Spider Beer Overview: Making Yeast Produce Black Widow Silk

[Cabalen sciences]

https://www.youtube.com/watch?v=Fx8TcGrCOSI

The Thought Emporium just made a video on how to make silk from Yeast. 

[Daniel C.]

I'd heard there was a mechanical component for getting spider silk to form correctly, so just having the proteins in solution wasn't enough.  Is that wrong?

-Dan

On Thu, Oct 11, 2018 at 7:32 PM Cabalen sciences <ryangav...@gmail.com> wrote:

https://www.youtube.com/watch?v=Fx8TcGrCOSI

The Thought Emporium just made a video on how to make silk from Yeast. 

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[Nathan McCorkle]

On Fri, Oct 12, 2018, 7:05 AM Daniel C. <dcroo...@gmail.com> wrote:

I'd heard there was a mechanical component for getting spider silk to form correctly, so just having the proteins in solution wasn't enough.  Is that wrong?

-Dan

Yeah, you need a spinner, and I think the supply to the spinner requires different properties than simple cell lysate/exudate (I'm guessing that has to do with purity and concentration).

[Daniel C.]

On Fri, Oct 12, 2018 at 12:49 PM Nathan McCorkle <nmz...@gmail.com> wrote:

Yeah, you need a spinner, and I think the supply to the spinner requires different properties than simple cell lysate/exudate (I'm guessing that has to do with purity and concentration).

So is this guy on a fool's errand?  Even if he can make yeast that makes the protein, he won't have actual strands of silk?  Or is there a way to extrude it without growing a full spider?

-Dan 

[Cathal Garvey]

Per the success of the "spider-goat" project, you can extrude spider silk from concentrated solution. IIRC, the quality of the resulting silk is far lower than that produced by spinnerets. Last time I looked the best and most practical route was engineered silkworms.

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[djwr...@gmail.com]

https://boltthreads.com/technology/microsilk/

Not a fool’s errand at all

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[Daniel C.]

On Sat, Oct 13, 2018 at 7:41 AM <djwr...@gmail.com> wrote:

https://boltthreads.com/technology/microsilk/

Not a fool’s errand at all

That's pretty cool!  It looks like they're still in development though, since they don't offer any actual products for sale.  Hopefully we won't have to wait too long.

-Dan