Ok, thanks guys. I'll answer myself.
At the moment I am more focused on the problem. I think it's an off-topic here. In short, the problem should be solved at the client side, not on the server side. Node.js can handle this with node-serialport and Garrows has a development one step further:
https://github.com/garrows/browser-serialport, "... works in Chrome App Packaged as this is the only way to get access to the serial ports API in the browser ".
A Few years ago, Nicholas Zambetti developed seriallity as a browser-plugin,
http://www.zambetti.com/projects/seriality/So I will learn a little more, try and maybe I will move the question to another forum more involved.
Many thanks to everyone, once more.