Almost impossible to answer in such generality.
First you can write the same model in Fusion in much more or much less efficient ways.
Second, whether it is worthwhile depends on what time it takes to model the problem compared to solving it.
Fusion has to do some processing, so there is real work it performs. The passage from Python Optimizer API to C Optimizer API is much thinner, this layer just passes data backend forth.
Whichever one you use the time to set up the problem should be a small fraction of the time it takes to solve it. If that is not the case then something is out of proportion.
Michal