Re: notahelix.net

[Nathan McCorkle]

There are definitely people at Universities teaching that DNA isn't
always in a canonical form. Here are some recent studies that are
getting close and closer to looking at things in their natural state,
we're on our way to approach Heisenberg's uncertainty principle. There
are plenty of people who want to know what is really going on.

How I searched:
(used the terms 'cryo em DNA nucleus in-vivo tomography' and then
chose since 2011, then since 2015, added helical, removed in-vivo,
removed nucleus... etc...)
https://scholar.google.com/scholar?q=cryo+em+DNA+nucleus+in-vivo+tomography&btnG=&hl=en&as_sdt=0%2C38&as_ylo=2011&as_vis=1



Analysis of chromatin fibers in Hela cells with electron tomography
http://link.springer.com/article/10.1007/s41048-015-0009-9/fulltext.html

Analysis of cryo-electron microscopy images does not support the
existence of 30-nm chromatin fibers in mitotic chromosomes in situ
http://www.pnas.org/content/105/50/19732.full
(that one is from 2008)

Chromatin structure: does the 30-nm fibre exist in vivo? Curr Opin Cell Biol
http://www.researchgate.net/profile/Kazuhiro_Maeshima/publication/42609370_Chromatin_structure_does_the_30-nm_fibre_exist_in_vivo/links/5437ccb50cf2d5fa292b695d.pdf

Chromatin as dynamic 10-nm fibers
http://www.researchgate.net/publication/261743937_Chromatin_as_dynamic_10-nm_fibers





--
-Nathan

[Nathan McCorkle]

I forgot to mention that we also think of these things from a
simulation standpoint... but computers still computer quite slowly
when you have so many molecules and so many interactions to account
for.

--
-Nathan