mariadb/mysql database (2006, 'MySQL server has gone away')

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I think I'm experiencing an issue related to:

https://github.com/django/channels/issues/1234

where I get (2006, 'MySQL server has gone away') after trying to establish a new channels connection with calls using database_sync_to_async(). I have set my Django DB CONN_MAX_AGE to 300 (5 minutes) and my MariaDB wait_timeout to 28800 (was 600 originally). All this did was extend the time before I saw the issue.

Why would Django not be clearing out old connections, and why doesn't it just open a new one?

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I'm still having this issue, and it definitely seems Channels related. When the issue occurs, I can logout/login and do other things on the Django only portion of the site. As soon as I try to make DB requests from within a Channels consumer, the error pops up. Restarting the Daphne server resolves the issue.