ily1 ily2 antibody ribosome system

[Greg Westin]

Hi, I am trying to postulate a way that a correct antibody is created.  My postulate is that, after an antibody is made by the ribosome, if it is working, it will bind something I call a ILY2 Protein which is bound to a 1lY1 protein bound to the ribosome. So, after the Ily2 protein reconfigures and the antibody binds, I think the that the ily1  protein is released.  It starts a chain reaction which goes causes another ribosome in the white blood cell to bind to a DNA that is the same. 

Ok, then, the ILY2 protein part of the icky complex and antibody meet a protein called ILY3  on the inside of the white blood cell membrane.  The ILY2 protein does. Then the antibody goes through the pore because of phosphorylation and initiates a B cell response.  The ILY2 Protein is a modified antigen.  

[John Ladasky]

On Friday, September 1, 2017 at 6:05:36 PM UTC-7, Greg Westin wrote:

Hi, I am trying to postulate a way that a correct antibody is created.  My postulate is that, after an antibody is made by the ribosome, if it is working, it will bind something I call a ILY2 Protein which is bound to a 1lY1 protein bound to the ribosome. So, after the Ily2 protein reconfigures and the antibody binds, I think the that the ily1  protein is released.  It starts a chain reaction which goes causes another ribosome in the white blood cell to bind to a DNA that is the same. 

Ok, then, the ILY2 protein part of the icky complex and antibody meet a protein called ILY3  on the inside of the white blood cell membrane.  The ILY2 protein does. Then the antibody goes through the pore because of phosphorylation and initiates a B cell response.  The ILY2 Protein is a modified antigen.  

Hi Greg,

Where do you get this hypothesis?  That's not how antibody molecules are created at all.

Any one B cell in the body makes one antibody protein.  There is a variable region in antibody molecules which differs between the individual B cells.  That variable region is highly diverse and pretty much random.  Antibodies have to be made well in advance of encountering the antigen, and the antigen cannot be known beforehand.  

Two implications follow from this process.  1) Many antibodies are made which are completely useless.  They will never encounter a matching antigen.  This is inefficient, but it's otherwise harmless.  2) Some antibodies are made which react with the proteins found in normal, healthy individuals.  These antibodies are potentially a problem: they can cause autoimmune disease.  In order to deal with this second problem, the body has a special organ where immature B cells are tested first to see if their antibodies react with healthy tissue.  This happens at the cell surface, not inside the cell at the ribosome.  In humans, the organ where this testing takes place is the spleen.  If an immature B cell is found to react with self, that cell is killed off instead of being allowed to mature, potentially divide, and spread throughout the body.