subjects status of TBM Jacobian Maps (817) collection

[Ehsan Karimi]

​Hi

I have two major problems with using the ADNI database:

1. I want to extract the status of the collection subjects - TBM Jacobian Maps MDT-SC (817) - for the third year from the ADNIMERGE.csv file, but this information was not available for all subjects. While some articles were used from the status of these subjects after three years in their researches. Where can I find this subjects status after 3 years?​

​2. How can I find pre-processed original images of the subjects in this collection?

[Danielle J Harvey]

Hi there,

 

I’m not all that familiar with this collection, other than it appears to be the ADNI-1 screening scans. Not all individuals were followed for 3 years (some by design, since AD participants were only followed for 2 years in ADNI-1, and some because they dropped out/died/were lost to follow-up), so you won’t be able to get the diagnosis for all of these individuals after 3 years. ADNIMERGE should have all of the available follow-up information for these individuals, so that’s probably the easiest place to find the diagnosis after 3 years (or last diagnosis).

 

There is a collection for the ADNI-1 screening 1.5T scans (there are more than 817 scans here because there are 2 different scaled versions of the scans for some people and both are included in the collection…there are actually scans for 818 people in this collection, I believe). You can refer to the following paper for some information about this collection:

 

Wyman BT, Harvey DJ, Crawford K, Bernstein MA, Carmichael O, Cole PE, Crane PK, DeCarli C, Fox NC, Gunter JL, Hill D, Killiany RJ, Pachai C, Schwarz AJ, Schuff N, Senjem ML, Suhy J, Thompson PM, Weiner M, Jack CR Jr.  Standardization of analysis sets for reporting results from ADNI MRI data.  Alzheimers and Dementia (2013);9:332-337. PMCID: PMC3891834

 

Danielle

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[Ehsan Karimi]

Thanks Danielle J Harvey...

Is it possible that a patient's state changes from AD to Normal? It can be seen in two cases but I have read before that it's not possible...! I want to know if it's a mistake in state validation or it could happen.

---
best regards

Ehsan Karimi

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[Danielle J Harvey]

Hi Ehsan,

 

A change from AD to normal seems very unlikely. Do you have the specific RID (or PTID) for those cases, so I can look into it a little more?

 

Thanks,

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[Michael Romano]

Hi all,

We actually have quite a few of these. We call them "reversion" cases. I have a list of RIDs here. I can generate a list in a second. May I attach a list to this email chain?

[Danielle J Harvey]

Hi Mike,

 

Some reversions are definitely possible, though I’d be surprised by an AD to NL reversion (AD to MCI or MCI to NL might be more expected). We’d prefer data not be attached to emails through this Google Group, but you can include a few RIDs in the text of the email. Alternatively, you may email me directly with your list (djha...@ucdavis.edu), so that I can look into it more closely (that might not happen until later today as I’m in meetings all day!)

 

Danielle

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[Ehsan Karimi]

Sorry, I mean change from AD to MCI mode. for example subject 128_S_0167 only had AD state in baseline and in all the next visits, his state is MCI:

167	128_S_0167	bl	128	ADNI1	ADNI1	3/16/2006	AD	Dementia	0	0	0	0
167	128_S_0167	m06	128	ADNI1	ADNI1	9/11/2006	AD	MCI	0.490075	5.86885	6	6
167	128_S_0167	m12	128	ADNI1	ADNI1	5/16/2007	AD	MCI	1.16632	13.9672	12	12
167	128_S_0167	m18	128	ADNI1	ADNI1	10/23/2007	AD		1.60438	19.2131	18	18
167	128_S_0167	m24	128	ADNI1	ADNI1	2/13/2009	AD	MCI	2.91581	34.918	36	24

and the same condition for   033_S_0739:

033_S_0739

bl

33

ADNI1

ADNI1

7/31/2006

AD

MCI

0

0

0

0

58:32.0

033_S_0739

m06

33

ADNI1

ADNI1

2/12/2007

AD

MCI

0.536619

6.42623

6

6

58:32.0

033_S_0739

m12

33

ADNI1

ADNI1

8/6/2007

AD

MCI

1.01574

12.1639

12

12

58:32.0

033_S_0739

m18

33

ADNI1

ADNI1

2/18/2008

AD

1.55236

18.5902

18

18

58:32.0

033_S_0739

m24

33

ADNI1

ADNI1

8/25/2008

AD

MCI

2.06982

24.7869

24

24

58:32.0

---
best regards

Ehsan Karimi

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[Danielle J Harvey]

Hi Ehsan,

 

I had a chance to take a look at this in between meetings. RID 167 (128_S_0167) is a reversion from Dementia to MCI.

 

RID 739 (033_S_0739) was considered AD at the screening visit (which in ADNI-1 was the diagnosis that determined the visitation schedule), but during the baseline visit, a more complete evaluation was done and the individual was deemed to be MCI. In general, the Clinical Core has recommended the use of the diagnosis at the baseline visit as a more accurate diagnosis, since it is based on more information than was collected at the screen visit. So, this person, I would consider to be MCI at all visits.

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[Ehsan Karimi]

thanks all... 

😊

---
best regards

Ehsan Karimi

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