The find pattern would be "<iframe.*?</iframe>" with "Grep" checked. You can use the Multi-File Search... dialog to run this against a folder containing your .txt files to see how many matches there are.
When I'm doing multi-file work like this I'll usually start out doing a Find All in the multi-file dialog and looking at all the results. If it looks like I want to do a replace all then I can go back into the dialog and do that. The replace pattern would be blank if you want to remove the iframe tags.
If I need to be more discerning I'll work through each file by file in the results using Find Next to make sure that I want to replace all the iframes. Or refine the find pattern to be more specific.
[fletcher]