Unfortunately, the connection between VDDS and LDO1 is internal within the SiP and cannot be modified on the OSD335x and OSD335x-SM. However, we are in the process of characterizing the OSD335x C-SiP to see if it can support the power use case where VDDS is not connected to LDO1. We should have that characterization finalized in early January.
Additionally, the TL5209 is enabled with an internal pull up within the OSD335x family of devices. In the OSD335x and OSD335x-SM, this connection cannot be modified. However, in the OSD335x C-SiP, there is a pin, SYS_VDD1_CTL, that will allow a user to disable the TL5209."