Reference for ROI-Constrained Correlational Tractography in DSI Studio
taravat rasooli
Dear Dr. Yeh,
I am writing to ask for your guidance regarding the appropriate reference for ROI-constrained correlational tractography in DSI Studio.
In our study, we performed correlational tractography restricted to predefined white matter bundles using ROI constraints in the group connectometry analysis. Following your previous suggestion, we first performed whole-brain correlational tractography and confirmed that the bundles identified in the ROI-based analyses were also present in the whole-brain results.
We also evaluated the stability of the ROI-based findings using 3,000 to 8,000 randomized permutations. We did not observe any meaningful differences in the identified significant bundles or the overall findings across these permutation counts.
We could not identify a methodological or validation paper specifically describing ROI-constrained correlational tractography within DSI Studio.
Could you please advise whether there is a peer-reviewed reference that specifically supports this ROI-based correlational tractography approach?
Thank you very much for your time and guidance.
Best regards,
Taravat Rasooli
Frank Yeh
Dear Taravat,
There is no separate peer-reviewed paper specifically for ROI-constrained correlational tractography in DSI Studio. The ROI-constrained analysis is not a different statistical method from correlational tractography/connectometry; it is a restricted search space or an ROI-guided analysis using the same framework.
I would suggest citing the original correlational tractography/connectometry and DSI Studio method papers, and then describe clearly in your Methods that the analysis was restricted to predefined white matter bundles using ROI constraints. It is also good that you confirmed the findings in the whole-brain analysis, because this helps show that the ROI results are not only produced by the restricted search space.
For the manuscript, I would avoid presenting ROI-constrained correlational tractography as a separately validated method. Instead, describe it as a hypothesis-driven ROI-restricted implementation of correlational tractography, with whole-brain confirmation and permutation testing for stability.
Best regards,
Frank
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