I read the Nature method paper today. Giggle seems to be a very powerful and efficient search engine against the huge annotation database.
As a biological researcher not familiar with Linux and coding environment, I wonder whether giggle has a website-based interface where people can upload CHIP-seq bed file and choose which annotation dataset they want to compare to.
I think it would be much more helpful to the community where many scientist generate sequencing data but lack bioinformatics skills.