I had issues with disk based sessions on apache - turns out it was in part because of the threading.
I solved the session issue a different way, but these settings did help, and may guide you into getting apache into single thread mode.
(It was the "processes=1" setting that helped me. Maybe this will help you too?)
<VirtualHost *:80>
WSGIScriptAlias / /opt/myapp/web/main.py/
WSGIDaemonProcess main processes=1 threads=25
WSGIProcessGroup main
Alias /static /opt/myapp/web/static/
<Directory /opt/myapp/web/>
Order allow,deny
Allow from all
</Directory>
</VirtualHost>
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