COVID-19 Antibody sequence / test

[AJP]

Does anyone know if there are sequences of any antibodies against SARS-CoV-2?

This question was prompted by this post in JOGL by Christopher LB Graham on 2020-03-05 at 2 am.  He asked about sequence(s) of antibodies with the idea of being able to express them.

I've never tried to express an antibody and can imagine it's potentially very hard to do for different reasons (plasmid size, post-translational modifications, etc).  But I'm interested to know if this information is available yet.

I've done some searching around but not come across anything yet.  It's hard to search for "SARS-CoV-2 antibody sequence" brings back loads of SARS papers.

Interesting paper on using SARS 2002 and MERS antibodies in Rosetta SnugDock computational binding models.

And another paper showing the SARS antibodies have good binding against the spike protein "SARS-CoV reagents can be utilized to characterize SARS-CoV-2 infection"

Some structures starting to appear but no antibodies yet: http://www.rcsb.org/pdb/results/results.do?tabtoshow=Current&qrid=A65AC30F

Cheers,

AJP

Related links:

Existing PCR based test thread.

Another collection of resources here: https://coronavirustechhandbook.com/

[Ayush Jain]

u can always look for SdAbs( single domain binding antibodies, there was a recent paper in journal cell about llama antibody which can be used to stop the virus proliferation by using these antibodies, also these are only variable regions of antibodies, so are around 15kDa in size or about 400bp.

hope this helps

Cheers mate

AJ