@Richard
I am running Windows 10 and my screen is set to custom 130% scaling on the 15.6" 1920x1080 screen since the default 125% is a bit too small for my eyes.
MLO is not DPI aware. That means that Windows will scale the application up. This means that it takes the "image" of the screen and enlarges it (by 1.3x in my case). When you enlarge bitmaps they get more fuzzy. A 1.25x is a bit better than 1.3x, but it still will be a bit fuzzy.
If an application is programmed DPI aware then it knows when it should draw at higher resolution and will make the UI for the higher resolution with more pixels which will result in crisp text and lines ... icons depend on the embedded image quality.
A work-around right now is to tell Windows to not scale the application. Then it will draw at its original pixels and be crisp, but be, in my case, 23% smaller than it should be. This results in a hard to read UI. A lot of items do work and I tell MLO to use bigger fonts which works for most of the UI, but the settings screen for example are still small.
In regular use that's OK - except for the "Filter" and "Properties" section on the left and right bottom which don't scale up (completely).
It's not great, but it may be somewhat workable (for me) after all.
Don't try to run it on a 4K screen in that mode though. I am pretty sure it'll be unrecognizable without using the magnifier.