Nick, Just adding to Jonathan's comments I would also suggest talking to your plumber about the 2 port valves and using the end switch to control the pump, in my experience most heating engineers don't like omitting the end switches as if the valve fails to open for some reason you will be pumping against a closed valve and likely to damage pumps and or boiler if it doesn't get proper flow once fired.
I had a lot of trouble initially getting plumbers to understand Loxone in terms of heating - the easiest way i found to explain it was telling them that Loxone was essentially a fancy room stat that called for heat from a Relay channel just like any other heating controller would.
For our newbuild I have run the following to each of our 4 Manifolds, a 5core cable per 4 manifold actuators (common neutral), a Tree Cable, 2 Core T&E for the pump, a 5 Core for a future blending valve and a Cat 5 for the 1 Wire sensors installed in the manifolds.
I have yet to decide on whether to use Tree actuators or standard Mains ones hence the addition of the 5cores for actuators
A further 2x5 core will run from the heating wiring center to the Call for heat relays (Miniserver) to open the 5 2-port valves (4 heating plus DHW) - the 2nd 5 core also takes the perm live power back to the relays from the wiring centre to make sure that isolating the power to the heating wiring centre isolates everything rather than have the potential for call for heat to come live whilst someone is working on it.
Adding SFCU's local to the pumps to allow for proper safe maintenance of the pumps is also essential