
have left ventricular ejection fraction (LVEF) of 60% or greater have limited treatment
options. Objective To examine the effects of cardiac myosin inhibition with …
have left ventricular ejection fraction (LVEF) of 60% or greater have limited treatment
options. Objective To examine the effects of cardiac myosin inhibition with …
| | | |
[PDF] The Impact of Sacubitril/Valsartan on Heart Failure Patient with Reduced Left Ventricular Ejection Fraction: Single Center Retrospective Study in Saudi Arabia
S Al Raddadi, M Almutairi, K AlAamer, A Alsalman… - Drug, Healthcare and …, 2024
Background Sacubitril/valsartan (S/V) is used in managing heart failure with reduced
ejection fraction (HFrEF), reducing morbidity and mortality while improving symptoms
and prognosis. This study aims to evaluate the effectiveness of S/V in patients with …
ejection fraction (HFrEF), reducing morbidity and mortality while improving symptoms
and prognosis. This study aims to evaluate the effectiveness of S/V in patients with …
| | | |
[HTML] The effects of burst steroid therapy on short-term decongestion in acute heart failure patients with pro-inflammatory activation: a post-hoc analysis of the CORTAHF …
J Biegus, G Cotter, BA Davison, Y Freund, AA Voors… - Journal of Cardiac Failure, 2024
Background The effect of steroids on congestion in patients with acute heart failure
(AHF) is not known. Methods and results Patients with AHF, NT-proBNP> 1500
pg/mL, and high-sensitivity C-reactive protein (hsCRP)> 20 mg/L were randomized to …
(AHF) is not known. Methods and results Patients with AHF, NT-proBNP> 1500
pg/mL, and high-sensitivity C-reactive protein (hsCRP)> 20 mg/L were randomized to …
| | | |
[PDF] Finerenone Improves Outcomes in Patients with Heart Failure with Mildly Reduced or Preserved Ejection Fraction Irrespective of Age: A Prespecified Analysis of …
M Chimura, MC Petrie, M Schou, FA Martinez… - Circulation: Heart Failure, 2024
Background: Finerenone improves outcomes in patients with HF and mildly reduced
or preserved ejection fraction (HFmrHF/HFpEF). It is important to understand the
efficacy and safety of finerenone in these patients according to age. Methods: The …
or preserved ejection fraction (HFmrHF/HFpEF). It is important to understand the
efficacy and safety of finerenone in these patients according to age. Methods: The …
| | | |
[HTML] Prevalence of Cardiomyopathy in Patients with Type 1 Diabetes Mellitus
OD Fabila-de la Cruz, ES Luna-Avila… - Journal of Clinical Medicine, 2024
Background: Diabetic cardiac muscle disease or diabetic cardiomyopathy (DbCM)
comprises a set of myocardial lesions that are not associated with coronary
atherosclerosis or high blood pressure. It is characterized by fibrosis and …
comprises a set of myocardial lesions that are not associated with coronary
atherosclerosis or high blood pressure. It is characterized by fibrosis and …
| | | |
[PDF] Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure with Mildly Reduced and Preserved Ejection Fraction: a Prespecified …
KF Docherty, AD Henderson, PS Jhund, BL Claggett… - Circulation, 2024
Background: The effect of treatments for heart failure may vary among patients
according to left ventricular ejection fraction (LVEF). In the FINEARTS-HF, the
nonsteroidal MRA finerenone reduced the risk of cardiovascular death and total …
according to left ventricular ejection fraction (LVEF). In the FINEARTS-HF, the
nonsteroidal MRA finerenone reduced the risk of cardiovascular death and total …
Okechukwu Ogah
Oct 9, 2024, 6:08:00 AM10/9/24
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Subject: Recommended articles
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From: Google Scholar Alerts <scholarale...@google.com>
Date: Wed, Oct 9, 2024 at 8:56 AM
Subject: Recommended articles
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Epicardial Fat in Heart Failure with Preserved Ejection Fraction Compared with Reduced Ejection Fraction
GS Sidhu, SW Rabkin - Journal of Clinical Medicine, 2024
Background: The role of epicardial adipose tissue (EAT) in heart failure with
preserved ejection fraction (HFpEF) remains to be defined. Methods: A consecutive
series of outpatients with chronic heart failure—heart failure with reduced ejection …
preserved ejection fraction (HFpEF) remains to be defined. Methods: A consecutive
series of outpatients with chronic heart failure—heart failure with reduced ejection …
| | | |
[HTML] Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats
O Gawrys, Š Jíchová, M Miklovič, Z Husková… - Hypertension Research, 2024
All anthracyclines, including doxorubicin (DOXO), the most common and still
indispensable drug, exhibit cardiotoxicity with inherent risk of irreversible
cardiomyopathy leading to heart failure with reduced ejection fraction (HFrEF) …
indispensable drug, exhibit cardiotoxicity with inherent risk of irreversible
cardiomyopathy leading to heart failure with reduced ejection fraction (HFrEF) …
| | | |
[PDF] Plasma renin activity as a marker for predicting the antihypertensive effect of switching to sacubitril/valsartan in treated hypertensive patients: Usefulness in daily …
T Horio, Y Iwashima, M Yoshiyama, D Fukuda, T Rai… - The Journal of Clinical …
The authors investigated the antihypertensive effect of sacubitril/valsartan (Sac/Val)
when switching from other drugs and assessed whether brain natriuretic peptide
(BNP) or plasma renin activity (PRA) before drug switching was a predictor of blood …
when switching from other drugs and assessed whether brain natriuretic peptide
(BNP) or plasma renin activity (PRA) before drug switching was a predictor of blood …
| | | |
[HTML] Effect of impaired kidney function on outcomes and treatment effects of oral anticoagulant regimes in patients with atrial fibrillation in a real-world registry
C Salbach, BR Milles, H Hund, M Biener… - PloS one, 2024
Background The impact of impaired kidney function on outcomes and treatment
benefits of vitamin-K antagonists (VKA) versus direct oral anticoagulants (DOAC) in
patients with atrial fibrillation (AF) has insufficiently been investigated in randomized …
benefits of vitamin-K antagonists (VKA) versus direct oral anticoagulants (DOAC) in
patients with atrial fibrillation (AF) has insufficiently been investigated in randomized …
| | | |
Effect of eplerenon on heart failure in patients with paroxysmal Atrial Fibrillation and ejection fraction≥ 45%.
AM Ibrahim, AM Abdel Galil - Aswan University Medical Journal, 2024
Background: Atrial fibrillation (AF) is the commonest form of sustained arrhythmia; it
increases the risk of stroke, heart failure and mortality. So, preventing AF episodes is
needed. The aim of the present study was to investigate the effect of eplerenon …
increases the risk of stroke, heart failure and mortality. So, preventing AF episodes is
needed. The aim of the present study was to investigate the effect of eplerenon …
| | | |
2024 ESC Guidelines for the management of elevated blood pressure and hypertension: Developed by the task force on the management of elevated blood pressure …
JW McEvoy, CP McCarthy, RM Bruno, S Brouwers… - European Heart Journal
Disclaimer. The ESC Guidelines represent the views of the ESC and were produced
after careful consideration of the scientific and medical knowledge and the evidence
available at the time of their publication. The ESC is not responsible in the event of …
after careful consideration of the scientific and medical knowledge and the evidence
available at the time of their publication. The ESC is not responsible in the event of …
| | | |
[HTML] Diabetes-Induced Cardiomyopathy: Updates in Epidemiology, Prevention, and Management
EA Adeghate, S Mohsin, AB Amar, S AlAmry… - 2024
Diabetes mellitus (DM) is a condition of abnormal carbohydrate metabolism, leading
to persistent hyperglycemia. It is defined as a fasting blood glucose over 7.0 mmol/L,
a 2-hour plasma post-meal of 11.1 mmol/L, or HbA1C values over 6.5%(48 mmol/L) …
to persistent hyperglycemia. It is defined as a fasting blood glucose over 7.0 mmol/L,
a 2-hour plasma post-meal of 11.1 mmol/L, or HbA1C values over 6.5%(48 mmol/L) …
Okechukwu Ogah
Oct 10, 2024, 10:59:21 AM10/10/24
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[HTML] Leukocyte Indices as Markers of Inflammation and Predictors of Outcome in Heart Failure with Preserved Ejection Fraction
M Poledniczek, C Kronberger, L List, B Gregshammer… - Journal of Clinical Medicine, 2024
Background: The pathophysiology of heart failure (HF) with preserved ejection
fraction (HFpEF) is suggested to be influenced by inflammation. Leukocyte indices,
including the neutrophil–lymphocyte ratio (NLR), the monocyte–lymphocyte ratio …
fraction (HFpEF) is suggested to be influenced by inflammation. Leukocyte indices,
including the neutrophil–lymphocyte ratio (NLR), the monocyte–lymphocyte ratio …
| | | |
[PDF] Endoplasmic reticulum stress and expression of nitric oxide synthases in heart failure with preserved and with reduced ejection fraction—pilot study
K Momot, M Wojciechowska, K Krauz, K Czarzasta… - Cardiology Journal, 2024
Background: Unfolded Protein Response (UPR), endoplasmic reticulum (ER) stress,
and inducible nitric oxide synthase (iNOS) overexpression have been found to
influence heart failure with preserved ejection fraction (HFpEF) pathogenesis. Their …
and inducible nitric oxide synthase (iNOS) overexpression have been found to
influence heart failure with preserved ejection fraction (HFpEF) pathogenesis. Their …
| | | |
[PDF] Clinical impact of diastolic dysfunction and atrial fibrillation before and after initiating hemodialysis in patients with end-stage kidney disease
H Jeon, J Jeon, K Lee, J Kim, D Kim, JE Lee, W Huh… - Renal Failure, 2024
Background Diastolic dysfunction with left ventricular hypertrophy and myocardial
fibrosis is an important characteristic of uremic cardiomyopathy in end-stage kidney
disease (ESKD). Few studies explored the relationship between changes in diastolic …
fibrosis is an important characteristic of uremic cardiomyopathy in end-stage kidney
disease (ESKD). Few studies explored the relationship between changes in diastolic …
| | | |
[HTML] Phase III randomized clinical trial of efficacy and safety of amlodipine and candesartan cilexetil combination for hypertension treatment
MS Soh, K Won, JJ Kim, SY Lee, MS Hyon, HJ Youn… - Scientific Reports, 2024
Effective antihypertensive therapy is essential for achieving optimal blood pressure
(BP) control and reducing cardiovascular events. This double-blind, multicenter,
randomized trial aimed to compare the antihypertensive efficacy and safety of a …
(BP) control and reducing cardiovascular events. This double-blind, multicenter,
randomized trial aimed to compare the antihypertensive efficacy and safety of a …
| | | |
8 The role of heart rate measurement in heart failure patient with preserved ejection (HFpEF) presenting as acute condition: a single centre registry
Y Newary, CT Tjahjono, N Kurnianingsih, S Anjarwani… - 2024
Background Heart failure (HF) has become a major global burden on society, with a
40%–50% prevalence of acute heart failure among patients with Heart Failure with
Preserved Ejection Fraction (HFpEF). Due to readmission, heart failure patients in …
40%–50% prevalence of acute heart failure among patients with Heart Failure with
Preserved Ejection Fraction (HFpEF). Due to readmission, heart failure patients in …
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Weekly Journal Scan: Risk factors for recurrent ischaemic stroke in patients with atrial fibrillation on oral anticoagulation
L Galiuto, C Patrono - 2024
• Patients with atrial fibrillation (AF) face a substantial residual risk of ischaemic
stroke (IS) despite treatment with oral anticoagulants (OACs). The present study
aimed to evaluate the incidence of recurrent IS in such patients and to assess the risk …
stroke (IS) despite treatment with oral anticoagulants (OACs). The present study
aimed to evaluate the incidence of recurrent IS in such patients and to assess the risk …
Okechukwu Ogah
Oct 15, 2024, 1:56:57 AM10/15/24
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[PDF] Managing heart failure with reduced ejection fraction merged with myocardial infarction with non-obstructive coronary arteries: a case report
S Ikebe, M Yamamoto, M Ishii, E Yamamoto, K Tsujita - European Heart Journal-Case …, 2024
Background The concepts of myocardial infarction with non-obstructive coronary
arteries (MINOCA) are now widely accepted. Calcium channel blockers (CCBs) are
the first-line medication for coronary spastic angina (coronary spastic angina …
arteries (MINOCA) are now widely accepted. Calcium channel blockers (CCBs) are
the first-line medication for coronary spastic angina (coronary spastic angina …
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[HTML] Lack of Anticoagulant Use in Patients with Atrial Fibrillation and Increased Risk of Thromboembolic Events According to Sex: Insights from a Multicentric Brazilian …
E Medei, R Moll-Bernardes, MVT Pinheiro, AS Sousa… - Arquivos Brasileiros de …, 2024
Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and its
presentation differs according to age and sex. Recent studies have revealed
differences in AF among various demographic groups, including the Latin American …
presentation differs according to age and sex. Recent studies have revealed
differences in AF among various demographic groups, including the Latin American …
Okechukwu Ogah
Oct 20, 2024, 6:47:33 PM10/20/24
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fyi
[HTML] Cardiac structural and functional changes in OSAHS patients with heart failure with preserved ejection fraction and atrial fibrillation
H Wei, Y Luo, C Wei, H Liao, F Nong - BMC Cardiovascular Disorders, 2024
Objective To explore the cardiac structural and functional changes in obstructive
sleep apnea-hypopnea syndrome (OSAHS) patients with heart failure with preserved
ejection fraction (HFpEF) and atrial fibrillation (AF). Methods This retrospective study …
sleep apnea-hypopnea syndrome (OSAHS) patients with heart failure with preserved
ejection fraction (HFpEF) and atrial fibrillation (AF). Methods This retrospective study …
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[HTML] Valsartan/Sacubitril induced isolated angioedema of uvula: a case report.
MA Nazzal, A Iter, AQ Dawabsheh, MA Bsharat - Heliyon, 2024
Objective To report a case of drug-induced isolated angioedema secondary to the
use of Entresto (Valsartan/Sacubitril). Case Summary A 75-year-old White man
presented with swelling of the uvula with a normal tongue shape and gradual onset …
use of Entresto (Valsartan/Sacubitril). Case Summary A 75-year-old White man
presented with swelling of the uvula with a normal tongue shape and gradual onset …
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[PDF] Association Between Angiotensin Receptor-Neprilysin Inhibitor Use and Clinical Outcomes in Concurrent Heart Failure with Reduced Ejection Fraction and End-Stage …
MH Jung, DH Cho, J Choi, MN Kim, CJ Lee, JW Son… - medRxiv, 2024
Background: Although angiotensin receptor-neprilysin inhibitor (ARNI) therapy has
been shown to improve outcomes in heart failure with reduced ejection fraction
(HFrEF), its benefits in patients with end-stage renal disease (ESRD) on dialysis …
been shown to improve outcomes in heart failure with reduced ejection fraction
(HFrEF), its benefits in patients with end-stage renal disease (ESRD) on dialysis …
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[HTML] Effect of glycemic gap on prognosis and complications in vulnerable period of acute heart failure
L Zheng, W Zheng, M Zhang, B Li - Journal of Medical Biochemistry, 2024
Background: To investigate the effect of glycemic gap on the prognosis and
complications of heart failure in patients with acute heart failure. Methods: 100
patients with acute heart failure treated in our hospital from January 2022 to August …
complications of heart failure in patients with acute heart failure. Methods: 100
patients with acute heart failure treated in our hospital from January 2022 to August …
Okechukwu Ogah
Oct 20, 2024, 6:49:19 PM10/20/24
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[PDF] Hypertension and obesity independently drive hypertrophy and alter mitochondrial metabolism in a mouse model of heart failure with preserved ejection fraction
B Werbner, SL Stephens, D Stuart, TM Hotchkiss… - Physiological Reports, 2024
Heart failure with preserved ejection fraction (HFpEF) has recently emerged as an
insidiously and increasingly prevalent heart failure phenotype. HFpEF often occurs in
the context of hypertension and obesity and presents with diastolic dysfunction …
insidiously and increasingly prevalent heart failure phenotype. HFpEF often occurs in
the context of hypertension and obesity and presents with diastolic dysfunction …
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[HTML] Arrhythmias May Hide a Genetic Cardiomyopathy in Left Ventricular Hypertrabeculation in Children: A Single-Center Experience
I Battipaglia, N Cantarutti, M Cicenia, R Adorisio… - Children, 2024
Background. Left ventricular hypertrabeculation (LVHT) is a myocardial disorder with
different clinical manifestations, from total absence of symptoms to heart failure,
arrhythmias, sudden cardiac death (SCD), and thromboembolic events. It is …
different clinical manifestations, from total absence of symptoms to heart failure,
arrhythmias, sudden cardiac death (SCD), and thromboembolic events. It is …
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Global use of angiotensin receptor neprilysin inhibitor in heart failure and reduced, below normal and supranormal ejection fraction
Y Horiuchi, M Asami, K Yahagi, A Oshima, Y Gonda… - Heart and Vessels, 2024
Background The global use of angiotensin receptor neprilysin inhibitor (ARNI) in
clinical practice, especially in patients with heart failure and below-normal ejection
fraction (HFbnEF), has not been thoroughly evaluated. We aimed to investigate the …
clinical practice, especially in patients with heart failure and below-normal ejection
fraction (HFbnEF), has not been thoroughly evaluated. We aimed to investigate the …
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[HTML] Benefit of combination therapy with dapagliflozin and eplerenone on cardiac function and fibrosis in rats with non-diabetic chronic kidney disease
M Soulié, Y Stephan, M Durand, I Lima-Posada… - Scientific Reports, 2024
Patients with chronic kidney disease (CKD) are at a high risk of cardiovascular (CV)
complications. In these patients, sodium-glucose cotransporter-2 inhibitors (SGLT2i)
have been shown to reduce CV events. Mineralocorticoid receptor antagonists …
complications. In these patients, sodium-glucose cotransporter-2 inhibitors (SGLT2i)
have been shown to reduce CV events. Mineralocorticoid receptor antagonists …
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[HTML] The Challenge of Improving Outcomes After a Myocardial Infarction in Sub-Saharan Africa
E Ogola, M Jeilan - JACC: Advances
There is a growing burden of coronary artery disease (CAD) in sub-Saharan Africa
(SSA) which is bound to rise given the high prevalence and poor control of
cardiovascular risk factors such as hypertension. 1, 2 Herman and colleagues, in the …
(SSA) which is bound to rise given the high prevalence and poor control of
cardiovascular risk factors such as hypertension. 1, 2 Herman and colleagues, in the …
Okechukwu Ogah
Oct 28, 2024, 3:07:51 PM10/28/24
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Hemodynamic Insights From Provocative Testing in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction
I Landsteiner, A Ramesh, BQ Yang, GD Lewis - Journal of the American College of …, 2024
Some cardiovascular conditions have easily recognizable diagnostic test results and
clear temporal demarcation, such as electrocardiographic ST-segment elevations
coupled with an increase in troponin levels signaling ST-segment elevation …
clear temporal demarcation, such as electrocardiographic ST-segment elevations
coupled with an increase in troponin levels signaling ST-segment elevation …
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[HTML] Impact of diabetes mellitus on right ventricular dysfunction and ventricular interdependence in hypertensive patients with heart failure with reduced ejection fraction …
G Zhang, R Shi, XM Li, WF Yan, HY Xu, Y Li, YK Guo… - Cardiovascular Diabetology, 2024
Hypertension (HTN) and diabetes mellitus (DM) are two common comorbidities of
heart failure with reduced ejection fraction (HFrEF), each of which can cause right
ventricular (RV) dysfunction. The aim of this study was to investigate the impact of …
heart failure with reduced ejection fraction (HFrEF), each of which can cause right
ventricular (RV) dysfunction. The aim of this study was to investigate the impact of …
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[HTML] Sacubitril/valsartan improves diastolic left ventricular stiffness with increased titin phosphorylation via cGMP-PKG activation in diabetic mice
N Furukawa, H Matsui, H Sunaga, K Nagata… - Scientific Reports, 2024
Titin, a giant sarcomeric protein, regulates diastolic left ventricular (LV) passive
stiffness as a molecular spring and could be a therapeutic target for diastolic
dysfunction. Sacubitril/valsartan (Sac/Val), an angiotensin receptor neprilysin …
stiffness as a molecular spring and could be a therapeutic target for diastolic
dysfunction. Sacubitril/valsartan (Sac/Val), an angiotensin receptor neprilysin …
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Predictors of ischemic stroke in Chagas disease: Insights into mechanisms beyond cardiomyopathy severity
TAR Lage, MOC Rocha, JT Tupinambás, FA Botoni… - International Journal of …, 2024
Background Chagas disease is a risk factor for ischemic stroke, which causes high
mortality rates and significant disability. This study aims to determine the incidence
and risk factors for ischemic strokes in a large cohort of Chagas cardiomyopathy …
mortality rates and significant disability. This study aims to determine the incidence
and risk factors for ischemic strokes in a large cohort of Chagas cardiomyopathy …
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[HTML] Uric Acid and SGLT2 Inhibition With Empagliflozin in Heart Failure With Preserved Ejection Fraction: The EMPEROR-Preserved Trial
W Doehner, SD Anker, J Butler, F Zannad, G Filippatos… - JACC: Heart Failure, 2024
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors improve outcome in
patients with heart failure (HF) and reduce serum uric acid (SUA). The relevance of
this metabolic effect in patients with heart failure with preserved ejection fraction …
patients with heart failure (HF) and reduce serum uric acid (SUA). The relevance of
this metabolic effect in patients with heart failure with preserved ejection fraction …
Okechukwu Ogah
Nov 3, 2024, 2:46:17 PM11/3/24
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[HTML] Advancing cardiovascular outcomes with dapagliflozin and sacubitril in post-acute myocardial infarction heart failure and type 2 diabetes mellitus
DH Liu, XM Dong, WJ Long - World Journal of Clinical Cases, 2024
Coronary heart disease and type 2 diabetes mellitus (T2DM) often co-occur,
presenting substantial health risks, particularly following acute myocardial infarction
(AMI). While percutaneous coronary intervention (PCI) is a prevalent treatment …
presenting substantial health risks, particularly following acute myocardial infarction
(AMI). While percutaneous coronary intervention (PCI) is a prevalent treatment …
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Proteome profiling in patients with peripartum cardiomyopathy according to ethnicity a biomarker study on the EORP cohort
V Kodogo, C Viljoen, G Chakafana, J Hoevelmann… - European Heart Journal, 2024
Background Peripartum cardiomyopathy (PPCM) is a pregnancy-associated form of
heart failure, which occurs in previously healthy women towards the end of
pregnancy and in the first months postpartum. Previous reports showed a varying …
heart failure, which occurs in previously healthy women towards the end of
pregnancy and in the first months postpartum. Previous reports showed a varying …
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Baroreflex activation therapy in heart failure patients with reduced ejection fraction: a long-term follow up
D Wang, J Mueller-Leisse, HAK Hillmann, J Eiringhaus… - European Heart Journal, 2024
Introduction Heart failure with reduced ejection fraction (HFrEF) is a major public
health concern with substantial morbidity and mortality. Overactivation of the
sympathetic nervous system is a key pathophysiological process driving heart failure …
health concern with substantial morbidity and mortality. Overactivation of the
sympathetic nervous system is a key pathophysiological process driving heart failure …
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Extracranial systemic embolic events in patients with atrial fibrillation: an individual patient-level meta-analysis of 71 683 patients randomized to NOAC vs warfarin …
S Al Said, E Braunwald, MG Palazzolo, BJ Geller… - European Heart Journal, 2024
Abstract Background Atrial Fibrillation (AF) poses a significant risk for both ischemic
stroke and systemic embolic events (SEE). While the effectiveness of NOAC in
preventing ischemic stroke is well-established, there is a lack of detailed analyses …
stroke and systemic embolic events (SEE). While the effectiveness of NOAC in
preventing ischemic stroke is well-established, there is a lack of detailed analyses …
Okechukwu Ogah
Nov 4, 2024, 7:29:22 AM11/4/24
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[HTML] Predicting Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction by Using Machine Learning
CY Chang, CC Chen, ML Tsai, MJ Hsieh, TH Chen… - JACC: Asia, 2024
Background Few studies have incorporated echocardiography and laboratory data to
predict clinical outcomes in heart failure with preserved ejection fraction (HFpEF).
Objectives This study aimed to use machine learning to find predictors of heart failure …
predict clinical outcomes in heart failure with preserved ejection fraction (HFpEF).
Objectives This study aimed to use machine learning to find predictors of heart failure …
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[PDF] Pharmacotherapy sequencing strategies for patients with heart failure with reduced ejection fraction: a cost–utility analysis
MT Van, P Loewen, M Sadatsafavi, W Zhang… - CMAJ, 2024
Background Standard pharmacotherapy for patients with heart failure with reduced
ejection fraction (HFrEF) comprises “quadruple therapy” with a renin–angiotensin
system inhibitor, a β-blocker, a mineralocorticoid receptor antagonist, and a sodium …
ejection fraction (HFrEF) comprises “quadruple therapy” with a renin–angiotensin
system inhibitor, a β-blocker, a mineralocorticoid receptor antagonist, and a sodium …
Okechukwu Ogah
Nov 5, 2024, 10:09:10 PM11/5/24
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[HTML] Consequences of the Poor Anticoagulation Control of Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonists
A Sicras Mainar, J Salazar-Mendiguchía… - Journal of Clinical Medicine, 2024
Background: The prevention of thromboembolisms through anticoagulation and
heart rate control is crucial in managing non-valvular atrial fibrillation (NVAF). This
study aimed to analyze the consequences of poor anticoagulation control with …
heart rate control is crucial in managing non-valvular atrial fibrillation (NVAF). This
study aimed to analyze the consequences of poor anticoagulation control with …
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Echocardiographic evaluation of cardiac remodelling in a cohort of patients with heart failure and reduced ejection fraction treated with dapagliflozin
J Bonini, A Cantone, B Dal Passo, T Ballarini… - European Heart Journal, 2024
Background Several mechanisms have been proposed to explain SGLT2
inhibitors'(SGLT2i) beneficial effects in patients with heart failure (HF), but their exact
mode of action in this setting is not fully understood. Pivotal randomised clinical trials …
inhibitors'(SGLT2i) beneficial effects in patients with heart failure (HF), but their exact
mode of action in this setting is not fully understood. Pivotal randomised clinical trials …
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Dapagliflozin reduces epicardial adipose tissue in patients with heart failure with reduced ejection fraction and type 2 diabetes
M Alghamdi, J Singh, C Lang, I Mordi, F Khan - European Heart Journal, 2024
Introduction Epicardial adipose tissue (EAT) accumulation is associated with adverse
outcome in heart failure with preserved ejection fraction, however its role in HF with
reduced ejection fraction (HFrEF) is less clear. The relationship between EAT …
outcome in heart failure with preserved ejection fraction, however its role in HF with
reduced ejection fraction (HFrEF) is less clear. The relationship between EAT …
Okechukwu Ogah
Nov 9, 2024, 4:58:38 AM11/9/24
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[PDF] Clinical profiles and shortterm outcomes of women with peripartum and dilated cardiomyopathies
B Muhammad, NA Ishaq, KM Karaye - Global Cardiology, 2024
Background: We aimed to compare the clinical and sociodemographic
characteristics, rate of left ventricular reverse remodeling (LVRR), heart failure
hospitalization and allcause mortality of women with peripartum and dilated …
characteristics, rate of left ventricular reverse remodeling (LVRR), heart failure
hospitalization and allcause mortality of women with peripartum and dilated …
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Predictors of ischemic stroke in Chagas disease: Insights into mechanisms beyond cardiomyopathy severity
TAR Lage, MOC Rocha, JT Tupinambás, FA Botoni… - International Journal of …, 2024
Background Chagas disease is a risk factor for ischemic stroke, which causes high
mortality rates and significant disability. This study aims to determine the incidence
and risk factors for ischemic strokes in a large cohort of Chagas cardiomyopathy …
mortality rates and significant disability. This study aims to determine the incidence
and risk factors for ischemic strokes in a large cohort of Chagas cardiomyopathy …
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Reverse myocardial remodeling according to cardiac magnetic resonance imaging in patients with heart failure and atrial fibrillation receiving dapagliflozin
KM Saipudinova, TM Uskach, MA Sharia… - Cardiovascular Therapy and …, 2024
Aim. To determine the effect of dapagliflozin on cardiac remodeling parameters and
left ventricular mass according to cardiac magnetic resonance imaging in patients
with heart failure (HF) with reduced ejection fraction (EF) and atrial fibrillation (AF) …
left ventricular mass according to cardiac magnetic resonance imaging in patients
with heart failure (HF) with reduced ejection fraction (EF) and atrial fibrillation (AF) …
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[PDF] Beyond Anticoagulation: Limitations of Oral Anticoagulants in Preventing Stroke Recurrence in Atrial Fibrillation
J Seetge, B Cséke, ZN Karádi, E Bosnyák, L Szapáry - 2024
Background/Objectives: Despite the widespread use of oral anticoagulants (OACs),
acute ischemic stroke (AIS) remains a significant risk for patients with atrial fibrillation
(AF). The real-world effectiveness of OACs in preventing recurrent strokes …
acute ischemic stroke (AIS) remains a significant risk for patients with atrial fibrillation
(AF). The real-world effectiveness of OACs in preventing recurrent strokes …
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Elegibility for Sacubitril/Valsartan in italian clinical practice: insights from the OPTIMA-HF registry
S Paolillo, F Marzano, E Nardi, P Gargiulo, P Agostoni… - European Heart Journal, 2024
Abstract Background/Introduction Guidelines strongly recommend patients with heart
failure with reduced ejection fraction (HFrEF) be treated with multiple medications
proven to improve clinical outcomes, as tolerated. Among them, angiotensin receptor …
failure with reduced ejection fraction (HFrEF) be treated with multiple medications
proven to improve clinical outcomes, as tolerated. Among them, angiotensin receptor …
Okechukwu Ogah
Nov 12, 2024, 10:19:37 AM11/12/24
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[PDF] Triglyceride-glucose index is associated with heart failure with preserved ejection fraction in different metabolic states in patients with coronary heart disease
Z Li, X Fan, Y Liu, L Yu, Y He, L Li, S Gao, W Chen… - Frontiers in Endocrinology, 2024
Background The triglyceride-glucose (TyG) index is a surrogate indicator of insulin
resistance. Therefore, we aimed to determine the association between TyG index
and heart failure (HF) with preserved ejection fraction (HFpEF) in patients with …
resistance. Therefore, we aimed to determine the association between TyG index
and heart failure (HF) with preserved ejection fraction (HFpEF) in patients with …
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[HTML] Predictive Value of NT-proBNP, FGF21, Galectin-3 and Copeptin in Advanced Heart Failure in Patients with Preserved and Mildly Reduced Ejection Fraction and Type …
RD Ianos, M Iancu, C Pop, RL Lucaciu, AC Hangan… - Medicina, 2024
Background and Objectives: Heart failure (HF) is one of the most common initial
presentations of cardiovascular disease (CVD) in patients with type 2 diabetes
mellitus (T2DM). There are different cardiac biomarkers related to the …
presentations of cardiovascular disease (CVD) in patients with type 2 diabetes
mellitus (T2DM). There are different cardiac biomarkers related to the …
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[HTML] Comparison of Direct Oral Anticoagulants and Vitamin K Antagonists for Left Ventricular Thrombus: A Global Retrospective Study
Z Yao, Y Gue, GYH Lip - The American Journal of Medicine, 2024
Introduction Guidelines for managing left ventricular thrombus remain limited,
particularly when incorporating oral anticoagulants into dual antiplatelet therapy for
acute myocardial infarction. This study aims to assess the safety and efficacy of direct …
particularly when incorporating oral anticoagulants into dual antiplatelet therapy for
acute myocardial infarction. This study aims to assess the safety and efficacy of direct …
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Unraveling Marfan hearts: ultrastructural evidence for myocardial remodeling and cardiomyopathy
V Deleeuw, S D'hulst, A Demolder, F Steijns, M Renard… - European Heart Journal, 2024
Background Despite improved life expectancy for patients with Marfan syndrome
(MFS), significant morbidity and mortality persist. Although primarily attributed to
aortic dissection and rupture, recent studies highlight the emerging role of …
(MFS), significant morbidity and mortality persist. Although primarily attributed to
aortic dissection and rupture, recent studies highlight the emerging role of …
Okechukwu Ogah
Nov 15, 2024, 8:32:26 PM11/15/24
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[PDF] Malignant Ventricular Arrhythmia With Apical Biventricular Noncompaction
L Seth, V Patel, K Pandya, P Khyati - Cureus, 2024
Ventricular tachycardia (VT) arising from the right ventricle outflow tract is the most
common cause of VT in children with a structurally normal heart. It often presents as
a monomorphic VT that is usually amenable to ablation during an electrophysiology …
common cause of VT in children with a structurally normal heart. It often presents as
a monomorphic VT that is usually amenable to ablation during an electrophysiology …
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Assessing risk factors for peripartum quantified blood loss
B Kohl-Thomas, J Ehrig - Baylor University Medical Center Proceedings, 2024
Postpartum hemorrhage is increasing worldwide and in the US. 1 Identifying reliable
risk factors as well as definitions and measurement tools is essential. In the article
“Hemorrhage risk score and peripartum quantified blood loss,” Dr. Gutierrez-Disla et …
risk factors as well as definitions and measurement tools is essential. In the article
“Hemorrhage risk score and peripartum quantified blood loss,” Dr. Gutierrez-Disla et …
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Independent risk factors of ejection fraction deterioration post discharge in hospitalized heart failure patients with mildly reduced ejection fraction
MX Wu, X Peng, YL Zhu, ZC Liu, HB Huang, LL Zhang… - European Heart Journal, 2024
Background The identification of independent risk factors for left ventricular ejection
fraction (LVEF) deterioration is of clinical importance in patients diagnosed heart
failure with mildly reduced ejection fraction (HFmrEF). This study aimed to determine …
fraction (LVEF) deterioration is of clinical importance in patients diagnosed heart
failure with mildly reduced ejection fraction (HFmrEF). This study aimed to determine …
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Lead-In Parenteral Anticoagulation Prior to Direct Oral Anticoagulation for Cerebral Venous Thrombosis
TS Field, L Shu, DJ Kim, P Klein, JE Siegler… - Canadian Journal of …, 2024
Background: Growing evidence suggests that direct oral anticoagulants (DOACs)
may be suitable for cerebral venous thrombosis (CVT). The optimal strategy
regarding lead-in parenteral anticoagulation (PA) prior to DOAC is unknown …
may be suitable for cerebral venous thrombosis (CVT). The optimal strategy
regarding lead-in parenteral anticoagulation (PA) prior to DOAC is unknown …
Okechukwu Ogah
Nov 16, 2024, 9:30:56 PM11/16/24
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Heart Failure With Preserved Ejection Fraction—A Role for Invasive Hemodynamics
GC Fonarow, JE Udelson, CW Yancy - JAMA cardiology, 2024
Notable discoveries in the pathophysiology and treatment of heart failure with
preserved ejection fraction (HFpEF) now position this increasingly prevalent
phenotype of heart failure from enigmatic to clinically actionable with progressively …
preserved ejection fraction (HFpEF) now position this increasingly prevalent
phenotype of heart failure from enigmatic to clinically actionable with progressively …
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Prognostic Value of On-Treatment Left Ventricular Global Longitudinal Strain in Elderly Patients with Acute Heart Failure and Preserved Ejection Fraction
CH Tseng, WM Huang, SH Sung - Circulation, 2024
Background: Left ventricular global longitudinal strain (GLS) has been associated
with mortality and heart failure hospitalization (HFH) among subjects with chronic
heart failure, but not in patients with acute decompensated heart failure (ADHF). The …
with mortality and heart failure hospitalization (HFH) among subjects with chronic
heart failure, but not in patients with acute decompensated heart failure (ADHF). The …
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Efficacy of Empagliflozin in Heart Failure with Preserved Ejection Fraction is related to the presence of echocardiographic features of diastolic dysfunction in the …
A Coats, J Butler, H Zimmet, S Anker - Circulation, 2024
Introduction: Efficacy of SGLT2i empagliflozin in Heart Failure is seen across the
LVEF spectrum and in multiple clinical subgroups, with diverse mechanisms of
action. We hypothesized that objective echo evidence of diastolic dysfunction (DD) in …
LVEF spectrum and in multiple clinical subgroups, with diverse mechanisms of
action. We hypothesized that objective echo evidence of diastolic dysfunction (DD) in …
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Evaluation of Valsartan-Sacubitril for Heart Failure in Thi Qar Patients/Iraq
ZAH Manshad, NY Ghafil - Thi-Qar Medical Journal, 2024
Background: Heart failure (HF) is defined as any structural and/or functional
impairment of cardiac blood ejection raised from a structural or functional cardiac
disorders that impair the ability of the ventricle to fill with or eject blood, leads to a …
impairment of cardiac blood ejection raised from a structural or functional cardiac
disorders that impair the ability of the ventricle to fill with or eject blood, leads to a …
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Coronary artery bypass grafting vs. percutaneous coronary intervention in severe ischaemic cardiomyopathy: long-term survival
JE Bloom, S Vogrin, CM Reid, AE Ajani, DJ Clark… - European Heart Journal, 2024
Abstract Background and Aims The optimal revascularization strategy in patients with
ischaemic cardiomyopathy remains unclear with no contemporary randomized trial
data to guide clinical practice. This study aims to assess long-term survival in …
ischaemic cardiomyopathy remains unclear with no contemporary randomized trial
data to guide clinical practice. This study aims to assess long-term survival in …
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Association of the 2022 AHA/ACC/HFSA Heart Failure Staging and Cardiovascular and Kidney Outcomes in Patients with Diabetes and Kidney Disease: A Secondary …
A Odutayo, D Bhatt, V Sridhar, M Szarek, M Davies… - Circulation, 2024
Introduction: The 2022 AHA/ACC/HFSA heart failure (HF) classification newly
incorporates cardiac biomarkers to identify patients at risk of HF. Research Question:
Given shared risk factors between HF and other cardiorenal events, the HF stages …
incorporates cardiac biomarkers to identify patients at risk of HF. Research Question:
Given shared risk factors between HF and other cardiorenal events, the HF stages …
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Early changes in albuminuria and their interaction with eplerenone treatment in patients hospitalized for acute heart failure: findings from the EARLIER trial
A TEZUKA, M Kobayashi, A Yamashina, K Satomi, S Ito… - Circulation, 2024
Background: Patients hospitalized for acute heart failure (AHF) have high degrees of
congestion, which may be associated with albuminuria. Mineralocorticoid receptor
antagonists (MRAs) have natriuretic effects, possibly diminishing the degree of …
congestion, which may be associated with albuminuria. Mineralocorticoid receptor
antagonists (MRAs) have natriuretic effects, possibly diminishing the degree of …
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Neuro-specific biomarkers for risk assessment of ischemic stroke and death in patients with atrial fibrillation not receiving oral anticoagulation
J Aulin, K Sjolin, J Lindbäck, A Benz, J Eikelboom… - Circulation, 2024
Background: Biomarkers measured in plasma reflecting cardiorenal dysfunction and
inflammation are associated with clinical outcomes in atrial fibrillation (AF). We
recently showed an association between the plasma level of the neuronal biomarker …
inflammation are associated with clinical outcomes in atrial fibrillation (AF). We
recently showed an association between the plasma level of the neuronal biomarker …
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Systolic Blood Pressure in Heart Failure with Mildly Reduced or Preserved Ejection Fraction: A Pooled Participant-Level Analysis of 4 Large-Scale Trials
H Lu, T Kondo, B Claggett, M Vaduganathan, B Neuen… - Circulation, 2024
Background: Hypertension is common in patients with heart failure with preserved
ejection fraction (HFpEF). Treatment of systolic blood pressure (SBP) to a target< 130
mmHg in this population is often recommended based on general ACC/AHA and …
ejection fraction (HFpEF). Treatment of systolic blood pressure (SBP) to a target< 130
mmHg in this population is often recommended based on general ACC/AHA and …
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Elegibility for Sacubitril/Valsartan in italian clinical practice: insights from the OPTIMA-HF registry
S Paolillo, F Marzano, E Nardi, P Gargiulo, P Agostoni… - European Heart Journal, 2024
Abstract Background/Introduction Guidelines strongly recommend patients with heart
failure with reduced ejection fraction (HFrEF) be treated with multiple medications
proven to improve clinical outcomes, as tolerated. Among them, angiotensin receptor …
failure with reduced ejection fraction (HFrEF) be treated with multiple medications
proven to improve clinical outcomes, as tolerated. Among them, angiotensin receptor …
Okechukwu Ogah
Nov 24, 2024, 11:33:03 AM11/24/24
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[PDF] Characteristics, Predictors, and Clinical Outcomes in Heart Failure With Reduced Ejection Fraction According to a 1‐Year Left Ventricular Ejection Fraction Following …
CS Park, J Park, NY Bae, S Kwak, HM Choi, YE Yoon… - Journal of the American …, 2024
Background Optimal medical treatment can lead to improvement in left ventricular
ejection fraction (LVEF) in patients with heart failure with reduced EF (HFrEF). We
investigated the characteristics, predictors, and outcomes of HFrEF according to the …
ejection fraction (LVEF) in patients with heart failure with reduced EF (HFrEF). We
investigated the characteristics, predictors, and outcomes of HFrEF according to the …
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[PDF] Association Between Direct Oral Anticoagulant Score and Bleeding Events in Patients With Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: A …
Y Harano, M Yamamoto, T Shimura, M Okubo… - Journal of the American …, 2024
Background The Direct Oral Anticoagulant (DOAC) Score can predict bleeding risk in
patients with atrial fibrillation taking DOACs; however, it lacks external validation.
Therefore, this study aimed to assess the association between the DOAC Score and …
patients with atrial fibrillation taking DOACs; however, it lacks external validation.
Therefore, this study aimed to assess the association between the DOAC Score and …
| | | |
[HTML] Smartphone App for Improving Self-Awareness of Adherence to Edoxaban Treatment in Patients With Atrial Fibrillation (ADHERE-App Trial): Randomized Controlled …
M Yoon, JH Lee, IC Kim, JH Lee, MN Kim, HL Kim… - Journal of Medical Internet …, 2024
Background Adherence to oral anticoagulant therapy is essential to prevent ischemic
stroke in patients with atrial fibrillation (AF). Objective This study aimed to evaluate
whether smartphone app–based interventions improve medication adherence in …
stroke in patients with atrial fibrillation (AF). Objective This study aimed to evaluate
whether smartphone app–based interventions improve medication adherence in …
| | | |
[PDF] Impact of Sacubitril/Valsartan in Improving Home Time for Patients With Heart Failure
J Hiremath, SN Routray, P Hazra, D Gandotra… - Cureus, 2024
Home time, defined as time spent by the patient alive and out of any healthcare
institution, is an important patient-centric outcome for patients with cardiovascular
disease. Home time is recognized as a crucial measure of recovery post …
institution, is an important patient-centric outcome for patients with cardiovascular
disease. Home time is recognized as a crucial measure of recovery post …
| | | |
The impact of the 2022 definition of pulmonary hypertension on long-term clinical outcomes in patients with heart failure with preserved ejection fraction
F Sera, T Ohtani, M Seo, T Hayashi, M Yano… - European Heart Journal, 2024
Abstract@ Backgrounds: In recent years, the definitions of pulmonary hypertension
(PH) have been revised for early diagnosis and risk stratification of patients with PH.
Using the 2015 definitions, the development of a precapillary component of PH in …
(PH) have been revised for early diagnosis and risk stratification of patients with PH.
Using the 2015 definitions, the development of a precapillary component of PH in …
| | | |
Angiotensin Receptor Neprilysin Inhibition and Cardiovascular Outcomes Across the Kidney Function Spectrum: The PARAGON-HF Trial
FR Mc Causland, M Vaduganathan, B Claggett, M Gori… - JACC: Heart Failure, 2024
Background Lower estimated glomerular filtration rate (eGFR) may be one of the
major reasons for hesitation or failure to initiate potentially beneficial therapies in
patients with heart failure (HF). Objectives This study sought to assess if the effects of …
major reasons for hesitation or failure to initiate potentially beneficial therapies in
patients with heart failure (HF). Objectives This study sought to assess if the effects of …
| | | |
Okechukwu Ogah
Nov 24, 2024, 11:52:53 AM11/24/24
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CY Chang, CC Chen, ML Tsai, MJ Hsieh, TH Chen… - JACC: Asia, 2024
Background Few studies have incorporated echocardiography and laboratory data to
predict clinical outcomes in heart failure with preserved ejection fraction (HFpEF).
Objectives This study aimed to use machine learning to find predictors of heart failure …
predict clinical outcomes in heart failure with preserved ejection fraction (HFpEF).
Objectives This study aimed to use machine learning to find predictors of heart failure …
| | | |
[PDF] Efficacy of sacubitril/valsartan combined with dapagliflozin in treating patients with heart failure and diabetes after an acute myocardial infarction
L Zhang, X Tang, R Li, J Niu, J Gong - Pakistan Journal of Medical Sciences, 2024
Objective: To investigate the efficacy of sacubitril/valsartan combined with
dapagliflozin in diabetic patients suffering from heart failure following an acute
myocardial infarction. Methods: This retrospective study included 80 diabetic patients …
dapagliflozin in diabetic patients suffering from heart failure following an acute
myocardial infarction. Methods: This retrospective study included 80 diabetic patients …
| | | |
Impact of SGLT2 Inhibitors on Cardiovascular Outcomes Following Acute Myocardial Infarction with Heart Failure with Preserved Ejection Fraction: A Propensity …
T Calcagno, R Issa, G MAHALWAR, R Issa, A Brateanu… - Circulation, 2024
Background: Sodium-glucose co-transporter-2 (SGLT2) inhibitors have effectively
reduced cardiovascular mortality and hospitalizations in heart failure with preserved
ejection fraction (HFpEF). This study investigates their effects on patients with HFpEF …
reduced cardiovascular mortality and hospitalizations in heart failure with preserved
ejection fraction (HFpEF). This study investigates their effects on patients with HFpEF …
| | | |
Effect of eplerenone in acute heart failure using a win ratio approach
M Kobayashi, A Yamashina, K Satomi, A Tezuka… - Clinical Research in …, 2024
Mineralocorticoid receptor antagonists (MRA) are recommended for use in heart
failure (HF) and a reduced ejection fraction (HFrEF), evidencing by reduction of
mortality and morbidity in patients with chronic HFrEF and those with left ventricular …
failure (HF) and a reduced ejection fraction (HFrEF), evidencing by reduction of
mortality and morbidity in patients with chronic HFrEF and those with left ventricular …
| | | |
Effects of sacubitril/valsartan according to background beta-blocker therapy in patients with heart failure and reduced ejection fraction: Insights from PARADIGM-HF
SD Gupta, JH Butt, EGM McMurray, A Talebi… - European journal of heart failure
Aims Beta-blockers may inhibit neprilysin activity and conversely, neprilysin
inhibition may have a sympatho-inhibitory action. Consequently, sacubitril/valsartan
may have a greater effect in patients not receiving a beta-blocker compared to those …
inhibition may have a sympatho-inhibitory action. Consequently, sacubitril/valsartan
may have a greater effect in patients not receiving a beta-blocker compared to those …
Okechukwu Ogah
Nov 26, 2024, 4:03:03 PM11/26/24
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[PDF] Machine learning for stroke in heart failure with reduced ejection fraction but without atrial fibrillation: A post‐hoc analysis of the WARCEF trial
H Ishiguchi, Y Chen, B Huang, Y Gue, E Correa… - European Journal of Clinical …, 2024
Background The prediction of ischaemic stroke in patients with heart failure with
reduced ejection fraction (HFrEF) but without atrial fibrillation (AF) remains
challenging. Our aim was to evaluate the performance of machine learning (ML) in …
reduced ejection fraction (HFrEF) but without atrial fibrillation (AF) remains
challenging. Our aim was to evaluate the performance of machine learning (ML) in …
| | | |
[HTML] Addition of Sacubitril/Valsartan to Mineralocorticoid Receptor Antagonist Therapy in Primary Aldosteronism: Effects on Plasma Aldosterone Concentration and Plasma …
K Okamura, M Matsushima, Y Takamiya, T Okuda… - Journal of Clinical Medicine …, 2024
In the pharmacologic treatment of primary aldosteronism (PA), titration of
mineralocorticoid receptor antagonist (MRA) dosing is necessary to reverse the renin
suppression caused by high aldosterone levels. However, we often encounter cases …
mineralocorticoid receptor antagonist (MRA) dosing is necessary to reverse the renin
suppression caused by high aldosterone levels. However, we often encounter cases …
Okechukwu Ogah
Nov 28, 2024, 1:03:30 PM11/28/24
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[PDF] Right ventricular function and anemia in heart failure with preserved ejection fraction
J Wang, J Jiang, X Li, X Tan, Y Zhou, Z Luo, X Wang… - Frontiers in Cardiovascular …, 2024
Background Anemia is a common complication in patients with heart failure and is
associated with left ventricular systolic dysfunction. However, its role in right
ventricular (RV) function has not been evaluated. Methods We retrospectively …
associated with left ventricular systolic dysfunction. However, its role in right
ventricular (RV) function has not been evaluated. Methods We retrospectively …
| | | |
[PDF] Efficacy and safety of sacubitril/valsartan on postoperative atrial fibrillation in adult patients undergoing cardiac surgery: a real-world observational study
X Chen, P Liu, F Zhu, D Wang, S Yang, W Yan - Frontiers in Cardiovascular Medicine, 2024
Background The mechanism underlying new-onset postoperative atrial fibrillation
(POAF) in adult cardiac surgery is not well understood. However, efficient
pharmacological methods to prevent and treat arrhythmic complications are still …
(POAF) in adult cardiac surgery is not well understood. However, efficient
pharmacological methods to prevent and treat arrhythmic complications are still …
| | | |
[PDF] Prevalence of white matter lesions in rheumatic heart disease patients with mitral valve disease
V Singh, L Chaudhari, SJ Chiramel, D Krishnappa…
Background: Rheumatic heart disease (RHD) patients are at high risk of neurological
insults even in absence of atrial fibrillation and traditional risk factors for stroke. White
matter lesions (WML) on MRI are surrogates for the same. Methods: We conducted a …
insults even in absence of atrial fibrillation and traditional risk factors for stroke. White
matter lesions (WML) on MRI are surrogates for the same. Methods: We conducted a …
Okechukwu Ogah
Nov 29, 2024, 6:32:12 AM11/29/24
to nigerian-car...@googlegroups.com
[PDF] Impact of Sacubitril/Valsartan in Improving Home Time for Patients With Heart Failure
J Hiremath, SN Routray, P Hazra, D Gandotra… - Cureus, 2024
Home time, defined as time spent by the patient alive and out of any healthcare
institution, is an important patient-centric outcome for patients with cardiovascular
disease. Home time is recognized as a crucial measure of recovery post …
institution, is an important patient-centric outcome for patients with cardiovascular
disease. Home time is recognized as a crucial measure of recovery post …
| | | |
[HTML] Systemic Embolism and Clinically Significant Bleeding Events in Older Adults with Nonvalvular Atrial Fibrillation After Treatment with Direct Oral Anticoagulants and …
D Yaguchi, S Sera, A Okada, Y Nishimura, S Tamaru… - Pharmaceutics, 2024
Background/Objectives: Anticoagulant therapy, particularly the use of direct oral
anticoagulant agents (DOACs), is recommended for patients with nonvalvular atrial
fibrillation (NVAF). This multicenter observational retrospective cohort study aimed to …
anticoagulant agents (DOACs), is recommended for patients with nonvalvular atrial
fibrillation (NVAF). This multicenter observational retrospective cohort study aimed to …
| | | |
[HTML] Individualised prediction of major bleeding in patients with atrial fibrillation treated with anticoagulation
AP Toft-Petersen, C J.-Y. Lee, M Phelps, B Ozenne… - PloS one, 2024
Background Anticoagulation in atrial fibrillation (AF) increases the risk of major
bleeding. No predictive model has hitherto provided estimates of the absolute risk for
individual patients. Aim To predict the individual 1-year risk of major bleeding in …
bleeding. No predictive model has hitherto provided estimates of the absolute risk for
individual patients. Aim To predict the individual 1-year risk of major bleeding in …
| | | |
Association Between Right Ventricular-Pulmonary Arterial Coupling and Outcomes in Patients with Heart Failure with Preserved Ejection Fraction
A Sherafati, A Kloster, S Manandhar, A Fares… - Circulation, 2024
Introduction: Right ventricle (RV)-pulmonary artery (PA) coupling reflects functional
adaptation of RV to afterload. Impaired RV-PA coupling is associated with worse
outcomes in patients with pulmonary hypertension. However, the association …
adaptation of RV to afterload. Impaired RV-PA coupling is associated with worse
outcomes in patients with pulmonary hypertension. However, the association …
| | | |
[HTML] Predictive modeling of preoperative acute heart failure in older adults with hypertension: a dual perspective of SHAP values and interaction analysis
Q Yu, Z Hou, Z Wang - BMC Medical Informatics and Decision Making, 2024
Background In older adults with hypertension, hip fractures accompanied by
preoperative acute heart failure significantly elevate surgical risks and adverse
outcomes, necessitating timely identification and management to improve patient …
preoperative acute heart failure significantly elevate surgical risks and adverse
outcomes, necessitating timely identification and management to improve patient …
| | | |
[PDF] Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy
J Borger, E Zweck, C Moos, P Horn, F Voß… - ESC Heart Failure, 2024
Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are
hallmarks of heart failure (HF) pathophysiology. The extent of myocardial
inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated …
hallmarks of heart failure (HF) pathophysiology. The extent of myocardial
inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated …
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[HTML] Population-based approaches to increase hypertension control: an urgent need
C Richardson, SJ Battle, DJ DiPette - Hypertension Research, 2024
Recent data from the World Health Organization (WHO) demonstrates that between
the years 2000–2021, the number one cause of non-communicable disease mortality
was ischemic heart disease [1]. In 2024 the Centers for Disease Control (CDC) in the …
the years 2000–2021, the number one cause of non-communicable disease mortality
was ischemic heart disease [1]. In 2024 the Centers for Disease Control (CDC) in the …
Okechukwu Ogah
Nov 30, 2024, 7:16:05 AM11/30/24
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Inhibition of miR-92a normalizes vascular gene expression and prevents diastolic dysfunction in heart failure with preserved ejection fraction
B Kattih, A Fischer, M Muhly-Reinholz, L Tombor… - Journal of Molecular and …, 2024
Heart failure with preserved ejection fraction (HFpEF) remains a major public health
burden with increasing prevalence but only few effective therapies. Endothelial
dysfunction and inflammation are identified as pathophysiological drivers of HFpEF …
burden with increasing prevalence but only few effective therapies. Endothelial
dysfunction and inflammation are identified as pathophysiological drivers of HFpEF …
| | | |
[PDF] Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial
N Aiad, J du Fay de Lavallaz, MJ Zhang, T Chaikijurajai… - ESC Heart Failure, 2024
Abstract Background and Aims Patients with heart failure with preserved ejection
fraction (HFpEF) tend to have low resting and exercise heart rates.
Phosphodiesterase‐3 (PDE‐3) inhibitors improve heart rates, haemodynamics and …
fraction (HFpEF) tend to have low resting and exercise heart rates.
Phosphodiesterase‐3 (PDE‐3) inhibitors improve heart rates, haemodynamics and …
| | | |
[PDF] Association Between Direct Oral Anticoagulant Score and Bleeding Events in Patients With Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: A …
Y Harano, M Yamamoto, T Shimura, M Okubo… - Journal of the American …, 2024
Background The Direct Oral Anticoagulant (DOAC) Score can predict bleeding risk in
patients with atrial fibrillation taking DOACs; however, it lacks external validation.
Therefore, this study aimed to assess the association between the DOAC Score and …
patients with atrial fibrillation taking DOACs; however, it lacks external validation.
Therefore, this study aimed to assess the association between the DOAC Score and …
| | | |
Effect of Sacubitril/Valsartan in Patients with Concomitant Heart Failure with Reduced Ejection Fraction and End-Stage Renal Disease on Hemodialysis
Y Ahn, MH Jung, JC Youn, DH Cho, J Choi, BS Yoo - Circulation, 2024
Aims: This study aimed to explore the comparative effectiveness of
sacubitril/valsartan (SV) to renin-angiotensin system (RAS) blockade in patients with
concomitant heart failure with reduced ejection fraction (HFrEF) and end-stage renal …
sacubitril/valsartan (SV) to renin-angiotensin system (RAS) blockade in patients with
concomitant heart failure with reduced ejection fraction (HFrEF) and end-stage renal …
| | | |
[PDF] Industry marketing payments to physicians and prescription patterns for sacubitril/valsartan in the USA
A Murayama - Heart, 2024
Objectives Although financial interactions between physicians and pharmaceutical
and medical device companies could be potential conflicts of interest, in certain
instances, industry promotion targeted at physicians may facilitate the early adoption …
and medical device companies could be potential conflicts of interest, in certain
instances, industry promotion targeted at physicians may facilitate the early adoption …
| | | |
[HTML] Subtle signs of atrial cardiomyopathy and left ventricular diastolic dysfunction are associated with reduced cognitive function: results from the Hamburg City Health …
AH Ohlrogge, S Camen, L Nagel, J Brederecke… - Clinical Research in …, 2024
Background Atrial fibrillation is associated with cognitive dysfunction. Atrial
cardiomyopathy has been correlated with both entities. We aimed to characterize the
association of echocardiographic parameters of atrial cardiomyopathy with cognitive …
cardiomyopathy has been correlated with both entities. We aimed to characterize the
association of echocardiographic parameters of atrial cardiomyopathy with cognitive …
| | | |
[PDF] Discontinuation and reinitiation of mineralocorticoid receptor antagonists in patients with heart failure and reduced ejection fraction
L Landucci, UL Faxén, L Benson, U Dahlström… - European Journal of Heart …, 2024
Aims Mineralocorticoid receptor antagonists (MRA) improve outcomes in heart failure
with reduced ejection fraction (HFrEF) but are underused. Point prevalent use has
been described, but the kinetics of discontinuation and the extent of reinitiation have …
with reduced ejection fraction (HFrEF) but are underused. Point prevalent use has
been described, but the kinetics of discontinuation and the extent of reinitiation have …
Okechukwu Ogah
Dec 1, 2024, 8:30:01 AM12/1/24
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[PDF] Right ventricular function and anemia in heart failure with preserved ejection fraction
J Wang, J Jiang, X Li, X Tan, Y Zhou, Z Luo, X Wang… - Frontiers in Cardiovascular …, 2024
Background Anemia is a common complication in patients with heart failure and is
associated with left ventricular systolic dysfunction. However, its role in right
ventricular (RV) function has not been evaluated. Methods We retrospectively …
associated with left ventricular systolic dysfunction. However, its role in right
ventricular (RV) function has not been evaluated. Methods We retrospectively …
| | | |
The effect of sacubitril/valsartan on epicardial adipose tissue in patients with chronic heart failure and reduced left ventricular ejection fraction
H Mori, S Nakamori, N Fujimoto, H Mizutani, T Kokawa… - Circulation, 2024
Background: Natriuretic peptides (NPs) have been reported to have beneficial effects
on adipose tissue, as well as the cardiovascular system and kidneys. Epicardial
adipose tissue (EAT) has been recognized as an important target for the treatment of …
on adipose tissue, as well as the cardiovascular system and kidneys. Epicardial
adipose tissue (EAT) has been recognized as an important target for the treatment of …
| | | |
[PDF] Short-Term Echocardiographic Evaluation by Global Longitudinal Strain in Patients with Heart Failure Treated with Sacubitril/Valsartan
EA Eldaraky, MA Tabl, LA Khedr, MM Ibrahim… - Benha Medical Journal, 2024
Background: Heart failure (HF) is a clinical syndrome characterized by dyspnea,
easy fatigability, and fluid retention. This study aimed to assess the effects of ARNI on
GLS and myocardial mechanics in patients with HFrEF. Methods: This prospective …
easy fatigability, and fluid retention. This study aimed to assess the effects of ARNI on
GLS and myocardial mechanics in patients with HFrEF. Methods: This prospective …
| | | |
Diabetic Cardiomyopathy
M Nandave - Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors in …, 2024
Diabetes cardiomyopathy (DCM) is a heart condition that leads to heart failure and is
associated with increased mortality in diabetic individuals. It is distinguished by
systolic and diastolic dysfunction, occurring independently of hypertension or …
associated with increased mortality in diabetic individuals. It is distinguished by
systolic and diastolic dysfunction, occurring independently of hypertension or …
Okechukwu Ogah
Dec 9, 2024, 12:03:15 AM12/9/24
to nigerian-car...@googlegroups.com
[HTML] Smartphone App for Improving Self-Awareness of Adherence to Edoxaban Treatment in Patients With Atrial Fibrillation (ADHERE-App Trial): Randomized Controlled …
M Yoon, JH Lee, IC Kim, JH Lee, MN Kim, HL Kim… - Journal of Medical Internet …, 2024
Background Adherence to oral anticoagulant therapy is essential to prevent ischemic
stroke in patients with atrial fibrillation (AF). Objective This study aimed to evaluate
whether smartphone app–based interventions improve medication adherence in …
stroke in patients with atrial fibrillation (AF). Objective This study aimed to evaluate
whether smartphone app–based interventions improve medication adherence in …
| | | |
[HTML] Home blood pressure and hypertension control
M Siddiqui, JB Byrd - Hypertension Research, 2024
A majority of contemporary hypertension guidelines recommend out-of-office blood
pressure (BP) monitoring to confirm the presence or absence of high office BP [1, 2,
3, 4]. There are two approaches for out-of-office BP monitoring: ambulatory BP …
pressure (BP) monitoring to confirm the presence or absence of high office BP [1, 2,
3, 4]. There are two approaches for out-of-office BP monitoring: ambulatory BP …
Okechukwu Ogah
Dec 9, 2024, 12:39:44 PM12/9/24
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Sex Differences and Clinical Outcomes, Including Ventricular Tachyarrhythmias, of Patients with Heart Failure with Reduced Ejection Fraction Treated with Sacubitril …
M Abumayyaleh, C Krack, J Demmer, C Pilsinger… - Frontiers in Cardiovascular …
Women with heart failure with reduced ejection fraction (HFrEF) often experience
worse clinical outcomes compared to men, including higher rates of mortality,
hospitalization, and congestion. However, the effects of sacubitril/valsartan on these …
worse clinical outcomes compared to men, including higher rates of mortality,
hospitalization, and congestion. However, the effects of sacubitril/valsartan on these …
| | | |
Diabetic Cardiomyopathy
M Nandave - Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors in …, 2024
Diabetes cardiomyopathy (DCM) is a heart condition that leads to heart failure and is
associated with increased mortality in diabetic individuals. It is distinguished by
systolic and diastolic dysfunction, occurring independently of hypertension or …
associated with increased mortality in diabetic individuals. It is distinguished by
systolic and diastolic dysfunction, occurring independently of hypertension or …
Okechukwu Ogah
Dec 15, 2024, 3:45:54 PM12/15/24
to nigerian-car...@googlegroups.com
Discharge Medication After Natriuresis-Guided Dosing of Diuretic Therapy in Patients Hospitalized for Acute Heart Failure: A PUSH-AHF Substudy
AA Voors, K Damman, IE Beldhuis, P van der Meer… - Heart Failure, 2024
A natriuretic-guided approach, where only those with an insufficient natriuretic
response received a higher dose of loop diuretic agents or addition of other diuretic
drugs, resulted in better diuresis and natriuresis with an overall higher dose of total …
response received a higher dose of loop diuretic agents or addition of other diuretic
drugs, resulted in better diuresis and natriuresis with an overall higher dose of total …
| | | |
[PDF] Machine learning for stroke in heart failure with reduced ejection fraction but without atrial fibrillation: A post‐hoc analysis of the WARCEF trial
H Ishiguchi, Y Chen, B Huang, Y Gue, E Correa… - European Journal of Clinical …, 2024
Background The prediction of ischaemic stroke in patients with heart failure with
reduced ejection fraction (HFrEF) but without atrial fibrillation (AF) remains
challenging. Our aim was to evaluate the performance of machine learning (ML) in …
reduced ejection fraction (HFrEF) but without atrial fibrillation (AF) remains
challenging. Our aim was to evaluate the performance of machine learning (ML) in …
| | | |
Comparative Analysis of Mineralocorticoid Receptor Antagonists and Renin-Angiotensin System Inhibitors/Angiotensin Receptor Neprilysin Inhibitor in Heart Failure …
CC Lee, TW David, KC Chang, TT Lin, CK Wu, LY Lin - Frontiers in Pharmacology
Figure: 3 0.78-1.02) or HHF (hazard ratio= 1.01, 95% CI: 0.94-1.09). Conversely,
RASI//ARNI use was linked to a lower risk of cardiovascular death (hazard ratio=
0.82, 95% CI: 0.71-0.94) but not HHF (hazard ratio= 0.995, 95% CI: 0.924-1.07) …
RASI//ARNI use was linked to a lower risk of cardiovascular death (hazard ratio=
0.82, 95% CI: 0.71-0.94) but not HHF (hazard ratio= 0.995, 95% CI: 0.924-1.07) …
| | | |
[HTML] Prospective registry of heart failure with preserved ejection fraction in México: EDIFICE-Mx
D Araiza-Garaygordobil, OU Preciado-Gutierrez… - American Heart Journal …, 2024
Background and aims Heart failure with preserved ejection fraction (HFpEF) is an
increasingly common clinical syndrome, estimated to constitute approximately 50%
of all heart failure (HF) cases. Nonetheless, registries from specific geographic areas …
increasingly common clinical syndrome, estimated to constitute approximately 50%
of all heart failure (HF) cases. Nonetheless, registries from specific geographic areas …
| | | |
Fetuin-A as a plausible biomarker for cardiac valve calcification in rheumatic heart disease patients from North India
A Rani, L Singh, A Chakraborti, S Gupta, H Singh… - Asian Cardiovascular and …, 2024
Background Rheumatic heart disease (RHD) remains a persistent public health
challenge, particularly prevalent in developing and underdeveloped regions despite
concerted global eradication efforts. The progressive stage of RHD, marked by …
challenge, particularly prevalent in developing and underdeveloped regions despite
concerted global eradication efforts. The progressive stage of RHD, marked by …
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