Thanks David, indeed you are absolutely right. The power supply with LT1308B is very reliable and not as sensitive to layout design as other ones that I have tried.
LT1308B has in Iq of 0.01uA in stand-by, as you say. I've built your nixie watch (picture attached) and in my design it seems to use 2.3uA. If I build the HVPS on a breadboard, I can measure 0.1uA or less, which is great (I guess the resolution of my multimeter Keysight U1241B cannot measure less than 0.1uA accurately but that's great at 0.1uA or less). Of course I have tried to troubleshoot my LT1308B HVPS with no success. In my quest for a more efficient HVPS, I have designed a power supply using the MAX668 chip (as per datasheet and similar to many commercial HVPS), this was tricky to design with no noise, it works well now (after 6 different designs) however the stand-by power is 2.4uA, as per datasheet. So I can have higher efficiency than with LT1308B but also higher stand-by current (I believe because MAX668 has an internal LDO).
Which is why I was thinking whether I can use a high load switch to truly bring shutdown current to zero using a power supply built around MAX668. Of course, this is a bit of a (pointless) extreme challenge to reduce stand-by current as much as possible to break even with solar panels, but that's where the fun is for me. And of course I could keep on troubleshooting the LT1308B design, it actually works perfectly other than it gives me higher stand-by current than on the datasheet, not sure if that depends on the design layout. But then again, I'm only a hobbyist and not an engineer, so I may be missing something.
So any suggestions on why my LT1308B draws more than 1uA with SHTN=0V welcome (I have tried 4 different chips, same thing on the PCB, fine on the breadboard). Or any other suggestions to use any other power supply with perhaps a high load switch to bring standby current to less than 1uA, which I worry is unnecessary additional components and introduces a potential start-up delay.