I would recommend looking at LT3750 l LT3751. They have a refernce design for a 300V 6A capacitor charger (can be modified to nixie supply) and also there is a 500V, 150mA flyback design, which could be modified.I think going flyback is the best version. Of course one also could build an isolated mains supply.

I did a short test with the components shared in “yet another nixie power supply”, just changed the output caps (450V) and the voltage divider.
It worked ok with 300V/40mA, the efficiency is not great but ok, 87.8% with 12V input voltage, the transformer temperature stabilized around 42 ° C.
Unfortunately the LT3757 is difficult to solder, I always need a lamp with a magnifying glass. I think there is no trough-hole version.
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