Seth- It's very common that people run multiple application servers off a single database on the back end, it allows for scaling / load-balancing for one.
I'm not sure what Mark is referring to specifically regarding updates, I think his concern here could be with the ORM actually altering the schema.
There shouldn't be a problem with updating the database from multiple application servers, you get into complexity with that where you have multiple database servers you want to keep in sync, in that scenario having one write master and multiple read-only slaves can make sense but multiple app servers should all be able to update the same back end database safely.