Hi Nick,
The Tree cable which is sold by Loxone now is somewhat different to the old Tree cable, which was essentially a green sleeved Cat7, and is what was mentioned above by DanF.
The newer Tree cable has the two thin pairs, Green/White (Tree) and Orange/White (24V DC), as well as the thicker 1.5mm2 orange/white (24V DC) cores (only used by the Loxone light fittings or if you want to power something 3rd party) - remember to connect those larger cores every time using Wagos behind switches or at connection points to give you flexibility later on
With the new generation Lxone Tree Cable there are no spare cores so there is no scope for things like door/windows contacts, the outdoor PIR etc without using Cat6 et al entirely separately - so there is no benefit to running the Tree cable back to a central point from each room and at about 300 odd quid for a box of 200M spend some time thinking through the most sensible and economical route around the house before you start.
If running parallel to mains cabling over any kind of distance try to keep about 18inches seperation between the two
I typically do one Tree per floor plus another for external - so for a 2 storey house ground floor would be on the miniserver, 1st floor would be Tree Extension Left, External Tree Extension Right.
Everything per floor is daisy chained and follows a consistent pattern within each room - I normally start with a light switch as pretty much every room has one - not everywhere has presence sensors or Loxone light fittings etc in the ceiling
Heating valve actuators are on the respective floors Tree branch if using Loxone actuators.
For my own house I am using third party actuators via a relay channel with point to point mains wiring as it is a fraction of the cost - I plan on using Modbus Relays rather than Loxone ones initially to see how well they last - I will however make sure the Tree cable reaches the 4 manifold locations just in case I decide I want to use them later.
I have yet to hit 50 device limit per floor but I don't do mansions!
If you have any external Tree devices (in waterproof boxes or outbuldings etc) have them on a seperate Tree branch - no matter how hard you try water finds its way into external boxes so having a tree failure on the outside only branch doesn't mean darkness in the house!!
Worst Case, most things in the Loxone universe are available in the Air wireless version so don't get too caught up on adding loops of cable here and there "just in case" - there is also an Air transmitter that is small enough to put in a back box behind a switch to provide covrage rather than using the Air extension mounted in the panel.
I don't bother tring to "hybrid" the wiring for a future change of solution, if someone takes Loxone out and wants something else, then its a rewire and they have to live with that - sounds harsh but for me there is no value in installing a solution with half an eye on how to take it back out again in future
Paul