There is a consensus here that the project really needs more centralized documentation, especially howto's for newbies.
In the meantime I highly recommend for "mere-mortal end users" that you spend your first months or two getting to know TW in its traditional all-in-one-HTML form, starting out with the core and later on trying out the most popular plugins. For minimum headaches, I recommend the last version of FF 3.6, available as a portable app if you need to also have a newer version installed.
From there, if server-side storage is critical for you, pick one and work with it for a while. Or, continue your theming/plugin education by reverse-engineering some of the "packaged distros" (core+theme+plugins).
The list here is very helpful, but of course only if you have specific questions and in the case of problems,
provide the needed specific information on your setup.
If you'd rather use something with a flatter learning curve, let us know what you're trying to accomplish and I'm sure you'll get some good recommendations.