nquiry regarding esophageal cancer cohorts with histopathology data for TP53-WSI research
Adityaraj Dhuria
Dear cBioPortal Team,
I hope you are doing well.
My name is Aditya Raj, and I am a BTech student at Bennett University (The Times of India Group), India, working on a research project involving weakly supervised deep learning for predicting TP53 gene mutation status from H&E whole-slide images (WSIs) of esophageal carcinoma.
We are currently using TCGA-ESCA for model development and are seeking independent esophageal cancer cohorts for external validation. Given cBioPortal’s role in curating and providing access to well-annotated cancer genomics datasets across multiple institutions, I wanted to inquire whether any esophageal cancer studies available through cBioPortal have associated digital histopathology (whole-slide images) or identifiable institutional links through which pathology data access might be requested.
Specifically, we are interested in cohorts that include:
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TP53 mutation or sequencing data
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Clinical outcome information
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Potential availability of H&E whole-slide images through the originating institution
Any guidance on relevant studies, institutions to contact, or recommended next steps would be greatly appreciated.
Thank you for maintaining such a valuable resource for the cancer research community.
Kind regards,
Aditya Raj
BTech Student
Bennett University (The Times of India Group)
Greater Noida, India
Benjamin Gross
Thank you for your email. Unfortunately, we do not track which data modalities are available beyond what is shown in cBioPortal. You will need to follow the publication links associated with the cBioPortal studies to determine whether whole-slide images were published. Any clinical outcome information at the time the study was curated will be shown in the cBioPortal.
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