

just for the purpose of storing the fluence output, mcx needs to allocates 8-byte per voxel per time gate. based on your domain size, you will need at least 54GB of memory for storing fluence alone, not mention other buffers needed for the simulation.
the question is - does your GPU have 54GB of graphics memory? similarly, what is the size of your host/CPU memory?
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sorry, I miscalculated - you will need 216 GB GPU memory = 3000^3*8 bytes, which is not physically possible.