From what I've read, the peak current is what leads to tube wearout, and the effect is exponential: double the current, and the lifetime will be less than half the normal expectancy. So when a tube is pulsed, such as with multiplexing, the perceived brightness will always be lower compared to static operation and the only way to compensate for that is higher current. If you have a single tube you can control with a microcontroller, you can easily emulate how it will appear when multiplexed.
I have limited data on perceived brightness vs current. When I was taking extensive data on my b7971 and RZ568m tubes, I found that once you get to about 75% of normal operating current, further increases in current dont give as noticeable increase in brightness. Of course, this is subjective because I didn't use a photometer to measure the optical output. I never attempted to get PWM data, because I only use direct-drive in my designs.
Multiplexing is tricky because you have to tradeoff between peak current, duty-cycle, frequency, dead-time (to minimize ghosting), ambient lighting. Ultimately, it amounts to a tradeoff between brightness and tube life. Some folks have said you can actually hear tubes making noise when multiplexed or PWM-dimmed, and I've often wondered if the mechanical stresses involved in producing the noise affect the tube's life.
The best way to prolong tube life is to make sure you never exceed the maximum current rating in the datasheet. Better manufacturers will provide both min and max values, and if they dont provide a typical value, then use the average of min & max to select the operating current.
Next, use a cheap passive- infrared motion sensor (PIR) to shut off the display when nobody is around, or when you are asleep. This will greatly extend the life of your tubes.
Unless the tube is specifically designed for multiplexed operation, such as multi-digit displays that have shared cathodes, your best option is to use direct-drive to maximize lifetime. Electronic parts are inexpensive and readily available; nixie tubes are expensive and the finite supply is rapidly shrinking.