Hi Peter,
Thanks for pointing me to your interesting post. I'll test path headers for our Polycom phones in our test environent.
After your suggestion about X-lite, I've tested Jitsi using IP address instead of the domain name for registering, and everything worked. Anyway, I became curious about why INVITEs were not leaving proxy when domain name was used. Checking proxy configuration, I've found what I was missing: parameter 'Allow Non-Local Domain Relay' was unchecked. If the parameter is checked, Jitsi works as expected.
So, it seems that that that parameter affects behaviour of SIP messages forwarded between proxies in the same cluster, but in different regions. I thought that that parameter was intended to be used to block relaying for different domains, so I unchecked it.
Massimo