OK, I got it.
As it turns out, GDAL has everything you need, including the SQLite database. There is only one important fact, you have to load the DLL prior Django loads his SQLite. Because Django loads the one from Python it self. Therefore i did put the necessary code into the settings.py. Because Django has first to load the settings, before it can load the correct database middleware (SQLite, PostgreSQL, MariaDB,...). The code is in the Picture below.
mpoly = models.MultiPolygonField(null=True)
Should I open a ticket for this, or is this mailing list enough?