There can only be one outstanding read or write at a given time on a given stream, but reads and writes can happen in parallel. So you're guaranteed that no more than one thread will be in OnReadDone() at once, and no more than one thread will be in OnWriteDone() at once, but you could have one thread in OnReadDone() while another thread is in OnWriteDone().
OnDone() will not be invoked until after all of the other reaction methods are complete.